Results 21 to 30 of about 6,899 (180)

Extracellular Onchocerca-derived small RNAs in host nodules and blood

Parasites & Vectors, 2015
Background microRNAs (miRNAs), a class of short, non-coding RNA can be found in a highly stable, cell-free form in mammalian body fluids. Specific miRNAs are secreted by parasitic nematodes in exosomes and have been detected in the serum of murine and ...
Juan F Quintana, Benjamin L Makepeace, Simon A Babayan, Alasdair Ivens, Kenneth M Pfarr, Mark Blaxter, Alexander Debrah, Samuel Wanji, Henrietta F Ngangyung, Germanus S Bah, Vincent N Tanya, David W Taylor, Achim Hoerauf, Amy H Buck   +13 more
doaj   +1 more source

Epilepsy in Onchocerca volvulus Sero-Positive Patients From Northern Uganda—Clinical, EEG and Brain Imaging Features

Frontiers in Neurology, 2021
Globally, epilepsy is the most common chronic neurological disorder. The incidence in sub-Saharan Africa is 2-3 times higher than that in high income countries.
Rodney Ogwang, Rodney Ogwang, Rodney Ogwang, Albert Ningwa, Albert Ningwa, Pamela Akun, Pamela Akun, Paul Bangirana, Ronald Anguzu, Ronald Anguzu, Ronald Anguzu, Rajarshi Mazumder, Noriko Salamon, Oliver Johannes Henning, Charles R. Newton, Charles R. Newton, Catherine Abbo, Amos Deogratius Mwaka, Kevin Marsh, Richard Idro, Richard Idro, Richard Idro   +21 more
doaj   +1 more source

Simuliidae and the transmission and control of human Onchocerciasis in Latin America

Cadernos de Saúde Pública, 1991
Factors that affect the propensity of a simuliid species to act as a host to Onchocerca volvulus and to naturally transmit this filarial worm in nature are discussed.
A. J. Shelley
doaj   +1 more source

Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi

Frontiers in Cellular and Infection Microbiology, 2022
Human onchocerciasis is a devastating neglected tropical disease caused by infection of the filarial nematode Onchocerca volvulus. The infection can cause irreversible visual impairment or blindness and stigmatizing dermatitis.
Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Sara Lustigman   +3 more
doaj   +1 more source

Prevalence and risk factors for Active Convulsive Epilepsy in Kintampo, Ghana

The Pan African Medical Journal, 2015
INTRODUCTION: epilepsy is common in sub-Saharan Africa, but there is little data in West Africa, to develop public health measures for epilepsy in this region.
Kenneth Ayuurebobi Ae-Ngibise, Bright Akpalu, Anthony Ngugi, Albert Akpalu, Francis Agbokey, Patrick Adjei, Damien Punguyire, Christian Bottomley, Charles Newton, Seth Owusu-Agyei   +9 more
doaj   +1 more source

The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca volvulus Excretory Secretory Products

Pathogens, 2020
Nematodes constitute a very successful phylum, especially in terms of parasitism. Inside their mammalian hosts, parasitic nematodes mainly dwell in the digestive tract (geohelminths) or in the vascular system (filariae). One of their main characteristics
Luc Vanhamme, Jacob Souopgui, Stephen Ghogomu, Ferdinand Ngale Njume   +3 more
doaj   +1 more source

Unraveling cross-reactivity of anti-glycan IgG responses in filarial nematode infections

Frontiers in Immunology, 2023
Parasitic nematodes responsible for filarial diseases cause chronic disablement in humans worldwide. Elimination programs have substantially reduced the rate of infection in certain areas, but limitations of current diagnostics for population ...
Laudine M. C. Petralia, Laudine M. C. Petralia, Angela van Diepen, Dieu-Linh Nguyen, Lena A. Lokker, Erliyani Sartono, Sasisekhar Bennuru, Thomas B. Nutman, Kenneth Pfarr, Kenneth Pfarr, Achim Hoerauf, Achim Hoerauf, Samuel Wanji, Jeremy M. Foster, Cornelis H. Hokke   +14 more
doaj   +1 more source

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

Acta Crystallographica Section F, Volume 82, Issue 6, Page 194-200, June 2026.
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair, Matthew Lin, Arav Srivastava, Lijun Liu, Anne Cooper, Kevin Battaile, Elizabeth Harmon, Peter J. Myler, Bart L. Staker, Scott Lovell, Graham Chakafana, Oluwatoyin A. Asojo   +11 more
wiley   +1 more source

Evolution of Ivermectin Resistance in the Nematode Model Caenorhabditis elegans: Critical Influence of Population Size and Altered Emodepside Efficacy

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT The emergence and spread of anthelmintic resistance represent a major challenge for treating parasitic nematodes, threatening mass‐drug administration control programs in humans and zoonotic hosts. Currently, experimental evidence to understand the influence of management (e.g., treatment dose and frequency) and parasite‐associated factors (e ...
Jacqueline Hellinga, Barbora Trubenova, Jessica Wagner, Marc Borchert, Jürgen Krücken, Roland R. Regoes, Hinrich Schulenburg, Georg von Samson‐Himmelstjerna   +7 more
wiley   +1 more source

Helminths as architects of trained tolerance: implications for human health

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Abstract Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low‐resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years‐long persistence and reinfection.
Quinn Moroz, Jorge Lucas Nascimento Souza, Neima Briggs   +2 more
wiley   +1 more source