Results 111 to 120 of about 49,863 (275)

Combined Metabolomics to Reveal the Beneficial Efficacy and Mechanism of Ripe Pu‐erh Tea in Alleviating Alcohol‐Induced Acute Gastric Injury in Mice

eFood, Volume 6, Issue 6, December 2025.
PTE ameliorates alcohol‐induced gastric injury by regulating oxidative stress and inflammatory responses. Activation of the Keap1/Nrf2/HO‐1 pathway and suppression of NF‐κB pathway may represent the molecular mechanisms by which PTE mediates antioxidative and anti‐inflammatory effects.
Mianhong Xu, Sibo Zhao, Jielin Jiang, Yan Liu, Liyong Luo, Liang Zeng   +5 more
wiley   +1 more source

Assessment of toxicity and oxidative stress associated with omeprazole in Caenorhabditis elegans

Acta Scientiarum: Biological Sciences
Omeprazole is an inhibitor of the proton pump which has been extensively studied presently due to the evidence of a potential toxicity related to the generation of reactive species of oxygen (ROS) to its chronic users.
Gabriela Endres da Rocha Pompeo, Roberta Rodrigues Zorzo, Bianca Bordignon Fraga, Mariele Feiffer Charão, Magda Susana Perassolo   +4 more
doaj   +1 more source

Continuous infusion of high‐dose omeprazole is more effective than standard‐dose omeprazole in patients with high‐risk peptic ulcer bleeding: a retrospective study [PDF]

, 2007
M. Simon-Rudler, Julien Massard, Brigitte Bernard‐Chabert, Vincent Di Martino, Vlad Ratziu, Thierry Poynard, Dominique Thabut   +6 more
openalex   +1 more source

Tongjiang Hewei Decoction Improves Airway Hyperresponsiveness in Gastroesophageal Reflux Cough by Inhibiting ADAM33 and Epac1/Rap1 Pathway

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
THD reduced lung resistance and attenuated bronchial wall thickening, mucus hypersecretion, and inflammatory infiltration in a dose‐dependent manner. Mechanistically, THD suppressed ADAM33, RhoA/ROCK, and Epac1/Rap1 pathways in vivo, correlating with reduced α‐SMA and sm‐MHC expression.
Xiulian Zhang, Xueliang Li, Yanmei Cheng, Lei Wei, Fangying Liu, Li Li, Wei Zhang, Xiuli Yan   +7 more
wiley   +1 more source

Preanaesthetic oral ranitidine, omeprazole and metoclopramide for modifying gastric fluid volume and pH [PDF]

, 1994
Satinder Gombar, Shashi Kiran, Mahesh Gupta, K. K. Gombar, Balbir Chhabra   +4 more
openalex   +1 more source

Exposure–Response Modeling and Simulation to Identify Optimal Mavacamten Posology When Coadministered with CYP3A4 and CYP2C19 Inhibitors in Patients with Obstructive HCM

The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1802-1814, December 2025.
Abstract Mavacamten, a cardiac myosin inhibitor, is primarily metabolized by the cytochrome P450 (CYP) enzymes CYP2C19 and CYP3A4, and coadministration with strong CYP3A4 or CYP2C19 inhibitors was contraindicated in patients with obstructive hypertrophic cardiomyopathy (HCM) in the US Prescribing Information. This study assessed the safety and efficacy
Samira Merali, Haden Bunn, Caroline Sychterz, Manting Chiang, Shilpa Puli, Amy J. Sehnert, Bindu Murthy, Joga Gobburu   +7 more
wiley   +1 more source

Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant–randomized controlled trial

Frontiers in Pharmacology
Tacrolimus is metabolized in the liver with the participation of the CYP3A4 and CYP3A5 enzymes. Proton pump inhibitors are used in kidney transplant patients to prevent duodenal and gastric ulcer disease due to glucocorticoids.
Miłosz Miedziaszczyk, Marek Karczewski, Tomasz Grabowski, Anna Wolc, Anna Wolc, Ilona Idasiak-Piechocka   +5 more
doaj   +1 more source

Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma [PDF]

, 2009
José R. Cortés, María Dolores Megías Rivas, Javier Molina‐Infante, González Núñez, Moises Perez-G, Juan F. Masa, Juan F. Sánchez, José Luis Zamorano   +7 more
openalex   +1 more source

Hydroxylation index of omeprazole in relation to CYP2C19 polymorphism and sex in a healthy Iranian population [PDF]

, 2014
Maryam Payan, Mohammad Reza Rouini, Nader Tajik, Mohammad Hossein Ghahremani, Reza Tahvilian   +4 more
openalex   +1 more source

Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms

MedComm, Volume 6, Issue 12, December 2025.
Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun, Changjian Shao, Hongtao Duan, Zhaoyang Wang, Shaopeng Xu, Chao Wang, Jiawei Xiu, Jin Liu, Xuejiao Wang, Xin Yao, Yuan Gao, Xiaolong Yan   +11 more
wiley   +1 more source