Results 11 to 20 of about 414,656 (346)
The delivery of therapeutic oligonucleotides [PDF]
Nucleic Acids Research, 2016 The oligonucleotide therapeutics field has seen remarkable progress over the last few years with the approval of the first antisense drug and with promising developments in late stage clinical trials using siRNA or splice switching oligonucleotides ...
R. Juliano
semanticscholar +4 more sources
Antisense oligonucleotides [PDF]
Neurology Genetics, 2019 There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in ...
Daniel R. Scoles, E. Minikel, S. Pulst
semanticscholar +4 more sources
Making Oligonucleotide Conjugates and Breaking Oligonucleotides [PDF]
Nucleic Acids Symposium Series, 2007 Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups.
Esther Yeheskiely +4 more
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Journal of the American Chemical Society, 2014 Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N ...
James, Carrie R. +6 more
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RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
Cells, 2020 The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to
Sarah Bajan, G. Hutvagner
semanticscholar +1 more source
Plant Methods, 2017 Background The complex cell wall structure of algae often precludes efficient extraction of their genetic material. The purpose of this study was to design a next-generation sequencing-suitable DNA isolation method for unicellular, achlorophyllous, yeast-
Tomasz Jagielski +5 more
doaj +1 more source
Chemical synthesis of oligonucleotides using acetone as a washing solvent
BioTechniques, 2009 Acetone is being proposed as the main washing solvent during automated synthesis of oligonucleotides to reduce acetonitrile usage in the assembly process and endure the impact of global acetonitrile shortage.
Paul Gaytán
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Therapeutic Antisense Oligonucleotides Are Coming of Age.
Annual Review of Medicine, 2019 The first published description of therapeutic applications of antisense oligonucleotide (ASO) technology occurred in the late 1970s and was followed by the founding of commercial companies focused on developing antisense therapeutics in the late 1980s ...
C. Bennett
semanticscholar +1 more source
Acta Agriculturae Slovenica, 2008 One of the basic principles of molecular biology is the use oligonucleotides with comparable melting temperatures (Tm). To accommodate various evolutionary changes in target gene sequences in order to detect numerous variants of the same gene in complex ...
Blaž STRES, Boštjan MUROVEC
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Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
Nucleic Acids Research, 2017 RNA plays a central role in the expression of all genes. Because any sequence within RNA can be recognized by complementary base pairing, synthetic oligonucleotides and oligonucleotide mimics offer a general strategy for controlling processes that affect
Xiulong Shen, D. Corey
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