Results 51 to 60 of about 14,649 (169)

Of mice, cattle, and humans: the immunology and treatment of river blindness.

PLoS Neglected Tropical Diseases, 2008
River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite
Judith E Allen, Ohene Adjei, Odile Bain, Achim Hoerauf, Wolfgang H Hoffmann, Benjamin L Makepeace, Hartwig Schulz-Key, Vincent N Tanya, Alexander J Trees, Samuel Wanji, David W Taylor   +10 more
doaj   +1 more source

The Mbam drainage system and onchocerciasis transmission post ivermectin mass drug administration (MDA) campaign, Cameroon.

PLoS Neglected Tropical Diseases, 2021
BackgroundThe impact of large scale Mass Drug Adminstration (MDA) of ivermectin on active onchocerciasis transmission by Simulium damnosum, which transmits the parasite O. volvulus is of great importance for onchocerciasis control programmes.
Raphael Awah Abong, Glory Ngongeh Amambo, Ali Ahamat Hamid, Belinda Agbor Enow, Amuam Andrew Beng, Franck Noel Nietcho, Theobald Mue Nji, Abdel Jelil Njouendou, Manuel Ritter, Mathias Eyong Esum, Kebede Deribe, Jerome Fru Cho, Fanny Fri Fombad, Peter Ivo Enyong, Catherine Poole, Kenneth Pfarr, Achim Hoerauf, Clotilde Carlow, Samuel Wanji   +18 more
doaj   +1 more source

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel, Philipp Wissel, Matthias Rischer, Felix Häberlein, Hilde Riethmüller‐Winzen, Hanns Häberlein   +5 more
wiley   +1 more source

Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo

Parasite Epidemiology and Control, 2018
Background: Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with ...
Francois Korbmacher, Kossi Komlan, Richard G. Gantin, Wiyao P. Poutouli, Koffi Padjoudoum, Potchoziou Karabou, Peter T. Soboslay, Carsten Köhler   +7 more
doaj   +1 more source

Intestinal Parasites of Zoonotic Significance in Human and Domestic Animals in a Rural Setting in Nepal

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Intestinal parasites are shared among humans and domestic animals. Rural setting is critical to enhance parasite zoonosis in Nepal. ABSTRACT Intestinal parasitic (IP) species with zoonotic significance are major public health issues, mostly prevalent in developing countries, leading to high morbidity and mortality. The present study aimed to assess the
Prince Rai, Tirth Raj Ghimire
wiley   +1 more source

Research for new drugs for elimination of onchocerciasis in Africa

International Journal for Parasitology: Drugs and Drug Resistance, 2016
Onchocerciasis is a parasitic, vector borne disease caused by the filarial nematode Onchocerca volvulus. More than 99% of the population at risk of infection live in Africa. Onchocerciasis control was initiated in West Africa in 1974 with vector control,
Annette C. Kuesel
doaj   +1 more source

Nodding syndrome research revisited

International Journal of Infectious Diseases, 2021
Nodding syndrome is one of several forms of onchocerciasis-associated epilepsy (OAE) seen among children in areas formerly hyperendemic for the transmission of Onchocerca volvulus.
Melissa Krizia Vieri, Adam Hendy, John L. Mokili, Robert Colebunders   +3 more
doaj   +1 more source

Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 continues to pose global challenges, and current vaccines face limitations (variant escape, waning immunity). This review evaluates immunostimulatory adjuvants and nano‐adjuvants to enhance immune responses and optimize SARS‐CoV‐2 vaccine performance.
Peyman Kheirandish Zarandi, Mohammad Reza Zinatizadeh, Mohsen Ghiasi, Mohammad Rezaei Zadeh Rukerd, Hanieh Mirkamali, Ehsan Shokri   +5 more
wiley   +1 more source

Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?

Ecology and Evolution, Volume 15, Issue 8, August 2025.
The nematode microbiota can influence life‐history traits, thereby shaping the species' ecology and evolutionary trajectories. ABSTRACT In recent decades, the microbiota has emerged as a key driver of biological functions in metazoans, and nematodes are no exception.
Víctor José Trejo‐Meléndez, Jorge Contreras‐Garduño   +1 more
wiley   +1 more source

An 18S ribosomal DNA barcode for the study of Isomermis lairdi, a parasite of the blackfly Simulium damnosum s.l.

, 2009
The mermithid parasite, Isomermis lairdi Mondet, Poinar & Bernadou (Nematoda: Mermithidae), is known to have a major impact on populations of Simulium damnosum s.l. Theobald (Diptera: Simuliidae) and on their efficiency as vectors of Onchocerca volvulus (
M. D. WILSON, R. J. POST, Post, RJ, Crainey, JL, Wilson, MD, J. L. CRAINEY   +5 more
core   +1 more source