Results 161 to 170 of about 895 (178)

Prolonged Remission of Azole-Resistant Lung Aspergillosis with Olorofim, in an Adolescent with X-Linked Chronic Granulomatous Disease

Journal of Clinical Immunology, 2023
Little is known about localized osteoarticular Scedosporiosis (LOS). Most data come from case reports and small case series. Here we present an ancillary study of the nationwide French Scedosporiosis Observational Study (SOS), describing 15 consecutive cases of LOS diagnosed between January 2005 and March 2017. Adult patients diagnosed with LOS defined
Michel, Victor, Mahlaoui, Nizar, Bougnoux, Marie Elisabeth, Garcia-Hermoso, Dea, Lanternier, Fanny, Lévy, Romain   +5 more
openaire   +2 more sources

Antagonistic in vitro interaction between olorofim and voriconazole against Aspergillus fumigatus

Journal of Antimicrobial Chemotherapy
Abstract Background and objectives The emergence of azole resistance among Aspergillus fumigatus isolates has driven the development of novel antifungal compounds, which may potentially be used in combination with existing antifungal drugs.
Illan Laloum, Anne-Laure Bidaud, Elise Recalt, Patrick Schwarz, Marie-Elisabeth Bougnoux, Eric Dannaoui   +5 more
openaire   +1 more source

F2G gets $70 million to develop the antifungal olorofim

Chemical & Engineering News, 2022
openaire   +1 more source

In vitro activity of olorofim against Aspergillus fumigatus sensu lato clinical isolates: activity is retained against isolates showing resistance to azoles and/or amphotericin B

Clinical Microbiology and Infection, 2022
Pilar Escribano Martos, Elena Reigadas, Jesus Guinea   +2 more
exaly  

Olorofim activity against multidrug-resistant unveils intra-species and inter-species variability.

Fungi in the genus are plant pathogens but are also capable of causing a wide range of diseases in humans. The intrinsic multi-drug resistance of often leads to a poor clinical outcome in patients with severe immune disorders. Olorofim, a member of the orotomide class, is a novel type of antifungal drug that interferes with pyrimidine biosynthesis by ...
Xue, Ruoning, Gao, Shenghan, de Hoog, Sybren, van Diepeningen, Anne, Zhou, Shaoqin, Xu, Tianyi, Fokkens, Like, Li, Ruoyu, Bai, Lin, Wan, Zhe, Verweij, Paul E, Song, Yinggai   +11 more
openaire   +1 more source

Screening of Pandemic Response Box Library Reveals the High Activity of Olorofim against Pathogenic Sporothrix Species

Journal of Fungi (Basel, Switzerland), 2022
Luana Pereira Borba-Santos, Rodrigo Rollin-Pinheiro, Yasmin da Silva Fontes   +2 more
exaly  

Potency of Olorofim (F901318) Compared to Contemporary Antifungal Agents against Clinical Aspergillus fumigatus Isolates and Review of Azole Resistance Phenotype and Genotype Epidemiology in China

Antimicrobial Agents and Chemotherapy, 2021
Huilin Su, Jan Zoll, Tobias G P Engel
exaly  

Absorption, Metabolism and Excretion of 14C-olorofim in Man

Case Medical Research, 2019
openaire   +1 more source

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi (Basel, Switzerland), 2020
Saskia du Pré, Michael J Bromley, Nick D Read   +2 more
exaly  

In vitro activity of olorofim (F901318) against fungi of the genus, Scedosporium and Rasamsonia as well as against Lomentospora prolificans, Exophiala dermatitidis and azole-resistant Aspergillus fumigatus

International Journal of Antimicrobial Agents, 2020
Lisa Kirchhoff, Jan J Buer, Joerg Steinmann   +2 more
exaly