Results 221 to 230 of about 113,580 (306)

Activation of Smooth Muscle K_ir2.1 Channels and Na⁺/K⁺-ATPase Mediates Dilation of Porcine Coronary Arterioles at Physiological Levels of Potassium. [PDF]

Int J Mol Sci
Hein TW, Razavi HM, Xu X, Somvanshi S, Muthuchamy M, Kuo L.   +5 more
europepmc   +1 more source

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

Clinically relevant pseudoexons of the GALNS gene and their antisense-based correction. [PDF]

Mol Med
Bychkov I, Shchukina E, Zakharova E.
europepmc   +1 more source

The 'genetic zipper' method offers a cost-effective solution for aphid control. [PDF]

Front Insect Sci
Oberemok VV, Puzanova YV, Gal'chinsky NV.   +2 more
europepmc   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

The history of Down syndrome–associated Alzheimer's disease; past, present, and future

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract The landscape of Down syndrome–associated Alzheimer's disease (DSAD) research reflects decades of scientific endeavor and collaborative effort, charting a remarkable journey from initial observations to the elucidation of complex genetic and molecular mechanisms.
Lucia Maure‐Blesa, María Carmona‐Iragui, Ira Lott, Elizabeth Head, Thomas Wisniewski, Michael S. Rafii, Joaquín Espinosa, Jesús Flórez, William C. Mobley, Anthony Holland, André Strydom, Shahid Zaman, Juan Fortea   +12 more
wiley   +1 more source

A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells. [PDF]

PLoS One
Canalis E, Yu J, Schilling L, Jafar-Nejad P, Carrer M.   +4 more
europepmc   +1 more source

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models [PDF]

, 2018
et al,, Hoye, Mariah L, Miller, Timothy M, Schoch, Kathleen M, Setnicka, Amy, Shabsovich, Mark, Wegener, Amy J   +6 more
core   +1 more source

Brain Metabolic Features of FUS‐ALS: A 2‐[18F]FDG‐PET Study

Annals of Neurology, Volume 97, Issue 6, Page 1134-1143, June 2025.
Objective We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). Methods We employed the 2‐sample t‐test model of SPM12, implemented in MATLAB, to compare 12 FUS‐ALS ...
Antonio Canosa, Umberto Manera, Rosario Vasta, Grazia Zocco, Francesca Di Pede, Sara Cabras, Filippo De Mattei, Francesca Palumbo, Barbara Iazzolino, Emilio Minerva, Luca Sbaiz, Maura Brunetti, Salvatore Gallone, Maurizio Grassano, Enrico Matteoni, Giulia Polverari, Giuseppe Fuda, Federico Casale, Paolina Salamone, Giovanni De Marco, Giulia Marchese, Cristina Moglia, Andrea Calvo, Marco Pagani, Adriano Chiò   +24 more
wiley   +1 more source

PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background As an essential transcription factor, Myc‐associated zinc‐finger protein (MAZ) is frequently upregulated in many human tumors and is a well‐documented oncogene. However, we found high expression of MAZ was closely associated with good survival outcomes in patients with stomach adenocarcinoma (STAD), and the underlying mechanism ...
Dong Xing, Ting Zhao, Chenchen Mao, Zheng Han, Wanxia Cai, Teming Zhang, Dianfeng Mei, Wangkai Xie, Jiaye Yu, Zhonghan Wu, Zhiyuan Chen, Shiyu Feng, Xian Shen, Xiangyang Xue, Dan Xiang   +14 more
wiley   +1 more source