Results 211 to 220 of about 113,580 (306)

Novel Therapeutics for Familial Chylomicronemia Syndrome. [PDF]

Curr Atheroscler Rep
Izar MC, Fonseca FAH.
europepmc   +1 more source

MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
MiR‐100‐5p overexpression downregulates PRMT5, leading to increased PTEN activity and reduced AKT signaling. This molecular cascade promotes cardiomyocyte apoptosis, enhances fibrotic remodeling, and exacerbates cardiac dysfunction following myocardial ischemia–reperfusion injury.
Zhenya Wang, Tong‐You Wade Wei, Jo‐Mei Maureen Chen, Ke Zhang, Yiwei Zhang, Huiting Shi, Hsiang‐Chun Su, I‐Shan Hsieh, Chang‐Tze Ricky Yu, Guo‐Jun Zhao   +9 more
wiley   +1 more source

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome. [PDF]

Alzheimers Dement
Chen XQ, Zuo X, Becker A, Mante M, Florio JB, Jadhav SG, Albay R, Johnstone A, Karachentsev D, Rissman R, Zhao H, Dowdy SF, Mobley WC.   +12 more
europepmc   +1 more source

APP antisense oligonucleotides are effective in rescuing mitochondrial phenotypes in human iPSC-derived trisomy 21 astrocytes. [PDF]

Alzheimers Dement
Thirumalai S, Livesey FJ, Patani R, Hung C.   +3 more
europepmc   +1 more source

Sequence-Specific Free Energy Changes in DNA/RNA Induced by a Single LNA-T Modification in Antisense Oligonucleotides. [PDF]

Int J Mol Sci
Tomita-Sudo E, Akita T, Sakimoto N, Tahara-Takamine S, Kawakami J.   +4 more
europepmc   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinhui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

G-Quadruplex-Based Splice Switching as a Therapeutic Approach in Duchenne Muscular Dystrophy. [PDF]

ACS Chem Biol
Iwase R, Ishiguro T, Hara RI, Nagata T, Yokota T.   +4 more
europepmc   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, Volume 12, Issue 21, June 5, 2025.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou   +11 more
wiley   +1 more source