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Effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with diabetic nephropathy [PDF]

open access: yesMedicine, 2022
. Background:. Diabetic nephropathy (DN) is a common microvascular complication of diabetes, which poses a serious threat to the health and life of patients.
Shengfu Jiao, MB   +4 more
doaj   +2 more sources

A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats [PDF]

open access: yesBrazilian Journal of Medical and Biological Research, 2023
There are few studies addressing duodenal inflammation. This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for ...
H.A. Murad, T.M. Alqurashi
doaj   +2 more sources

Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil [PDF]

open access: yesJournal of Chemistry, 2013
Olmesartan medoxomil (1) is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, three process-related impurities were observed along with the final API.
G. Venkanna   +5 more
doaj   +2 more sources

Investigation of hydrolysis of olmesartan medoxomil in different pH buffers by simultaneously measuring olmesartan medoxomil and olmesartan. [PDF]

open access: yesPLoS ONE
Olmesartan medoxomil (OLM) is an ester prodrug of olmesartan (OL) developed to overcome the poor permeability of OL. OLM is an angiotensin receptor blocker and is commonly used to treat hypertension.
Lauren Landry, Xiaowei Dong
doaj   +2 more sources

Antihypertensive efficacy of olmesartan medoxomil and candesartan cilexetil in achieving 24-hour blood pressure reductions and ambulatory blood pressure goals [PDF]

open access: yesКардиоваскулярная терапия и профилактика, 2011
Background. For patients with hypertension, effective 24-hour blood pressure (BP) control is vital to ensure protection against the early morning surge in BP and the associated increased risk of cardiovascular events.
Hans R. Brunner, Kikuo Arakawa
doaj   +2 more sources

Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study [PDF]

open access: yesJournal of Analytical Methods in Chemistry, 2017
A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of pharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in pharmaceutical ...
Ariadne M. Brondi   +2 more
doaj   +2 more sources

Development and validation of stability-indicating RP-HPLC method for determination of Olmesartan medoxomile in pharmaceutical dosage form and identification, characterization of alkaline degradation impurity of Olmesartan medoxomile drug substance as well as drug product [PDF]

open access: yesChemical Industry and Chemical Engineering Quarterly, 2012
Olmesartan Medoxomil (OLME) belongs to a group of angiotensin II receptor blockers used as an antihypertensive agent and is currently being used for prevention of Hypertension.
Jain P.S., Chaudhari A.J., Surana S.J.
doaj   +1 more source

Preparation of Broad-Spectrum Polyclonal Antibody and Development of an Indirect Competitive-Enzyme Linked Immunosorbent Assay for Multi-Residue Detection of Biphenyl Tetrazolium Sartans in Antihypertensive Health Foods [PDF]

open access: yesShipin Kexue, 2023
An indirect competitive-enzyme linked immunosorbent assay (ic-ELISA) was established to detect the multi-residue of biphenyl tetrazolium sartans in antihypertensive health foods. Candesartan was coupled with bovine serum albumin to obtain immunogen.
LIU Fengyin, SU Peiyun, LIN Haobiao, LIU Hui, CHEN Jiayi, LU Zicheng, MU Hongtao, LI Gongke
doaj   +1 more source

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