Results 61 to 70 of about 49,863 (275)

Comparative efficacy of esomeprazole and omeprazole: Racemate to single enantiomer switch

DARU Journal of Pharmaceutical Sciences, 2015
BackgroundBoth omeprazole and its S enantiomer (esomeprazole) have been available and used to treat  symptoms of gastroesophageal reflux disease (GERD) and conditions associated with excessive stomach acid secretion for more than a decade.
Waheed Asghar, Elliot Pittman, F. Jamali
semanticscholar   +1 more source

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, EarlyView.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of (R)‐ and (S)‐omeprazole and intragastric pH

CPT: Pharmacometrics & Systems Pharmacology
This study employed physiologically‐based pharmacokinetic–pharmacodynamics (PBPK/PD) modeling to predict the effect of obesity and gastric bypass surgery on the pharmacokinetics and intragastric pH following omeprazole treatment.
Leandro F. Pippa, Valvanera Vozmediano, Lieke Mitrov‐Winkelmolen, Daan Touw, Amira Soliman, Rodrigo Cristofoletti, Wilson Salgado Junior, Natalia Valadares de Moraes   +7 more
doaj   +1 more source

Omeprazole Inhibits Cell Proliferation and Induces G0/G1 Cell Cycle Arrest through Up-regulating miR-203a-3p Expression in Barrett’s Esophagus Cells

Frontiers in Pharmacology, 2018
Existing data suggest that proton pump inhibitors (PPIs), particularly omeprazole, have significant anti-tumor action in monotherapy and or combination chemotherapy.
Yichao Hou, Qiang Hu, Jiao Huang, Hua Xiong   +3 more
doaj   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Cardiovascular Outcomes Associated With Clinical Use of Citalopram and Omeprazole: A Nationwide Population‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Recent studies have raised concerns about the reduced efficacy of citalopram when used concurrently with proton pump inhibitors. The aim of this study was to evaluate the associations between clinical use of citalopram and omeprazole and the ...
Wen‐Tung Wu, Chun‐Teng Tsai, Yu‐Ching Chou, Po‐Ming Ku, Yong‐Chen Chen, San‐Lin You, Chi‐Feng Hung, Chien‐An Sun   +7 more
doaj   +1 more source

The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis

BMC Cancer, 2014
BackgroundPatients with ER-negative breast tumors are among the most difficult to treat and exhibit low survival rates due, in part, to metastasis from the breast to various distal sites.
U. Jin, Syng-Ook Lee, C. Pfent, S. Safe
semanticscholar   +1 more source

Healthcare resource utilization and cost in pediatric celiac disease: A case‐control study using German insurance data

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Celiac disease (CeD) is a life‐long systemic immune‐mediated disorder. Data on burden and cost of CeD in children are scarce. We assessed healthcare resource utilization (HCRU) and cost of healthcare services of newly diagnosed children in Germany.
Sibylle Koletzko, Svitlana Schnaidt, Leonarda Serdani‐Neuhaus, Juliane Sünwoldt, Christina Dünweber, Bernd Bokemeyer   +5 more
wiley   +1 more source

Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high-performance liquid chromatography

Journal of Pharmacy and Bioallied Sciences, 2011
Omeprazole is widely prescribed in the form of enteric-coated formulations, due to the rapid degradation of the drug in the acidic condition of the stomach.
Samir Vyas, Ajay Patel, Kartik D Ladva, H S Joshi, Atul H Bapodra   +4 more
doaj   +1 more source

Muscular and serosal eosinophilic gastritis and enteritis with eosinophilic ascites successfully treated with dupilumab

JPGN Reports, EarlyView.
Abstract Primary eosinophilic gastrointestinal disorders beyond the esophagus (EGIDs) are rare, predominantly Th2‐mediated inflammatory conditions, affecting various segments of the gastrointestinal tract. We report the case of a 12‐year‐old boy with recurrent abdominal pain, peripheral eosinophilia, and progressive gastritis, duodenitis, and enteritis
Almudena Sánchez‐Ramírez, Alejandro García‐Díaz, Ruth García‐Martínez de Bartolomé, Maria Isabel García‐Hidalgo, Maria Luz Cilleruelo, Enriqueta Román‐Riechmann, Carolina Gutiérrez‐Junquera   +6 more
wiley   +1 more source