Results 61 to 70 of about 7,958 (215)

Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia

Human Mutation, 2017
Microdeletions of the Y chromosome (YCMs), Klinefelter syndrome (47,XXY), and CFTR mutations are known genetic causes of severe male infertility, but the majority of cases remain idiopathic.
M. Oud, L. Ramos, M. O’Bryan, R. McLachlan, Ö. Okutman, S. Viville, P. D. de Vries, D. Smeets, D. Lugtenberg, J. Hehir-Kwa, C. Gilissen, M. van de Vorst, L. Vissers, A. Hoischen, A. Meijerink, K. Fleischer, J. Veltman, M. J. Noordam   +17 more
semanticscholar   +1 more source

Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel

Frontiers in Endocrinology, 2021
BackgroundInfertility affects about 7% of the general male population. The underlying cause of male infertility is undefined in about 50% of cases (idiopathic infertility).
Vincenza Precone, Rossella Cannarella, Stefano Paolacci, Gian Maria Busetto, Tommaso Beccari, Liborio Stuppia, Gerolamo Tonini, Alessandra Zulian, Giuseppe Marceddu, Aldo E. Calogero, Matteo Bertelli, Matteo Bertelli, Matteo Bertelli   +12 more
doaj   +1 more source

Obesity Is an Independent Risk Factor for Oligozoospermia, With Co‐Existing Hyperglycemia Exacerbating Risks of Asthenozoospermia and Elevated Sperm DNA Fragmentation

Andrology, EarlyView.
ABSTRACT Background Metabolic health plays a critical role in maintaining male fertility and may influence offspring health. Therefore, it is necessary to incorporate metabolic indicators into the clinical assessment of male fertility. However, the relationships between different metabolic abnormalities and semen quality remain incompletely understood.
Rubing Hu, Haijiao Zou, Qiaodan Li, Weihong Fan, Jian Xu   +4 more
wiley   +1 more source

Chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar and their association with sperm retrieval intracytoplasmic sperm injection outcomes

Arab Journal of Urology, 2017
Objective: To study the types and incidence of chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar, and to compare the hormonal changes, testicular sperm retrieval rate, and intracytoplasmic sperm injection ...
Mohamed Arafa, A. Majzoub, S. Alsaid, W. El Ansari, A. Al Ansari, Yara El-bardisi, H. Elbardisi   +6 more
semanticscholar   +1 more source

Sperm Selection Using Micro Swim‐Up: Improvement of Chromatin Integrity Compared to Density Gradient Centrifugation

Andrology, EarlyView.
ABSTRACT Background Selecting high‐quality spermatozoa with optimal nuclear integrity is a crucial step in assisted reproductive technologies (ART). While density gradient centrifugation (DGC) is widely used, the associated centrifugation steps may induce cell stress, potentially damaging sperm DNA.
Simone Palini, Serena Benedetti, Silvia De Stefani, Luca Galluzzi, Mariangela Primiterra, Sara Rita D'Errico, Michele Tanturli, Monica Muratori   +7 more
wiley   +1 more source

Integrated Analysis of DNA Methylation and mRNA Expression Profiles to Identify Key Genes in Severe Oligozoospermia

Frontiers in Physiology, 2017
Severe oligozoospermia (SO) is a complex disorder, whose etiology is the combined effect of genetic factors and epigenetic conditions. In this study, we examined DNA methylation and mRNA expression status in a set of testicular tissues of SO patients (n =
Zhiming Li, Zhuang Xuan, Jin-Long Zeng, C. Tzeng   +3 more
semanticscholar   +1 more source

Comparison of Intracytoplasmic Sperm Injection Outcomes between Oligozoospermic, Obstructive Azoospermic and Non-Obstructive Azoospermic Patients [PDF]

International Journal of Fertility and Sterility, 2012
Background To determine the differences in sperm quality and results of intracytoplasmic sperm injection (ICSI) cycles between three groups of male factor infertile couples: oligozoospermic, obstructive azoospermic and non-obstructive azoospermic ...
Ensieh Shahrokh Tehraninejad Tehraninejad, Elham Pourmatroud, Mohammad Ali Sadighi Gilani, Mahdi Rakebi, Zahra Azimi Neko, Arezoo Arabipoor   +5 more
doaj  

Live Birth Rates After Varicocele Embolization in Patients After Failed In Vitro Fertilization With Intracytoplasmic Sperm Injection

Andrology, EarlyView.
ABSTRACT Background and Objectives While in vitro fertilization with intracytoplasmic sperm injection (IVF‐ICSI) bypasses abnormalities in sperm concentration, motility, and morphology, it still has a significant failure rate. We report our experience on the effect of varicocele embolization (VE) on couples with varicocele related primary male factor ...
Anthony Verstandig, Adam Farkas
wiley   +1 more source

Children Born Using Ejaculated Sperm From Men With Klinefelter Syndrome. Is Sperm Production Associated With Testicular Volume?

Andrology, EarlyView.
ABSTRACT Background A large number of children have been born using testicular sperm from men with Klinefelter syndrome (KS), whereas reports of children conceived using ejaculated sperm are rare. Objective To review all published cases of children conceived using ejaculated sperm from men with KS, assess their health and karyotype, and evaluate ...
Jens Fedder, Freja Sørensen
wiley   +1 more source

Treatment of idiopathic oligozoospermia with combined human chorionic gonadotropin/human menopausal gonadotrophin: A randomised, double‐blinded, placebo‐controlled clinical study

Andrologia, 2019
To evaluate whether hCG/hMG therapy has beneficial effects on idiopathic oligozoospermia in Chinese infertility population. The patients were randomly divided into the treatment group receiving hCG/hMG for 3 months and the placebo group receiving placebo
Nan Zhao, Xilan Lu, Juntao Li, Jian-Min Zhang   +3 more
semanticscholar   +1 more source