Results 41 to 50 of about 8,184 (177)

In Silico Design and Computational Characterization of Novel Chimeric Multiepitope Antigens for Mpox Serosurveillance: An Immunoinformatics Approach

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims The Monkeypox (Mpox) virus is a zoonotic Orthopoxvirus with a global outbreak that began in 2022, with more than 132,000 confirmed cases and 1500 deaths across over 128 countries. The pandemic preparedness pipeline emphasizes the importance of diagnostic surveillance of pathogens in at‐risk populations to monitor ...
Roland Ngwese Akwelle, Robert Adamu Shey, Mary Teke Efeti, Lekeayi Nelson Acha, Gordon Takop Nchanji, Yanick Aqua Stong Tangan, Joan Amban Chick, Ntang Emmaculate Yaah, Lahngong Methodius Shinyuy, Cabirou Mounchili Shintouo, Bernis Neneyoh Yengo, Abey Blessings Ayuk, Junior Ekunidi Engarimbi, Ketura Yaje Gwei, Brinate Teke Tebo, Derrick Neba Nebangwa, Beltine Muyer Tamnjong, Luc Vanhamme, Jacob Souopgui, Vincent P. K. Titanji, Stephen Mbigha Ghogomu   +20 more
wiley   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Advancing Pharmacoequity in Low‐ and Middle‐Income Countries via Model Informed Drug Development

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Across low‐ and middle‐income countries (LMICs) inequities in access to safe, effective medicines persist due to limited regulatory capacity, inadequate financing, and insufficient local data. Regulatory authorities are engaging with model‐informed drug development (MIDD), but uneven technical readiness and resource gaps limit uptake ...
Henry Enzama, Francis Williams Ojara, Ian S. Haworth, Sandra Cvijic, Catriona Waitt, Thaddeus H. Grasela   +5 more
wiley   +1 more source

The Potential of Bioinformatics in Revolutionizing Disease Diagnosis in Sub‐Saharan Africa: A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aim Despite its role in healthcare delivery and accessibility, the potential of bioinformatics to transform disease diagnosis in SSA remains unknown. This narrative review aims to assess the current status of bioinformatics initiatives in SSA and evaluate the role of bioinformatics in transforming diagnosis of major diseases in ...
Wilfred Ofosu, Fleischer C. N. Kotey, Alex Odoom, Onyansaniba K. Ntim, Eric S. Donkor   +4 more
wiley   +1 more source

An appraisal of the neglected tropical diseases control program in Cameroon: the case of the national program against onchocerciasis

BMC Public Health, 2017
Background Onchocerciasis is a severe parasitic infestation which causes disabling skin and subcutaneous tissue changes. Current global estimates suggest that it accounts for 1135.7 disability adjusted life years (DALYs) per 100,000 population.
Tsi Njim, Leopold Ndemnge Aminde
doaj   +1 more source

Evolution of Ivermectin Resistance in the Nematode Model Caenorhabditis elegans: Critical Influence of Population Size and Altered Emodepside Efficacy

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT The emergence and spread of anthelmintic resistance represent a major challenge for treating parasitic nematodes, threatening mass‐drug administration control programs in humans and zoonotic hosts. Currently, experimental evidence to understand the influence of management (e.g., treatment dose and frequency) and parasite‐associated factors (e ...
Jacqueline Hellinga, Barbora Trubenova, Jessica Wagner, Marc Borchert, Jürgen Krücken, Roland R. Regoes, Hinrich Schulenburg, Georg von Samson‐Himmelstjerna   +7 more
wiley   +1 more source

Assessment of community’s knowledge, attitude and practice about onchocerciasis and community directed treatment with Ivermectin in Quara District, north western Ethiopia

Parasites & Vectors, 2014
Background The African Program for Onchocerciasis Control (APOC) has been working with ultimate goal of reducing the public health and socio-economic problems associated with onchocerciasis within a period of 12–15 years.
Fitsum Weldegebreal, Girmay Medhin, Zemichael Weldegebriel, Mengistu Legesse   +3 more
doaj   +1 more source

From Aid Dependency to Self‐Reliance: Lessons From Sierra Leone and Rwanda's Strategies for Eliminating Preventable Blindness in Africa: A Perspective Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Preventable blindness remains a leading cause of disability in low‐income countries (LICs), with 91.5% of cases in Sierra Leone and 83.9% in Rwanda considered avoidable. Reliance on foreign aid has supported eye care development in Africa, yet has also fostered systemic dependency.
Babatunde Ismail Bale, Lynette Delali Amematekpor, Ebunoluwa Anne Ajibola‐Ajo, Seriki Yetunde Mutiat, Ojo Onakhe Emmanuel, Adeleke Oluwatimilehin   +5 more
wiley   +1 more source

Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits macrofilaricidal activity and holds promise to shorten treatment durations.
Frauke Assmus, Ayorinde Adehin, Richard M. Hoglund, Gloria Nyaulingo, Hussein Mbarak, Said Jongo, Eveline Ackermann, Elisabeth Reus, Jennifer Keiser, Fabiana Barreira Da Silva Rocha, Sabine Specht, Ivan Scandale, Joel Tarning   +12 more
wiley   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, Volume 73, Issue 1, Page 95-106, February 2026.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source