Results 111 to 120 of about 50,234 (263)

Efficacy and Safety of Omeprazole and Amoxicillin in the Treatment of Gastric Ulcer

, 2021
Jie Liu, Minghui Xiao, Jianping Hui
openalex   +2 more sources

Recurrent haemorrhage, due to vitamin K‐dependent coagulopathy, as the primary presenting complaint in a dog with naturally occurring hypoadrenocorticism

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 5‐year‐old male neutered standard poodle, presented with recurrent gingival margin haemorrhage and associated prolongations in prothrombin time and activated partial thromboplastin time, with repeatable demonstration of clinical (bleeding) and laboratory (prothrombin time, activated partial thromboplastin time) resolution with, and relapse ...
Jenny Reeve, Aiden Pang
wiley   +1 more source

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant–randomized controlled trial

Frontiers in Pharmacology
Tacrolimus is metabolized in the liver with the participation of the CYP3A4 and CYP3A5 enzymes. Proton pump inhibitors are used in kidney transplant patients to prevent duodenal and gastric ulcer disease due to glucocorticoids.
Miłosz Miedziaszczyk, Marek Karczewski, Tomasz Grabowski, Anna Wolc, Anna Wolc, Ilona Idasiak-Piechocka   +5 more
doaj   +1 more source

The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith, Danielle Graden, Lauren L. R. Lohmer, Joy Schleyer, Stephen P. Wanaski   +4 more
wiley   +1 more source

Acute hepatitis and haemolysis associated with doxycycline and rifampin administration in two weanling foals

Equine Veterinary Education, Volume 38, Issue 2, Page e70-e77, February 2026.
Summary Two foals were being treated with a combination of oral doxycycline and rifampin for presumed Rhodococcus equi infections. After 3–4 weeks of antimicrobial administration, both foals presented with icterus and nonspecific clinical signs, including lethargy and inappetence.
A. Murdock, D. Wong, T. Hall, B. Sponseller, J. Howard, K. Frerichs, A. Bianco, R. Ruby   +7 more
wiley   +1 more source

Development and validation of a reversed-phase HPLC-UV method for simultaneous determination of levosulpiride and omeprazole in human plasma: Applicability of the method for evaluation of pharmacokinetic drug-drug interactions.

PLoS ONE
Levosulpiride and omeprazole are co-prescribed for gastrointestinal disorders associated with depression and anxiety. Objective of the study was to develop a sensitive, robust and simple method for simultaneous analysis of levosulpiride and omeprazole in
Muhammad Hashim, Lateef Ahmad, Amjad Khan, Muhammad Faheem   +3 more
doaj   +1 more source

‘How Does Nothing Show Up When I'm in So Much Agony?’: A Qualitative Study Exploring Patient Experiences of Non‐Specific Abdominal Pain in Acute Surgical Care

Health Expectations, Volume 29, Issue 1, February 2026.
ABSTRACT Introduction Non‐specific abdominal pain is a common and diagnostically challenging presentation in acute care, yet little is known about patient experiences within this setting. This study explores the experiences of patients attending a surgical same‐day emergency care (SDEC) unit with non‐specific abdominal pain.
Anna Kathryn Taylor, Daniel Romeu, Jess Dodd, Catherine Moriarty, Adam Peckham‐Cooper, Max Henderson, Elspeth Guthrie, Giles Toogood   +7 more
wiley   +1 more source

Evaluation of gastric pH-dependent drug interaction between famitinib and the commonly used proton pump inhibitor omeprazole in healthy subjects [PDF]

, 2022
Linlin Hu, Mingmin Cai, Wei Qian, Ting Dou, Qiuyue Sun, Lu Tang, Huiping Wang   +6 more
openalex   +1 more source

Activity of Fluoroquinolones and Proton Pump Inhibitors against Resistant Oral Bacterial Biofilms, in silico and in vitro Analysis

Polish Journal of Microbiology
Oral bacterial infections are a great health concern worldwide especially in diabetic patients. Emergence of antimicrobial resistance with reference to biofilms in oral cavity is of great concern.
Kamran Muhammad, Raza Muhammad, Ullah Riaz, Alotaibi Amal, Bano Ràheela, Zaman Ali, Chaman Sadia, Iqbal Kashif, Rasool Shahid, Amin Adnan   +9 more
doaj   +1 more source