A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii [PDF]
Frontiers in MicrobiologyBackgroundCarbapenem-resistant Acinetobacter baumannii (CRAB)-caused severe pneumonia is associated with high mortality rates, and treatment options are limited.
Dayu Chen +9 more
doaj +4 more sources
A real-world pharmacovigilance analysis of omadacycline in FDA adverse event reporting system (FAERS) database [PDF]
Frontiers in PharmacologyObjectiveOmadacycline is a newly launched drug of tetracycline. Therefore, it is necessary to comprehensive evaluate reports on the safety of omadacycline in large, real-world populations.
Xueping Shi +4 more
doaj +4 more sources
LC-MS/MS quantification of omadacycline in human plasma for therapeutic drug monitoring: method development and clinical application [PDF]
Scientific ReportsOmadacycline, a third-generation tetracycline antibiotic, exhibits time-dependent pharmacokinetics. The ratio of the 24-hour area under the concentration-time curve to minimum inhibitory concentration (AUC0−24/MIC) serves as the primary pharmacokinetic ...
Yueyuan Wang +7 more
doaj +4 more sources
In vitro activity and in vivo efficacy of omadacycline against Plasmodium species [PDF]
Malaria JournalBackground Doxycycline is currently the only tetracycline-class antibiotic recommended for malaria prophylaxis. Omadacycline, a semisynthetic aminomethylcycline approved for treatment of adults with community-acquired bacterial pneumonia and acute ...
Michael S. Madejczyk +9 more
doaj +4 more sources
Omadacycline Is Highly Active In Vitro against Mycoplasma genitalium
Microbiology Spectrum, 2022 Here, we performed in vitro susceptibility testing on 10 Mycoplasma genitalium isolates against omadacycline, minocycline, tetracycline, doxycycline, moxifloxacin, levofloxacin, and azithromycin.
Ken B. Waites +4 more
doaj +2 more sources
Prepared omadacycline for injection: Nine-day stability and sterility in an elastomeric pump
SAGE Open Medicine, 2022 Objective: To investigate compatibility, stability, and microbiologic risk of omadacycline 1 mg/mL when prepared in an elastomeric infusion pump and stored under refrigeration for 9 days based upon requests for information from healthcare providers ...
Jason Bower +2 more
doaj +2 more sources
Case Report: Omadacycline in the Treatment of Community‐Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies [PDF]
Clinical Case ReportsOmadacycline, a novel once‐daily aminomethylcycline antibiotic agent, demonstrates efficacy against prevalent pathogens responsible for community‐acquired pneumonia (CAP) in adults.
Ziqi Xu +6 more
doaj +2 more sources
Omadacycline versus moxifloxacin for community-acquired bacterial pneumonia (OPTIC-2): a phase 3b, randomised, double-blind, multicentre, controlled, noninferiority trialResearch in context [PDF]
EClinicalMedicineSummary: Background: Omadacycline is a first-in-class aminomethylcycline antibiotic approved to treat adults with community-acquired bacterial pneumonia (CABP).
Thomas M. File, Jr. +12 more
doaj +2 more sources
Omadacycline Pharmacokinetics: Characteristics, Contributing Factors, and Clinical Significance [PDF]
Drugs in R&DOmadacycline is a novel tetracycline with a wide range of antibacterial activity. A comprehensive understanding of the factors influencing its metabolic processes is essential to optimize its therapeutic benefits and minimize any potential negative ...
Huan Sun +5 more
doaj +2 more sources
Efficacy and safety of omadacycline for the treatment of infectious diseases: a real-world, retrospective study of 2587 patients [PDF]
Frontiers in PharmacologyObjectivePrevious randomized controlled trials have shown good efficacy and safety of omadacycline in patients with infectious diseases, but relevant real-world evidence is still insufficient.
Jian Liu +7 more
doaj +2 more sources