Results 241 to 250 of about 165,835 (344)

FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice

Zheping Chen, Qianqian Wu, Jiahui Ma, Yufei Shi, Qian Zhang, Huanghui Wu, Yuxin Zhang, Zhouxiang Li, Xianghan Ruan, Lize Xiong, Peilin Cong, Li Tian   +11 more
openalex   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Omega-6 polyunsaturated fatty acids and coronary heart disease [PDF]

The American Journal of Clinical Nutrition, 2009
openaire   +2 more sources

Dietary Omega-3 Fatty Acid, Ratio of Omega-6 to Omega-3 Intake, Inflammation, and Survival in Long-term Hemodialysis Patients

, 2011
Nazanin Noori, Ramanath Dukkipati, Csaba P. Kövesdy, John J. Sim, Usama Feroze, Sameer B. Murali, Rachelle Bross, Debbie Benner, Joel D. Kopple, Kamyar Kalantar‐Zadeh   +9 more
openalex   +2 more sources

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Metabolic engineering of adipose‐derived stem cell exosomes via arachidonic acid potentiates diabetic wound repair by orchestrating angiogenesis: A multi‐omics guided strategy

VIEW, EarlyView.
AA‐Exos promotes angiogenesis and accelerates diabetic wound healing by activating the PI3K/AKT/mTOR pathway. Abstract Diabetic wounds are common and challenging complications of diabetes, characterized by delayed healing and an increased risk of infection.
Yujiao Cai, Jinnan Wang, Yan Liu, Xiaoke Zhu, Zhanyuan Yuan, Weiling Li, Dehui Che, Dongsheng Cao   +7 more
wiley   +1 more source

Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure

, 2016
Toshiyuki Nagai, Yasuyuki Honda, Yasuo Sugano, Kunihiro Nishimura, Michikazu Nakai, Satoshi Honda, Naotsugu Iwakami, Atsushi Okada, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Kengo Kusano, Hisao Ogawa, Satoshi Yasuda, Toshihisa Anzai, NaDEF investigators   +15 more
openalex   +2 more sources

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, EarlyView.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source