Results 41 to 50 of about 18,365 (214)

Ivermectin for onchocercal eye disease (river blindness).

, 2012
BACKGROUND: It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are ...
Ejere, Henry OD, Evans, Jennifer R, Schwartz, Ellen, Wormald, Richard   +3 more
core   +1 more source

Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with Schistosomiasis Control Initiative-assisted programmes [PDF]

, 2015
The last decade has seen an expansion of national schistosomiasis control programmes in Africa based on large-scale preventative chemotherapy. In many areas this has resulted in considerable reductions in infection and morbidity levels in treated ...
A Garba, AD Barbour, AD Barbour, AJ Fulford, AJ Fulford, Alan Fenwick, Amadou Garba, AP Plaisier, AP Plaisier, ARC Harris, AW Cheever, B Bolker, B Payet, BL Webster, BL Webster, BL Webster, BR Kirkwood, CH King, CH King, D Engels, D Gurarie, DL Smith, E Michael, E Miguel, EK N'Goran, Elisa Bosqué-Oliva, Fiona M. Fleming, G Webbe, GA Macdonald, GE Box, GF Medley, H Laamrani, H Tanaka, Hairston NG, HC Turner, HC Turner, HP Duerr, I Nåsell, I Nåsell, J Utzinger, J Utzinger, James Mwansa, JH Ouma, Joanne P. Webster, JP Webster, JW Rudge, JW Rudge, L Van Etten, LA Tchuem-Tchuenté, LA Tchuem-Tchuenté, Lynsey Blair, M Booth, M Parker, M Tanner, M-G Basáñez, M-G Basáñez, Maria-Gloria Basáñez, ME Woolhouse, Michael D. French, ML Steinauer, Moussa Sacko, MS Chan, MS Chan, MS Chan, N Katz, Narcis B. Kabatereine, NB Kabatereine, NG Hairston, RM Anderson, RM Anderson, RM Anderson, RM Anderson, RM May, Seydou Toure, SJ de Vlas, SM Blower, Team" RDC, Thomas S. Churcher, Ursuline Nyandindi, WHO   +79 more
core   +4 more sources

Beyond birds: rethinking bird‐centered pathogen models in light of insect migration

Ecography, EarlyView.
Migration redistributes biomass, nutrients, and pathogens across ecosystems. For decades, migratory birds have been treated as the default long‐distance pathogen vectors, shaping both conceptual frameworks and empirical models of disease ecology.
Virginia Morandini
wiley   +1 more source

An 18S ribosomal DNA barcode for the study of Isomermis lairdi, a parasite of the blackfly Simulium damnosum s.l.

, 2009
The mermithid parasite, Isomermis lairdi Mondet, Poinar & Bernadou (Nematoda: Mermithidae), is known to have a major impact on populations of Simulium damnosum s.l. Theobald (Diptera: Simuliidae) and on their efficiency as vectors of Onchocerca volvulus (
Blaxter, Borsboom, Colbo, Crosskey, Crosskey, Davies, Finney, Floyd, Foottit, Holterman, Kaiser, Molloy, Molloy, Mondet, Mondet, Mondet, Osei-Atweneboana, Platzer, Poinar, Poinar, Post, Rubstov, St-Onge, Van Emden, Vandergast, Walsh, Wilson   +26 more
core   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Investigation of publication trends and hot topics on onchocerciasis between 2000 and 2022

Journal of Zoonotic Diseases, 2023
This study aimed to use bibliometric tools to investigate onchocerciasis research conducted worldwide between 2000 and 2022. This bibliometric study was carried out using the Scopus database.
Sevil Alkan, Esra Gürbüz, Selahattin Aydemir   +2 more
doaj   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Co-infection with Onchocerca volvulus and Loa loa microfilariae in central Cameroon: are these two species interacting? [PDF]

, 2006
Ivermectin treatment may induce severe adverse reactions in some individuals heavily infected with Loa loa. This hampers the implementation of mass ivermectin treatment against onchocerciasis in areas where Onchocerca volvulus and L.
Basáñez, M-G, Boussinesq, M, Clarke, P, Filipe, JAN, Gardon, J, Kamgno, J, Pion, SDS   +6 more
core   +1 more source

Dipteran succession on decomposing domestic pig carcasses in a rural area of southeastern Brazil

Scientific Reports
Diptera plays a pivotal role in forensic investigations, particularly in estimating the post-mortem interval. This can be achieved by analyzing the succession patterns of species on decomposing bodies, which requires detailed knowledge of the local fauna.
Carlos Henrique Garção-Neto, Lucas Barbosa Cortinhas, Paloma Martins Mendonça, Marina Lopes Duarte, Renato Tavares Martins, Margareth Maria de Carvalho Queiroz   +5 more
doaj   +1 more source

Advancing Pharmacoequity in Low‐ and Middle‐Income Countries via Model Informed Drug Development

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Across low‐ and middle‐income countries (LMICs) inequities in access to safe, effective medicines persist due to limited regulatory capacity, inadequate financing, and insufficient local data. Regulatory authorities are engaging with model‐informed drug development (MIDD), but uneven technical readiness and resource gaps limit uptake ...
Henry Enzama, Francis Williams Ojara, Ian S. Haworth, Sandra Cvijic, Catriona Waitt, Thaddeus H. Grasela   +5 more
wiley   +1 more source