Results 31 to 40 of about 931,677 (304)

Statistical indices from bifactor models

Interacciones, 2017
Many instruments are created with the primary purpose of scaling individuals on a single trait. However psychological traits are often complex and contain domain specific manifestations.
Sergio Alexis Dominguez-Lara, Anthony Rodriguez   +1 more
doaj   +1 more source

A single centre, real world experience of T-DM1 in the treatment of HER2-positive metastatic breast cancer patients in India

Journal of Applied Pharmaceutical Research
Background: HER2 (Human Epidermal Growth Receptor 2) positive breast cancer is an aggressive subtype. Treatment for patients with HER2-positive breast cancer has advanced significantly over time with the introduction of targeted therapies like ...
Vindhya Vasini, Mohana Vamsy, Monal Dayal, Pawan Shinkar   +3 more
doaj   +1 more source

Next-generation sequencing of drug resistant Mycobacterium tuberculosis clinical isolates in low-incidence countries

Инфекция и иммунитет, 2020
Drug resistant tuberculosis (TB), especially multidrug (MDR) and extensively drug-resistant (XDR) TB, is still a serious problem in global TB control.
E. Sodja, N. Toplak, S. Koren, M. Kovač, S. Truden, M. Žolni-Dovč   +5 more
doaj   +1 more source

Traces and Extensions of Bounded Divergence-Measure Fields on Rough Open Sets

, 2020
We prove that an open set $\Omega \subset \mathbb{R}^n$ can be approximated by smooth sets of uniformly bounded perimeter from the interior if and only if the open set $\Omega$ satisfies \begin{align*} &\qquad \qquad\qquad\qquad\qquad\qquad\qquad ...
Chen, Gui-Qiang G., Li, Qinfeng, Torres, Monica   +2 more
core   +1 more source

Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases

Nature Communications
Pathogenic gene dysregulation can be attributed to chromatin state change that pre-transcriptionally regulates expression. Recent breakthroughs elucidating the rules governing this DNA control layer, an epigenetic code, unlock a modality in precision ...
Charles W. O’Donnell, Jeremiah D. Farelli, Houda Belaghzal, Justin Chen, Lauren Beech, James Sullivan, Chevaun Morrison-Smith, Stephen Siecinski, Adam Katz, Samuel Mildrum, Mayur Gurnani, Prachi Dhanania, Caitlyn R. Webb, Giuliana Castello Coatti, Pranjali Rumale, Daniel F. G. Costa, Marcus I. Gibson, Yaoyu E. Wang, Joseph V. Newman, Thomas G. McCauley   +19 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

EFEKTIVITAS KOMBINASI DL-αTOKOFEROL DAN ASAM ASKORBAT TERHADAP KADAR LDL-OX, sCD36, sVCAM-1 DAN NO PADA ANAK SINDROM NEFROTIK [PDF]

, 2015
Latar Belakang: Stres oksidatif, disfungsi endotel dan inflamasi mendasari proses aterosklerosis pada anak sindrom nefrotik (SN). Kombinasi dl-α-tokoferol dan asam askorbat berpotensi menurunkan proses stress oksidatif dan disfungsi endotel banyak ...
MELLYANA, Omega
core  

Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models

Nature Communications
Dysregulation of master regulator c-MYC (MYC) plays a central role in hepatocellular carcinoma (HCC) and other cancers but remains an elusive target for therapeutic intervention.
William Senapedis, Kayleigh M. Gallagher, Elmer Figueroa, Jeremiah D. Farelli, Robert Lyng, J. Graeme Hodgson, Charles W. O’Donnell, Joseph V. Newman, Madison Pacaro, Stephen K. Siecinski, Justin Chen, Thomas G. McCauley   +11 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Morphodynamics of carbonate beaches in the Yucatán Peninsula

Ciencias Marinas, 2009
The concept of beach morphodynamics was used to classify the swash zone of carbonate sandy beaches in the central part of the state of Yucatán (Mexico).
A Cuevas-Jiménez, J Euán-Avila
doaj   +1 more source