Results 41 to 50 of about 265,106 (349)

Taking control of gene expression with light-activated oligonucleotides

BioTechniques, 2007
The recent development of caged oligonucleotides that are efficiently activated by ultraviolet (UV) light creates opportunities for regulating gene expression with very high spatial and temporal resolution.
Ivan J. Dmochowski, XinJing Tang
doaj   +1 more source

Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides

Genetics in Medicine, 2019
Using exome sequencing, the underlying variants in many persons with autosomal recessive diseases remain undetected. We explored autosomal recessive Stargardt disease (STGD1) as a model to identify the missing heritability.
R. Sangermano, A. Garanto, Mubeen Khan, E. H. Runhart, M. Bauwens, Nathalie M. Bax, L. I. Born, M. I. Khan, S. S. Cornelis, J. Verheij, J. W. Pott, A. Thiadens, C. Klaver, B. Puech, I. Meunier, Sarah Naessens, G. Arno, A. Fakin, K. Carss, F. Raymond, A. Webster, C. Dhaenens, H. Stöhr, F. Grassmann, B. H. Weber, C. Hoyng, E. Baere, Silvia Albert, R. Collin, F. Cremers   +29 more
semanticscholar   +1 more source

Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes [PDF]

, 1994
Encapsulation of oligonucleotides in antibody-targeted liposomes (immunoliposomes) which bind to target cells permits intracellular delivery of the oligonucleotides.
Akhtar, Akhtar, Barré-Sinoussi, Boutorine, Boutorine, Boutorine, Boutorine, de Smidt, Feener, Gamper, Goodchild, Hope, Kabanov, Kim, Kinchington, Krieg, Lemke, Leonetti, Leserman, Leserman, Letsinger, Loke, Machy, Machy, Machy, Matsukura, Matthay, Oberhauser, Rebaï, Rey, Saison-Behmoaras, Senior, Shaw, Shea, Stein, Stewart, Suzuki, Svinarchuk, Thierry, Uhlmann, Yakubov, Zamecnik, Zelphati   +42 more
core   +1 more source

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

Nucleic Acids Research, 2017
RNA plays a central role in the expression of all genes. Because any sequence within RNA can be recognized by complementary base pairing, synthetic oligonucleotides and oligonucleotide mimics offer a general strategy for controlling processes that affect
Xiulong Shen, D. Corey
semanticscholar   +1 more source

Antisense oligonucleotides extend survival of prion-infected mice

JCI Insight, 2019
Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals caused by conversion of cellular prion protein (PrPC) into a self-propagating neurotoxic conformer (prions; PrPSc).
G. J. Raymond, H. Zhao, B. Race, L. Raymond, K. Williams, E. Swayze, Samantha Graffam, Jason Le, T. Caron, J. Stathopoulos, R. O’Keefe, L. Lubke, A. Reidenbach, Allison Kraus, S. Schreiber, C. Mazur, D. Cabin, J. Carroll, E. Minikel, H. Kordasiewicz, B. Caughey, S. M. Vallabh   +21 more
semanticscholar   +1 more source

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Forty years of research have shown that antisense oligonucleotides have great potential to target mRNAs of disease-associated genes and noncoding RNAs.
S. Miroshnichenko, O. Patutina, E. Burakova, B. Chelobanov, A. Fokina, V. Vlassov, S. Altman, M. Zenkova, D. Stetsenko   +8 more
semanticscholar   +1 more source

Locked nucleic acid: tighter is different [PDF]

, 2013
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity ...
Watts, Jonathan
core   +1 more source

Improved Lower Bounds for Constant GC-Content DNA Codes [PDF]

IEEE Transactions on Information Theory, vol. 54, no. 1, pp. 391-394, 2008, 2008
The design of large libraries of oligonucleotides having constant GC-content and satisfying Hamming distance constraints between oligonucleotides and their Watson-Crick complements is important in reducing hybridization errors in DNA computing, DNA microarray technologies, and molecular bar coding.
arxiv   +1 more source

Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD

Molecules, 2020
The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič, Matja Zalar, Boris Rogelj, Janez Plavec, Primož Šket   +4 more
doaj   +1 more source

Regulation of metabolism by miR-378 [PDF]

, 2014
The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core   +1 more source