Results 21 to 30 of about 414,656 (346)

Emerging microRNA Therapeutic Approaches for Cystic Fibrosis

Frontiers in Pharmacology, 2018
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs.
Pauline Bardin, Florence Sonneville, Harriet Corvol, Harriet Corvol, Olivier Tabary   +4 more
doaj   +1 more source

Unwinding the SARS-CoV-2 Ribosomal Frameshifting Pseudoknot with LNA and G-Clamp-Modified Phosphorothioate Oligonucleotides Inhibits Viral Replication

Biomolecules, 2023
Ribosomal frameshifting (RFS) at the slippery site of SARS-CoV-2 RNA is essential for the biosynthesis of the viral replication machinery. It requires the formation of a pseudoknot (PK) structure near the slippery site and can be inhibited by PK ...
Ekaterina Knizhnik, Stepan Chumakov, Julia Svetlova, Iulia Pavlova, Yuri Khodarovich, Vladimir Brylev, Vjacheslav Severov, Rugiya Alieva, Liubov Kozlovskaya, Dmitry Andreev, Andrey Aralov, Anna Varizhuk   +11 more
doaj   +1 more source

Lipoplexes to Deliver Oligonucleotides in Gram-Positive and Gram-Negative Bacteria: Towards Treatment of Blood Infections

Pharmaceutics, 2021
Bacterial resistance to antibiotics threatens the ability to treat life-threatening bloodstream infections. Oligonucleotides (ONs) composed of nucleic acid mimics (NAMs) able to inhibit essential genes can become an alternative to traditional antibiotics,
Sara Pereira, Rita Sobral Santos, Luís Moreira, Nuno Guimarães, Mariana Gomes, Heyang Zhang, Katrien Remaut, Kevin Braeckmans, Stefaan De Smedt, Nuno Filipe Azevedo   +9 more
doaj   +1 more source

Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

Molecules, 2020
In the last three decades, oligonucleotides have been extensively investigated as probes, molecular ligands and even catalysts within therapeutic and diagnostic applications.
Steven Ochoa, V. Milam
semanticscholar   +1 more source

Pharmacological Activity and Clinical Use of PDRN

Frontiers in Pharmacology, 2017
PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers.
Francesco Squadrito, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Letteria Minutoli, Domenica Altavilla   +6 more
doaj   +1 more source

Oligonucleotides-Based Therapeutics [PDF]

Biomedicines, 2021
This Special Issue of Biomedicines aims to outline nucleic-acid-based strategies that have emerged as tools to regulate specific gene expression and, more recently, as a new class of medicines [...]
openaire   +3 more sources

Simultaneous Colorimetric Detection of a Variety of Salmonella spp. in Food and Environmental Samples by Optical Biosensing Using Oligonucleotide-Gold Nanoparticles

Frontiers in Microbiology, 2019
Optical biosensors for rapid detection of significant foodborne pathogens are steadily gaining popularity due to its simplicity and sensitivity. While nanomaterials such as gold nanoparticles (AuNPs) are commonly used as signal amplifiers for optical ...
Irwin A. Quintela, Irwin A. Quintela, Benildo G. de los Reyes, Chih-Sheng Lin, Vivian C. H. Wu, Vivian C. H. Wu   +5 more
doaj   +1 more source

Oligonucleotides

, 2013
Oligonucleotides are (short) chains of (chemically modified) ribo- or deoxyribonucleotides. Their ability to bind to chromosomal DNA, mRNA, or non-coding RNA (ncRNA) through Watson-Crick and Hoogsteen base pairing offers possibilities for highly specific intervention in gene transcription, mRNA translation, gene repair, and recombination for ...
Schiffelers, R.M., Mastrobattista, E.
openaire   +4 more sources

Antisense oligonucleotides for neurodegeneration [PDF]

Science, 2020
Promising clinical results for Huntington's disease give hope for other ...
Leavitt, BR, Tabrizi, SJ
openaire   +4 more sources

The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides

Pharmaceuticals, 2022
Nucleic acids play a central role in human biology, making them suitable and attractive tools for therapeutic applications. While conventional drugs generally target proteins and induce transient therapeutic effects, nucleic acid medicines can achieve ...
Miklós Bege, Anikó Borbás
doaj   +1 more source