Results 31 to 40 of about 218,639 (188)
Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD
The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič+4 more
doaj +1 more source
Antisense oligonucleotides complementary to RNA targets promise generality and ease of drug design. The first systemically administered antisense drug was recently approved for treatment and others are in clinical development. Chemical modifications that
Lykke Pedersen+3 more
doaj +1 more source
Liver and kidney uptake and antisense activity is studied for a series of Locked Nucleic Acid (LNA) oligonucleotides with fully stereo-defined, internucleoside linkages.
Henrik Frydenlund Hansen+5 more
doaj +1 more source
Antisense Oligonucleotides: Concepts and Pharmaceutical Applications
Antisense oligonucleotides are drugs whose mechanism is based on binding to RNA target sequences. For this purpose, they modify the protein expression through steric hindrance and exon omission.
Ariana Araya+5 more
doaj +1 more source
Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models
Mutations in superoxide dismutase 1 (SOD1) are responsible for 20% of familial ALS. Given the gain of toxic function in this dominantly inherited disease, lowering SOD1 mRNA and protein is predicted to provide therapeutic benefit.
A. McCampbell+22 more
semanticscholar +1 more source
Silencing Antibiotic Resistance with Antisense Oligonucleotides
Antisense technologies consist of the utilization of oligonucleotides or oligonucleotide analogs to interfere with undesirable biological processes, commonly through inhibition of expression of selected genes.
Saumya Jani+2 more
doaj +1 more source
Targeted delivery of antisense oligonucleotides to pancreatic β-cells
Receptor-dependent productive uptake of GLP1-conjugated antisense oligonucleotides occurs selectively in pancreatic β-cells. Antisense oligonucleotide (ASO) silencing of the expression of disease-associated genes is an attractive novel therapeutic ...
Carina Ämmälä+19 more
semanticscholar +1 more source
Transport Oligonucleotides—A Novel System for Intracellular Delivery of Antisense Therapeutics
Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept study, we propose a novel delivery system for asONs which implies the ...
Oleg V. Markov+9 more
doaj +1 more source
Background A primary concern when targeting HIV-1 RNA by means of antisense related technologies is the accessibility of the targets. Using a library selection approach to define the most accessible sites for 20-mer oligonucleotides annealing within the ...
Berkhout Ben+4 more
doaj +1 more source
Oligonucleotide therapeutics have emerged as a third distinct platform for drug discovery within the pharmaceutical industry. Five oligonucleotide-based drugs have been approved by the US FDA and over 100 oligonucleotides drugs are currently at different
Colton M. Miller+6 more
semanticscholar +1 more source