Results 51 to 60 of about 738,019 (325)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Marine Drugs, 2018 The high-fat diet of North Americans has a major impact on cardiovascular disease occurrence. Notably, fatty acids have been identified as important factors that could modulate such diseases, especially myocardial infarction (MI). Experimentally, omega-3
Melissa Desnoyers +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Frontiers in Nutrition, 2022 BackgroundAccumulating evidence has demonstrated the associations of omega-3 or omega-6 polyunsaturated fatty acids (PUFAs) with the disease activity and inflammatory mediators of systemic lupus erythematosus (SLE), but the evidence of causal links of ...
Peng Wang +12 more
doaj +1 more source
Fano congruences of index $3$ and alternating $3$-forms [PDF]
, 2017 We study congruences of lines $X_\omega$ defined by a sufficiently general choice of an alternating 3-form $\omega$ in $n+1$ dimensions, as Fano manifolds of index $3$ and dimension $n-1$.
De Poi, Pietro +3 more
core +7 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Nutrition JournalBackground Lipedema is a chronic female disease characterized by a painful accumulation of adipose tissue in the limbs. Plasma fatty acid (FA) composition has been proposed as a potential modulator of pain.
Julianne Lundanes +6 more
doaj +1 more source
$pp\to pp\omega$ reaction near threshold
, 1999 We analyze the total cross section data for $pp \to pp\omega$ near threshold measured recently at SATURNE. Using an effective range approximation for the on-shell $pp$ S-wave final state interaction we extract from these data the modulus $|\Omega| = 0.53$
F. Hibou +13 more
core +2 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Relación de Ácidos grasos Omega 6 /Omega 3
Revista Digital de Postgrado, 2014 La relación de ácidos grasos (AG)ω6/ω3 de ladieta contemporánea favorece a los AG ω6. El objetivodel estudio fue evaluar el efecto de dietas concantidades crecientes de aceite de pescado (AcP),rico en AG ω3, sobre el crecimiento y las ...
Zury Dominguez
doaj