Results 31 to 40 of about 49,863 (275)

Efficacy of transoral fundoplication vs omeprazole for treatment of regurgitation in a randomized controlled trial.

Gastroenterology, 2015
BACKGROUND & AIMS Transoral esophagogastric fundoplication (TF) can decrease or eliminate features of gastroesophageal reflux disease (GERD) in some patients whose symptoms persist despite proton pump inhibitor (PPI) therapy.
J. Hunter, P. Kahrilas, R. Bell, Erik B. Wilson, K. Trad, J. P. Dolan, K. Perry, B. Oelschlager, N. Soper, Brad E. Snyder, M. Burch, W. Melvin, K. Reavis, Daniel Turgeon, Eric S. Hungness, B. Diggs   +15 more
semanticscholar   +1 more source

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats

Pharmaceutical Biology, 2019
Context: Omeprazole and astragaloside IV (AS-IV) are widely used for the treatment of gastric ulcers in China clinics. Objective: This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats.
Wei Liu, Guozhi Liu, Jing Liu
doaj   +1 more source

Changes in omeprazole pharmacokinetics in rats with diabetes induced by alloxan or streptozotocin: Faster clearance of omeprazole due to induction of hepatic CYP1A2 and 3A1

Journal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. To investigate the effect of diabetes mellitus induced by alloxan (DMIA) or streptozotocin (DMIS) on the pharmacokinetics of omeprazole in rats.
Dae Young Lee, Myung G. Lee, Hyun Sook Shin, Inchul Lee   +3 more
doaj   +1 more source

In vivo and in vitro protective effects of omeprazole against neuropathic pain

Scientific Reports, 2016
Apart from reducing the acid secretion, omeprazole inhibits activation of the nuclear factor-κB, release of inflammatory cytokines and chemotaxis of neutrophils. These mechanisms prompted us to evaluate antineuropathic effect of omeprazole in the chronic
Sanjay K. Chanchal, U. Mahajan, S. Siddharth, N. Reddy, S. Goyal, P. Patil, B. Bommanahalli, C. Kundu, Chandragouda R. Patil, S. Ojha   +9 more
semanticscholar   +1 more source

Binding of omeprazole to protein targets identified by monoclonal antibodies.

PLoS ONE, 2020
Omeprazole is the most commonly used proton pump inhibitor (PPI), a class of medications whose therapeutic mechanism of action involves formation of a disulfide linkage to cysteine residues in the H+/K+ ATPase pump on gastric secretory cells.
Naw May Pearl Cartee, Michael M Wang
doaj   +2 more sources

Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study

Frontiers in Pharmacology
Grapes have been widely used for dietary ailments due to their attributed pharmacological activities. Resveratrol, the chief constituent of grapes, is responsible for their pharmacological benefits.
Tayyaba Iftikhar, Zafar Iqbal, Yasar Shah, Nauman Rahim Khan, Muhammad Abbas, Omer Shehzad, Fazal Hadi, Haseeba Sardar, Ali Abusharha, Maria Daglia, Maria Daglia, Haroon Khan, Haroon Khan   +12 more
doaj   +1 more source

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH

BMC Gastroenterology, 2012
Background The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms.
Iida Hiroshi, Inamori Masahiko, Fujii Tetsuro, Sekino Yusuke, Endo Hiroki, Hosono Kunihiro, Nonaka Takashi, Koide Tomoko, Takahashi Hirokazu, Yoneda Masato, Goto Ayumu, Abe Yasunobu, Kobayashi Noritoshi, Kirikoshi Hiroyuki, Kubota Kensuke, Saito Satoru, Gotoh Eiji, Maeda Shin, Nakajima Atsushi   +18 more
doaj   +1 more source

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. [PDF]

Pharmacoepidemiol Drug Saf
ABSTRACT Background Medications associated with acute liver injury (ALI) are primarily identified by case reports. High‐throughput screening of real‐world data could be leveraged to detect hepatotoxicity signals. Objective To apply tree‐based scan statistics in real‐world data to identify drugs associated with hospitalization for severe ALI among ...
Lo Re V, Newcomb CW, Carbonari DM, Leonard CE, Rentsch CT, Maro JC.   +5 more
europepmc   +2 more sources

Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers

Journal of Korean medical science, 2017
The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses.
Sunny Park, Y. Hyun, Y. Kim, J. H. Lee, S. Ryu, Jeong Mi Kim, W. Oh, H. Na, Jong Gu Lee, D. Seo, I. Y. Hwang, Z. Park, I. Jang, Jaeseong Oh, S. Choi   +14 more
semanticscholar   +1 more source

Induction of Erythrocyte Shrinkage by Omeprazole

Dose-Response, 2020
Omeprazole, a proton pump inhibitor blocks the H + /K + -ATPase channels of gastric parietal cells. It is used for the treatment of peptic ulcer. Prolonged use of omeprazole may involve in inducing anemia.
Ayesha Naveed, Kashif Jilani, Abu Bakar Siddique, Muhammad Akbar, Muhammad Riaz, Zahid Mushtaq, Muhammad Sikandar, Sajida Ilyas, Ismat Bibi, Asma Asghar, Ghulam Rasool, Muhammad Irfan   +11 more
doaj   +1 more source