Results 71 to 80 of about 49,863 (275)

A Randomized, Double‐Blind, Placebo‐Controlled Pilot Trial With Open‐Label Extension of Sirona, a Hydrogel for Weight Loss

Obesity, EarlyView.
ABSTRACT Objective This study investigated the safety, tolerability, and preliminary efficacy of Sirona, a novel gastro‐retentive, dual‐network polymer for weight management. Methods This pilot trial comprised a randomized, parallel‐group, double‐blind, placebo‐controlled (3:1 ratio), 12‐week period, with a 12‐week open‐label extension (OLE), in ...
James P. Byrne, Elanor C. Hinton, Asif Malik Humayun, Dimitri J. Pournaras, Rebecca L. Elsworth, Jeffrey M. Brunstrom, Julian P. Hamilton‐Shield, Mark Sumeray, Camilla Easter, Hutan Ashrafian   +9 more
wiley   +1 more source

Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management

Therapeutics and Clinical Risk Management, 2013
Wei Li,1 Su Zeng,2 Lu-Shan Yu,2 Quan Zhou31Division of Medical Affairs, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Pharmaceutical Analysis and Drug Metabolism, College ...
Li W, Zeng S, Yu LS, Zhou Q
doaj  

Complete Response of Severe, Refractory, Gastric, Stomal and Sclerotherapy-Induced Esophageal Ulcer Disease to Omeprazole Therapy

Canadian Journal of Gastroenterology, 1989
This report presents three unusual forms of resistant peptic ulcer disease, all healed completely with the use of a new class of anti-ulcer drug, a proton pump blocker, omeprazole. Each of these patients represents an unusual facet of acid-pepsin disease,
Earl P. Morgan, C.N. Williams
doaj   +1 more source

Effect of co-administered inducer or inhibitor on omeprazole pharmacokinetics based on CYP2C19 genotype

Journal of Pharmacological Sciences, 2019
Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug metabolism and drug interactions. Although the potential for drug interactions is especially important when co-administering drugs with strong inductive or inhibitory ...
Chiaki Kamiya, Naoki Inui, Akio Hakamata, Sachiko Miyakawa, Shimako Tanaka, Shinya Uchida, Noriyuki Namiki, Keiichi Odagiri, Hiroshi Watanabe   +8 more
doaj   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Advances in Factors and Risk Prediction of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt

Portal Hypertension &Cirrhosis, EarlyView.
Hepatic encephalopathy (HE) is a frequent complication that arises subsequent to transjugular intrahepatic portosystemic shunt (TIPS) procedures, with a considerable impact on patient prognosis. The occurrence of HE is influenced by multiple factors, and various risk prediction models have been developed in recent years to forecast its development post‐
Lixin Song, Xinyi Qiao, Yu Sun, Hui Yang
wiley   +1 more source

Assessing Safety Concerns in Omeprazole Use: An Observational Study of Potentially Inappropriate Prescriptions and Patient Adherence in a Spanish Community Pharmacy

Scientia Pharmaceutica
Introduction: Omeprazole is commonly prescribed for conditions associated with excess gastric acid, including gastroesophageal reflux and Helicobacter pylori infection.
Franc Capdevila Finestres, Daida Alberto Armas, Antoni Miró Manzano, Verónica Hernández García, Yeray Sosa Alonso, Arturo Hardisson de la Torre, Carmen Rubio Armendáriz   +6 more
doaj   +1 more source

A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Benefits of Using Lactobacillus Supplements as an Adjunct Treatment for Helicobacter pylori Eradication. [PDF]

Microbiologyopen
Lactobacillus supplementation, when used alongside triple or quadruple antibiotic therapy, significantly improved Helicobacter pylori eradication rates compared to placebo. Although reductions in adverse events and gastrointestinal symptoms were not statistically significant, strain variability limits conclusions regarding the specific efficacy of ...
Azam A, Qureshi MAM, Zahoor HS, Raza SM, Khan MM, Naeem U, Atif S, Waheed A.   +7 more
europepmc   +2 more sources

Acute hepatitis and haemolysis associated with doxycycline and rifampin administration in two weanling foals

Equine Veterinary Education, EarlyView.
Summary Two foals were being treated with a combination of oral doxycycline and rifampin for presumed Rhodococcus equi infections. After 3–4 weeks of antimicrobial administration, both foals presented with icterus and nonspecific clinical signs, including lethargy and inappetence.
A. Murdock, D. Wong, T. Hall, B. Sponseller, J. Howard, K. Frerichs, A. Bianco, R. Ruby   +7 more
wiley   +1 more source

Acid-Neutralizing Omeprazole Formulation for Rapid Release and Absorption

Pharmaceutics
Background/Objectives: Omeprazole undergoes degradation in acidic conditions, which makes it unstable in low pHs found in the gastric environment. The vast majority of already marketed omeprazole formulations use enteric polymer coatings to protect the ...
Sreela Ramesh, Vít Zvoníček, Daniel Pěček, Markéta Pišlová, Josef Beránek, Jiří Hofmann, Aleksandra Dumicic   +6 more
doaj   +1 more source