Results 41 to 50 of about 11,845 (228)

Spatial clustering of onchocerciasis in Bioko Island, Equatorial Guinea

Journal of Infection in Developing Countries, 2018
Introduction: Onchocerciasis is a chronic neglected tropical disease caused by the filarial nematode Onchocerca volvulus, which is endemic in Equatorial Guinea.
Diana Gómez-Barroso, Laura Moya, Zaida Herrador, Belén García, Justino Nguema, Policarpo Ncogo, Pilar Aparicio, Agustín Benito   +7 more
doaj   +1 more source

Persistence of onchocerciasis in villages in Enugu and Ogun states in Nigeria following many rounds of mass distribution of ivermectin [PDF]

, 2022
Uwem Friday Ekpo, Obiora A. Eneanya, Edith N. Nwankwo, Islamiat Y. Soneye, Gary J. Weil, Peter Fischer, Obioma C. Nwaorgu   +6 more
openalex   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, Volume 73, Issue 1, Page 95-106, February 2026.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel, Philipp Wissel, Matthias Rischer, Felix Häberlein, Hilde Riethmüller‐Winzen, Hanns Häberlein   +5 more
wiley   +1 more source

Hidden in Plain Sight: The Enduring Challenge of Neglected Tropical Diseases in Khartoum State, Sudan

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Background Neglected tropical diseases (NTDs) disproportionately affect impoverished populations in tropical regions. Despite their significant health burden, data on NTD prevalence and distribution are limited in many areas, including Khartoum State, Sudan.
Babiker Mohamed Rahamtalla, Max Carlos Ramirez-Soto   +1 more
wiley   +1 more source

Neutrophil Extracellular Traps in Wound Healing of Diabetes: Mechanisms, Inducers, and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Wound healing damage, especially diabetic foot ulcer (DFU), is a serious complication of diabetes mellitus (DM). New evidence shows that neutrophil extracellular traps (NETs) are the key factor of this pathology. This review summarizes the literature from 2015 to 2024 to clarify the mechanism of NETs and its harmful effects on diabetes wounds.
Jiaojiao Xue, Zeyu Wang, Wenxiu Qi, Yao Luo   +3 more
wiley   +1 more source

An appraisal of the neglected tropical diseases control program in Cameroon: the case of the national program against onchocerciasis

BMC Public Health, 2017
Background Onchocerciasis is a severe parasitic infestation which causes disabling skin and subcutaneous tissue changes. Current global estimates suggest that it accounts for 1135.7 disability adjusted life years (DALYs) per 100,000 population.
Tsi Njim, Leopold Ndemnge Aminde
doaj   +1 more source

Risk Factors and Genetics of Dementia in Africa

Alzheimer's &Dementia, Volume 21, Issue S6, December 2025.
Abstract Background The burden of dementia in Africa is projected to grow exponentially by the year 2050 driven by population growth, population ageing and other factors. There is an heterogenous body of knowledge on modifiable risk factors but limited understanding of the genetic architecture of dementia in Africa.
Rufus O. Akinyemi
wiley   +1 more source

Assessment of community’s knowledge, attitude and practice about onchocerciasis and community directed treatment with Ivermectin in Quara District, north western Ethiopia

Parasites & Vectors, 2014
Background The African Program for Onchocerciasis Control (APOC) has been working with ultimate goal of reducing the public health and socio-economic problems associated with onchocerciasis within a period of 12–15 years.
Fitsum Weldegebreal, Girmay Medhin, Zemichael Weldegebriel, Mengistu Legesse   +3 more
doaj   +1 more source

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source