Results 121 to 130 of about 37,441 (229)

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 332-342, February 2026.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Biological Templates for Gold Nanocluster Assembly: Design and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The review discusses the fundamental properties of ultrasmall gold nanoclusters and their surface modification strategies for targeted biomedical use. It examines biologically guided assembly processes and their effects on optical behavior, particularly aggregation‐induced emission.
Zeineb Ayed, Abdallah Alhalabi, Didier Gasparutto, Xavier Le Guével   +3 more
wiley   +1 more source

Binding of Ions to Oligopeptides

Biophysical Journal, 1973
A model for the binding of ions to oligopeptides, in which nearest neighbor interactions are considered is developed. Equations for the titration curves are derived The apparent association constants are determined as a function of the degree of polymerization and of the interactions between nearest neighbors.
openaire   +2 more sources

Guanidinium Like‐Charge Ion Pairing and Oligoarginine Aggregation in Water by Nuclear Magnetic Resonance, Cryo‐Electron Microscopy, and Molecular Dynamics

Aggregate, Volume 7, Issue 2, February 2026.
This study shows that guanidinium cations weakly attract one another in water and form like‐charge contact ion pairs. From NMR, we determine the free energy of ion‐pair formation to be ≈${\approx }$ –0.5 kJ mol−1${\rm mol}^{-1}$, consistent with all‐atom MD simulations and DFT calculations.
Denys Biriukov, Zuzana Osifová, Man Thi Hong Nguyen, Philip E. Mason, Martin Dračínský, Pavel Jungwirth, Jan Heyda, Mattia I. Morandi, Mario Vazdar   +8 more
wiley   +1 more source

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 310-323, February 2026.
ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella, Sudeep Sarma, Caroline M. Hinesley, Corey E. Febo, Keith A. Breau, Deniz Durmusoglu, Ethan Purnell, Scott T. Magness, Carol K. Hall, Stefano Menegatti, Nathan Crook   +10 more
wiley   +1 more source

Growth Hormone–Releasing Peptides: Investigation of Their Secondary Structure, Thermal Stability, and Model Membrane Interactions

Chirality, Volume 38, Issue 2, February 2026.
Eight growth hormone–releasing peptides were analyzed by electronic circular dichroism spectroscopy, including evaluation of their thermal stability and interactions with model membranes. In the selected case, occurring interactions were successfully described by the density functional theory calculations, revealing how model membranes affected ...
František Králík, Anna Kvíčalová, Adriana Salaďáková, Martin Kuchař, Vladimír Setnička   +4 more
wiley   +1 more source

SYNTHESIS OF OLIGOPEPTIDES OF DEFINED FRAGMENT COMPOSITION [PDF]

, 2011
The advantages of the solid-phase peptide synthesis were used. The peptide chain was built on specially processed insoluble polymer resin: Wang- and Rink Amide MBHA-resin.
Rumyana Cherkezova, Tamara Paypanova, Tatyana Hristova   +2 more
core  

Transient Cyclic Structured Oligonucleotide Designs for Therapeutic Applications

Current Protocols, Volume 6, Issue 2, February 2026.
Abstract Oligonucleotide‐based therapeutics are now widely used in clinical settings. From the late 1980s to the mid‐1990s, efforts to improve therapeutic efficacy focused on imparting drug‐like properties to oligonucleotides, emphasizing nuclease stability and target sequence affinity.
Sudhir Agrawal
wiley   +1 more source

Potentials of cellulosic wastes in media formulation [PDF]

, 2007
Potential use of cellulosic wastes as carbon and energy sources in selective media formulations was investigated. Two agar media, Czapek-Dox and Sabouraud’s agar, were modified by substituting their carbon sources with cellulose, sawdust and sugarcane ...
Adeniji, B. R., Chidozie, F., Chinedu, S. N., Okochi, V. I., Olukoju, D., Omidiji, O., Omowaye, O. O.   +6 more
core   +1 more source