Results 31 to 40 of about 6,880 (180)

Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits macrofilaricidal activity and holds promise to shorten treatment durations.
Frauke Assmus, Ayorinde Adehin, Richard M. Hoglund, Gloria Nyaulingo, Hussein Mbarak, Said Jongo, Eveline Ackermann, Elisabeth Reus, Jennifer Keiser, Fabiana Barreira Da Silva Rocha, Sabine Specht, Ivan Scandale, Joel Tarning   +12 more
wiley   +1 more source

Onchocerciasis control: biological research is still needed

Parasite, 2008
Achievements obtained by the onchocerciasis control programmes should not lead to a relaxation in the biological research on Onchocerca volvulus. Issues such as the Loa loa-related postivermectin serious adverse events, the uncertainties as to whether ...
Boussinesq M.
doaj   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, Volume 73, Issue 1, Page 95-106, February 2026.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel, Philipp Wissel, Matthias Rischer, Felix Häberlein, Hilde Riethmüller‐Winzen, Hanns Häberlein   +5 more
wiley   +1 more source

Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa.

PLoS Neglected Tropical Diseases, 2014
BackgroundEpilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE ...
Gathoni Kamuyu, Christian Bottomley, James Mageto, Brett Lowe, Patricia P Wilkins, John C Noh, Thomas B Nutman, Anthony K Ngugi, Rachael Odhiambo, Ryan G Wagner, Angelina Kakooza-Mwesige, Seth Owusu-Agyei, Kenneth Ae-Ngibise, Honorati Masanja, Faith H A Osier, Peter Odermatt, Charles R Newton, Study of Epidemiology of Epilepsy in Demographic Sites (SEEDS) group   +17 more
doaj   +1 more source

Viability of Onchocerca volvulus in vitro

Parasitology, 1993
SUMMARYThe use of a selective schedule of tests to identify a viable population of isolated adult Onchocerca volvulus (Nematoda: Filarioidea) has been investigated in a large worm population. The study was initiated to develop methodology appropriate to test new candidate macrofilaricides for their in vitro activity against O. volvulus.
G, Strote, A, Bokhof, J C, Comley
openaire   +2 more sources

Intestinal Parasites of Zoonotic Significance in Human and Domestic Animals in a Rural Setting in Nepal

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Intestinal parasites are shared among humans and domestic animals. Rural setting is critical to enhance parasite zoonosis in Nepal. ABSTRACT Intestinal parasitic (IP) species with zoonotic significance are major public health issues, mostly prevalent in developing countries, leading to high morbidity and mortality. The present study aimed to assess the
Prince Rai, Tirth Raj Ghimire
wiley   +1 more source

Spatial and temporal diversity of Simulium damnosum s.l. gut microbiota and association with Onchocerca volvulus infection in Cameroon

International Journal of Infectious Diseases
Introduction: The arthropod microbiota plays a crucial role in host physiology, from the complementation of certain metabolic pathways to the bioecological adaptation of vectors.
Mr Arnauld Ekangouo, Dr Hugues Nana-Djeunga, Dr Philippe Nwane, Dr Guilhem Sempere, Prof Joseph Kamgno, Dr Anne Gieger   +5 more
doaj   +1 more source

The mitogenome of Onchocerca volvulus from the Brazilian Amazonia focus

Memorias do Instituto Oswaldo Cruz, 2016
We report here the first complete mitochondria genome of Onchocerca volvulus from a focus outside of Africa. An O. volvulus mitogenome from the Brazilian Amazonia focus was obtained using a combination of high-throughput and Sanger sequencing ...
James L Crainey, Túllio RR da Silva, Fernando Encinas, Michel A Marín, Ana Carolina P Vicente, Sérgio LB Luz   +5 more
doaj   +1 more source

Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 continues to pose global challenges, and current vaccines face limitations (variant escape, waning immunity). This review evaluates immunostimulatory adjuvants and nano‐adjuvants to enhance immune responses and optimize SARS‐CoV‐2 vaccine performance.
Peyman Kheirandish Zarandi, Mohammad Reza Zinatizadeh, Mohsen Ghiasi, Mohammad Rezaei Zadeh Rukerd, Hanieh Mirkamali, Ehsan Shokri   +5 more
wiley   +1 more source