Results 11 to 20 of about 446,863 (330)

Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection

Frontiers in Immunology, 2020
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children. Currently, there is no RSV vaccine or universally accessible antiviral treatment available. Addressing the urgent need for new antiviral
Sandra Axberg Pålsson, Aleksandra Dondalska, Joseph Bergenstråhle, Caroline Rolfes, Albin Björk, Laura Sedano, Ultan F. Power, Marie-Anne Rameix-Welti, Joakim Lundeberg, Marie Wahren-Herlenius, Peter Mastrangelo, Jean-Francois Eleouet, Ronan Le Goffic, Marie Galloux, Anna-Lena Spetz   +14 more
doaj   +1 more source

Nanoparticles-Based Oligonucleotides Delivery in Cancer: Role of Zebrafish as Animal Model

Pharmaceutics, 2021
Oligonucleotide (ON) therapeutics are molecular target agents composed of chemically synthesized DNA or RNA molecules capable of inhibiting gene expression or protein function.
Sara Bozzer, Michele Dal Bo, Giuseppe Toffoli, Paolo Macor, Sara Capolla   +4 more
doaj   +1 more source

Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes [PDF]

, 1994
Encapsulation of oligonucleotides in antibody-targeted liposomes (immunoliposomes) which bind to target cells permits intracellular delivery of the oligonucleotides.
Akhtar, Akhtar, Barré-Sinoussi, Boutorine, Boutorine, Boutorine, Boutorine, de Smidt, Feener, Gamper, Goodchild, Hope, Kabanov, Kim, Kinchington, Krieg, Lemke, Leonetti, Leserman, Leserman, Letsinger, Loke, Machy, Machy, Machy, Matsukura, Matthay, Oberhauser, Rebaï, Rey, Saison-Behmoaras, Senior, Shaw, Shea, Stein, Stewart, Suzuki, Svinarchuk, Thierry, Uhlmann, Yakubov, Zamecnik, Zelphati   +42 more
core   +1 more source

Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry

Molecules, 2012
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several ...
Wei Gong, Tim Efthymiou, Jean-Paul Desaulniers   +2 more
doaj   +1 more source

Control of Energy Transfer Between Pyrene‐ and Perylene‐Nucleosides by the Sequence of DNA‐Templated Supramolecular Assemblies

ChemistryOpen, 2020
DNA was used as supramolecular scaffold to order chromophores and control their optical properties. Ethynylpyrene as energy donor was attached to 2′‐desoxy‐2‐aminoadenosine that binds selectively to thymidines (T) in the template.
Sara Müller, Dr. Yannic Fritz, Prof. Hans‐Achim Wagenknecht   +2 more
doaj   +1 more source

New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins [PDF]

Diabetes & Metabolism Journal, 2022
Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, even under optimal statin therapy, a significant residual ASCVD risk remains.
Kyuho Kim, Henry N. Ginsberg, Sung Hee Choi   +2 more
doaj   +1 more source

Pharmacological Activity and Clinical Use of PDRN

Frontiers in Pharmacology, 2017
PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers.
Francesco Squadrito, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Letteria Minutoli, Domenica Altavilla   +6 more
doaj   +1 more source

Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]

, 2011
In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas, Heil, Korbinian, Pearson, David   +2 more
core   +1 more source

Simultaneous Colorimetric Detection of a Variety of Salmonella spp. in Food and Environmental Samples by Optical Biosensing Using Oligonucleotide-Gold Nanoparticles

Frontiers in Microbiology, 2019
Optical biosensors for rapid detection of significant foodborne pathogens are steadily gaining popularity due to its simplicity and sensitivity. While nanomaterials such as gold nanoparticles (AuNPs) are commonly used as signal amplifiers for optical ...
Irwin A. Quintela, Irwin A. Quintela, Benildo G. de los Reyes, Chih-Sheng Lin, Vivian C. H. Wu, Vivian C. H. Wu   +5 more
doaj   +1 more source

Direct oligonucleotide sequencing with nanopores [PDF]

Open Research Europe, 2020
Third-generation DNA sequencing has enabled sequencing of long, unamplified DNA fragments with minimal steps. Direct sequencing of ssDNA or RNA gives valuable insights like base-level modifications, phosphoramidite synthesis yield estimates and strand quality analysis, without the need to add the complimentary strand.
Chalapati, Sachin, Crosbie, Conor A, Limbachiya, Dixita, Pinnamaneni, Nimesh   +3 more
openaire   +5 more sources