Results 91 to 100 of about 853 (171)

Drug Resist Updat [PDF]

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new

core  

Clinical significance and antifungal susceptibility profile of 103 clinical isolates of Scedosporium species complex and Lomentospora prolificans obtained from NIH patients

Journal of Clinical Microbiology
Reduced susceptibility to antifungals is common among members of genera Scedosporium and Lomentospora, with optimal treatments still not fully defined.
Mary M. Czech, Jennifer Cuellar-Rodriguez, Kyung J. Kwon-Chung, Frida Stock, Chioma I. Aneke, Kenneth N. Olivier, Kevin P. Fennelly, Juan Gea-Banacloche, Christa S. Zerbe, Alexandra F. Freeman, Steven M. Holland, Michail S. Lionakis, Amir Seyedmousavi   +12 more
doaj   +1 more source

American Society of Transplantation and Cellular Therapy Series: #8-Management and Prevention of Non-Aspergillus Molds in Hematopoietic Cell Transplantation Recipients. [PDF]

The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to create a guideline focusing on non-Aspergillus invasive molds, which are uncommon
Carpenter, P.A., Chemaly, R.F., Dadwal, S.S., Douglas, A.P., Groll, A.H., John, T.M., Kontoyiannis, D.P., Lamoth, F., Papanicolaou, G.A., Shigle, T.L., Walsh, T.J.   +10 more
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Dihydroorotate dehydrogenase inhibitor olorofim exhibits promising activity against all clinically relevant species within Aspergillus section Terrei

Journal of Antimicrobial Chemotherapy, 2018
In vitro and in vivo activity of the dihydroorotate dehydrogenase inhibitor olorofim (formerly F901318) (F2G Limited, UK) against clinically relevant species of the Aspergillus section Terrei was evaluated.A total of 92 clinical Aspergillus section Terrei isolates [42 Aspergillus terreus sensu stricto and 50 cryptic species: Aspergillus alabamensis (n =
Michaela, Lackner, Mike, Birch, Verena, Naschberger, Denise, Grässle, Nicola, Beckmann, Peter, Warn, Julie, Gould, Derek, Law, Cornelia, Lass-Flörl, Ulrike, Binder   +9 more
openaire   +2 more sources

Antifungal Agents in the 21st Century: Advances, Challenges, and Future Perspectives

Infectious Disease Reports
Invasive fungal infections (IFIs) represent a growing global health threat, particularly for immunocompromised populations, with mortality exceeding 1.5 million deaths annually.
Francesco Branda, Nicola Petrosillo, Giancarlo Ceccarelli, Marta Giovanetti, Andrea De Vito, Giordano Madeddu, Fabio Scarpa, Massimo Ciccozzi   +7 more
doaj   +1 more source

Accelerating the understanding of Aspergillus terreus: Epidemiology, physiology, immunology and advances

Current Research in Microbial Sciences
Aspergillus species encompass a variety of infections, ranging from invasive aspergillosis to allergic conditions, contingent upon the immune status of the host.
Raman Thakur, Sonia Kumari Shishodia, Ananya Sharma, Arjun Chauhan, Sumanpreet Kaur, Jata Shankar   +5 more
doaj   +1 more source

P-1239. Systemic Exposure of Olorofim in Children with Invasive Fungal Infections [PDF]

Open Forum Infect Dis
Abstract Background Olorofim (OLO) is a novel antifungal active vs. Aspergillus (including azole-resistant strains), resistant moulds (e.g., Lomentospora prolificans [LoPro]), and dimorphic moulds.
Cornelissen, Karen, Rex, John H, Zinzi, Daniela, Bruggemann, Roger, Wright, James   +4 more
europepmc   +2 more sources

Susceptibility Testing of Environmental and Clinical Aspergillus sydowii Demonstrates Potent Activity of Various Antifungals [PDF]

The genus Aspergillus consists of a vast number of medically and environmentally relevant species. Aspergillus species classified in series Versicolores are ubiquitous in the environment and include the opportunistic pathogen Aspergillus sydowii, which ...
de Groot, Theun, Hagen, Ferry, Houbraken, Jos, Meijer, Eelco F.J., Meis, Jacques F., Rezusta, Antonio, Spruijtenburg, Bram   +6 more
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Talaromyces marneffei, Coccidioides species, and Paracoccidioides species-a systematic review to inform the World Health Organization priority list of fungal pathogens. [PDF]

The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal pathogen priority list. This systematic review aimed to evaluate the epidemiology and impact of infections caused by Talaromyces
Alastruey-Izquierdo, A, Alffenaar, J-W, Beardsley, J, Bongomin, F, Chakrabarti, A, Chiller, TM, Colombo, AL, Dagne, DA, Dao, A, Forastiero, A, Galas, M, Gigante, V, Harrison, TS, Heim, J, Kim, HY, Le, T, McMullan, B, Morris, AJ, Morrissey, CO, Nield, B, Roitberg, F, Sati, H, Siswanto, S, Wahyuningsih, R   +23 more
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Additional file 1 of Review of the novel antifungal drug olorofim (F901318)

Supplementary Material ...
Vanbiervliet, Yuri, Van Nieuwenhuyse, Tine, Aerts, Robina, Lagrou, Katrien, Spriet, Isabel, Maertens, Johan   +5 more
openaire   +1 more source