Results 61 to 70 of about 31,479 (242)

A simple isothermal DNA amplification method to screen black flies for Onchocerca volvulus infection. [PDF]

PLoS ONE, 2014
Onchocerciasis is a debilitating neglected tropical disease caused by infection with the filarial parasite Onchocerca volvulus. Adult worms live in subcutaneous tissues and produce large numbers of microfilariae that migrate to the skin and eyes.
Andy Alhassan, Benjamin L Makepeace, Elwyn James LaCourse, Mike Y Osei-Atweneboana, Clotilde K S Carlow   +4 more
doaj   +1 more source

Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.

PLoS Neglected Tropical Diseases, 2015
Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis.
Christina A Bulman, Chelsea M Bidlow, Sara Lustigman, Fidelis Cho-Ngwa, David Williams, Alberto A Rascón, Nancy Tricoche, Moses Samje, Aaron Bell, Brian Suzuki, K C Lim, Nonglak Supakorndej, Prasit Supakorndej, Alan R Wolfe, Giselle M Knudsen, Steven Chen, Chris Wilson, Kean-Hooi Ang, Michelle Arkin, Jiri Gut, Chris Franklin, Chris Marcellino, James H McKerrow, Anjan Debnath, Judy A Sakanari   +24 more
doaj   +1 more source

Evidence against Wolbachia symbiosis in Loa loa [PDF]

, 2003
BACKGROUND: The majority of filarial nematode species are host to Wolbachia bacterial endosymbionts, although a few including Acanthocheilonema viteae, Onchocerca flexuosa and Setaria equina have been shown to be free of infection. Comparisons of species
Akue, Jean-Paul, Beeching, Nick J, Bianco, Albert E, Egerton, Gill, Enyong, Peter, Hoerauf, Achim, Kläger, Sabine L, McGarry, Helen F, Pfarr, Ken, Taylor, Mark J, Wanji, Samuel   +10 more
core   +2 more sources

Evidence of suppression of onchocerciasis transmission in the Venezuelan Amazonian focus. [PDF]

, 2016
BACKGROUND: The World Health Organization (WHO) has set goals for onchocerciasis elimination in Latin America by 2015. Most of the six previously endemic countries are attaining this goal by implementing twice a year (and in some foci, quarterly) mass ...
Basanez, MG, Borges, D, Botto, C, Camacho, O, Coronel, P, Cortez, J, Escalona, M, Flores, J, Frontado, H, Graterol, B, Grillet, ME, Guerra, F, Margeli, H, Morales, AL, Noya-Alarcón, O, Rodriguez, MA, Ríos, D, Tovar, Y, Unnasch, TR, Villamizar, NJ, Vivas-Martínez, S   +20 more
core   +2 more sources

Extracellular Onchocerca-derived small RNAs in host nodules and blood

Parasites & Vectors, 2015
Background microRNAs (miRNAs), a class of short, non-coding RNA can be found in a highly stable, cell-free form in mammalian body fluids. Specific miRNAs are secreted by parasitic nematodes in exosomes and have been detected in the serum of murine and ...
Juan F Quintana, Benjamin L Makepeace, Simon A Babayan, Alasdair Ivens, Kenneth M Pfarr, Mark Blaxter, Alexander Debrah, Samuel Wanji, Henrietta F Ngangyung, Germanus S Bah, Vincent N Tanya, David W Taylor, Achim Hoerauf, Amy H Buck   +13 more
doaj   +1 more source

Recombinant expression systems: the obstacle to helminth vaccines? [PDF]

, 2007
A
Claerebout, Edwin, De Maere, Veerle, Geldhof, Peter, Vercruysse, Jozef   +3 more
core   +2 more sources

Elimination of onchocerciasis in Ecuador: findings of post-treatment surveillance. [PDF]

, 2018
BACKGROUND: The Esmeraldas focus of onchocerciasis in Ecuador expanded geographically during the 1980s and was associated with severe ocular and skin disease.
AG Guevara, AJ Shelley, AJ Shelley, AJ Shelley, B Thylefors, CR Katholi, EW Cupp, EW Cupp, HL Carvajal, JC Vieira, M Arzube, M Charalambous, M Charalambous, MA Rodríguez-Pérez, Mario A. Rodriguez-Perez, MG Basanez, Philip J. Cooper, PJ Cooper, PJ Cooper, R Lovato, Raquel Lovato, RC Collins, RC Collins, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RH Guderian, RJ Hay, Roberto Proaño, Ronald H. Guderian, S Wetten, Thomas Unnasch, WHO, WS Procunier, WS Procunier, Ángel Guevara   +38 more
core   +1 more source

Simuliidae and the transmission and control of human Onchocerciasis in Latin America

Cadernos de Saúde Pública, 1991
Factors that affect the propensity of a simuliid species to act as a host to Onchocerca volvulus and to naturally transmit this filarial worm in nature are discussed.
A. J. Shelley
doaj   +1 more source

Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. [PDF]

, 2002
BACKGROUND: The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS.
Andrew, R, Brunner, EJ, Checkley, S, Clarke, P, Hemingway, H, Juneja, M, Kumari, M, Lowe, GDO, Marmot, MG, Page, M, Papadopoulos, A, Rumley, A, Seckl, JR, Shipley, MJ, Stansfeld, SA, Walker, BR   +15 more
core   +1 more source

Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi

Frontiers in Cellular and Infection Microbiology, 2022
Human onchocerciasis is a devastating neglected tropical disease caused by infection of the filarial nematode Onchocerca volvulus. The infection can cause irreversible visual impairment or blindness and stigmatizing dermatitis.
Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Sara Lustigman   +3 more
doaj   +1 more source