Results 31 to 40 of about 11,390 (207)

Effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with diabetic nephropathy

Medicine, 2022
. Background:. Diabetic nephropathy (DN) is a common microvascular complication of diabetes, which poses a serious threat to the health and life of patients.
Shengfu Jiao, MB, Yuxia Dong, MB, Xiang Chang, MB, Yanan Wu, MB, Haifeng Li, MB   +4 more
doaj   +1 more source

The Preferential Inhibitory Effect of Olmesartan, a New Angiotensin II Type 1 Antagonist, on Sympathetic Nerve Terminals in Isolated Canine Splenic Artery

Journal of Pharmacological Sciences, 2003
Effects of olmesartan (RNH-6270: (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy-4-(1-hydroxy-1-methylethyl)-2-propyl{4-[2-(tetrazol-5-yl)-phenyl]phenyl}methylimidazol-5-carboxylase, an active form of olmesartan medoxomil (CS-866)) was investigated in isolated,
Shigetoshi Chiba, Xiao-Ping Yang
doaj   +1 more source

Calcium channel blockers, more than diuretics, enhance vascular protective effects of angiotensin receptor blockers in salt-loaded hypertensive rats. [PDF]

PLoS ONE, 2012
The combination therapy of an angiotensin receptor blocker (ARB) with a calcium channel blocker (CCB) or with a diuretic is favorably recommended for the treatment of hypertension.
Eiichiro Yamamoto, Keiichiro Kataoka, Yi-Fei Dong, Nobutaka Koibuchi, Kensuke Toyama, Daisuke Sueta, Tetsuji Katayama, Osamu Yasuda, Hisao Ogawa, Shokei Kim-Mitsuyama   +9 more
doaj   +1 more source

Mechanisms With Clinical Implications for Atrial Fibrillation–Associated Remodeling: Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker [PDF]

, 2014
Background: The cysteine protease cathepsin K (CatK) has been implicated in the pathogenesis of cardiovascular disease. We sought to determine the link between atrial fibrillation (AF) and plasma CatK levels and to investigate the expression of and ...
Cheng, Xian Wu, Fujita, Masaya, Inden, Yasuya, Inoue, Aiko, Kuzuya, Masafumi, Kyo, Seifuku, Murohara, Toyoaki, Okumura, Kenji, Shi, Guo‐Ping, Shimano, Masayuki, Taguchi, Noriko, Takeshita, Kyosuke, Yamamoto, Toshihiko, Yoshida, Naoki   +13 more
core   +1 more source

Olmesartan in Management of Proteinuria [PDF]

Journal of Clinical and Diagnostic Research, 2018
Proteinuria is a marker and predictor of cardiovascular morbidity and mortality. Blockade of angiotensin receptor might result in reduction in proteinuria.
Satyanarayan Routray, VN Shah, Abhay Sahoo, Priti Sanghavi, Amit Omprakash Gupta, Onkar C Swami   +5 more
doaj   +1 more source

Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy.

PLoS ONE, 2015
Background and objectivesAnti-hypertensive treatment with the angiotensin II receptor antagonist olmesartan is a rare cause of severe Sprue-like enteropathy. To substantiate the hypothesis that olmesartan interferes with gut immune homeostasis, clinical,
Sophie Scialom, Georgia Malamut, Bertrand Meresse, Nicolas Guegan, Nicole Brousse, Virginie Verkarre, Coralie Derrieux, Elizabeth Macintyre, Philippe Seksik, Guillaume Savoye, Guillaume Cadiot, Lucine Vuitton, Lysiane Marthey, Franck Carbonnel, Nadine Cerf-Bensussan, Christophe Cellier   +15 more
doaj   +1 more source

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

Frontiers in Pharmacology, 2023
Background and aims: Renal damage in severe coronavirus disease 2019 (COVID-19) is highly associated with mortality. Finding relevant therapeutic candidates that can alleviate it is crucial.
Shilin Zhou, Zanzhe Yu, Zihui Chen, Fengling Ning, Xuetao Hu, Tiangang Wu, Mingxue Li, Hong Xin, Svetlana Reilly, Xuemei Zhang   +9 more
doaj   +1 more source

Acute vascular effects of the angiotensin II receptor antagonist olmesartan in normal subjects: relation to the renin-aldosterone system

Кардиоваскулярная терапия и профилактика, 2011
The extent to which the clinical effects of angiotensin receptor blockers (ARB) are related to ambient renin system activity remains poorly defined.
L. M. Resnick, D. Catanzaro, J. E. Sealey, J. H. Laragh   +3 more
doaj   +1 more source

Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study. [PDF]

, 2014
Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness.
Brunel, P, Cardenas, P, Cockcroft, JR, Hester, A, Kario, K, Williams, B, Zappe, DH, Zhang, J   +7 more
core   +1 more source

The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015). [PDF]

, 2016
BACKGROUND: Seronegative villous atrophy (SNVA) is commonly attributed to coeliac disease (CD). However, there are other causes of SNVA. More recently angiotensin-2-receptor-blockers (A2RBs) have been reported as an association but data on SNVA have been
Aziz, I., Barnes, J.H., Cross, S.S., Green, P.H., Kandasamy, V., Partridge, D., Peerally, M.F., Sanders, D.S., Vergani, P., Whiteley, J.C.   +9 more
core   +1 more source