Results 71 to 80 of about 31,479 (242)

Factors affecting onchocerciasis transmission: Lessons for infection control [PDF]

, 2017
Introduction: Onchocerca volvulus infects in excess of 15 million people. The vectors are Simulium blackflies, varieties of which differ in their ecologies, behaviour and vectorial abilities.
Cheke, Robert A.
core   +1 more source

Potential value of triple drug therapy with ivermectin, diethylcarbamazine, and albendazole (IDA) to accelerate elimination of lymphatic filariasis and onchocerciasis in Africa [PDF]

, 2017
<p>Background: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the
Fischer, Peter U, Jacobson, Julie A, King, Christopher L, Weil, Gary J   +3 more
core   +13 more sources

Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms

PLoS Neglected Tropical Diseases, 2019
Background The human filarial parasite Onchocerca volvulus is the causative agent of onchocerciasis (river blindness). It causes blindness in 270,000 individuals with an additional 6.5 million suffering from severe skin pathologies. Current international
D. Voronin, Nancy Tricoche, Shabnam Jawahar, Michael Shlossman, Christina A. Bulman, Chelsea Fischer, M. T. Suderman, J. Sakanari, S. Lustigman   +8 more
semanticscholar   +1 more source

Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal [PDF]

, 2017
The onchocerciasis transmission models EPIONCHO and ONCHOSIM have been independently developed and used to explore the feasibility of eliminating onchocerciasis from Africa with mass (annual or biannual) distribution of ivermectin within the timeframes ...
Basáñez, M-G, Bottomley, C, De Vlas, S J, Diawara, L, Dixon, M A, Stolk, W A, Traoré, M O, Walker, M   +7 more
core   +7 more sources

Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans

PLoS Neglected Tropical Diseases, 2019
Background The current strategy for the elimination of onchocerciasis is based on annual or bi-annual mass drug administration with ivermectin. However, due to several limiting factors there is a growing concern that elimination of onchocerciasis cannot ...
J. P, Jessica A. Hess, Sonia Jain, J. Patton, Tingting Zhan, Nancy Tricoche, B. Zhan, M. Bottazzi, P. Hotez, D. Abraham, S. Lustigman   +10 more
semanticscholar   +1 more source

PD‐L2 Inhibits Protective Immunity, Th2 Cell Functional Quality, and GATA‐3 Expression During Filarial Nematode Infection

European Journal of Immunology, Volume 55, Issue 8, August 2025.
During filarial nematode infection with Litomosoides sigmodontis, PD‐L2 down‐regulates Th2 cell expression of GATA‐3 and Th2 cytokines and enables parasite survival. Concurrently, B cells suppress protective immunity through a mechanism that does not involve PD‐L2.
Johanna A. Knipper, Sharon M. Campbell, Judith E. Allen, Matthew D. Taylor   +3 more
wiley   +1 more source

The Population Biology and Transmission Dynamics of Loa loa [PDF]

, 2017
Endemic to Central Africa, loiasis – or African eye worm (caused by the filarial nematode Loa loa) – affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of public ...
Basáñez, M-G, Boussinesq, M, Chesnais, C B, Pion, S D S, Walker, M, Whittaker, C   +5 more
core   +1 more source

Identification and characterization of the Onchocerca volvulus Excretory Secretory Product Ov28CRP, a putative GM2 activator protein

PLoS Neglected Tropical Diseases, 2019
Onchocerca volvulus is the nematode pathogen responsible for human onchocerciasis also known as “River blindness”, a neglected tropical disease that affects up to 18 million people worldwide.
F. Njume, S. Ghogomu, R. A. Shey, L. T. Gainkam, P. Poelvoorde, P. Humblet, J. Kamgno, A. Robert, L. Mutesa, C. Lelubre, E. Edelweiss, A. Poterszman, Susi Anheuser, L. Vanhamme, J. Souopgui   +14 more
semanticscholar   +1 more source

The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review

Health Science Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background and Aims Rwanda is among the African countries affected by neglected tropical diseases (NTDs). This scoping review aims to synthesize available information to understand the prevalence, incidence, distribution, morbidity, mortality, and risk factors of NTDs in Rwanda.
Masceline Jenipher Mutsaka‐Makuvaza, Michael Olubusayo Binuyo, Callixte Cyuzuzo, Acsa Igizeneza, Jean Paul Sinumvayo, Oluwaremilekun Grace Ajakaye, Egie Elisha Enabulele, Zororo Chinwadzimba, Ezera Agwu, Nicholas Midzi   +9 more
wiley   +1 more source

Onchocerciasis control: biological research is still needed

Parasite, 2008
Achievements obtained by the onchocerciasis control programmes should not lead to a relaxation in the biological research on Onchocerca volvulus. Issues such as the Loa loa-related postivermectin serious adverse events, the uncertainties as to whether ...
Boussinesq M.
doaj   +1 more source