Results 51 to 60 of about 18,093 (248)

Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes

Infectious Diseases of Poverty, 2018
Background Onchocerciasis is found predominantly in Africa where large scale vector control started in 1974. Registration and donation of ivermectin by Merck & Co in 1987 enabled mass treatment with ivermectin in all endemic countries in Africa and the ...
Yankum Dadzie, Uche V. Amazigo, Boakye A. Boatin, Azodoga Sékétéli   +3 more
doaj   +1 more source

Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis

GMS Infectious Diseases, 2022
Filarial diseases like lymphatic filariasis and onchocerciasis belong to the Neglected Tropical Diseases and remain a public health problem in endemic countries.
Ehrens, Alexandra, Hoerauf, Achim, Hübner, Marc P.   +2 more
doaj   +1 more source

Burden of onchocerciasis-associated epilepsy: first estimates and research priorities

Infectious Diseases of Poverty, 2018
Background Since the 1990s, evidence has accumulated of an increased prevalence of epilepsy in onchocerciasis-endemic areas in Africa as compared to onchocerciasis-free areas.
Natalie V. S. Vinkeles Melchers, Sarah Mollenkopf, Robert Colebunders, Michael Edlinger, Luc E. Coffeng, Julia Irani, Trésor Zola, Joseph N. Siewe, Sake J. de Vlas, Andrea S. Winkler, Wilma A. Stolk   +10 more
doaj   +1 more source

What does the COVID-19 pandemic mean for the next decade of onchocerciasis control and elimination?

medRxiv, 2020
Background: Mass drug administration (MDA) of ivermectin for onchocerciasis has been disrupted by the SARS-CoV-2 (COVID-19) pandemic. Mathematical modelling can help predict how missed/delayed MDA will affect short-term epidemiological trends and ...
Jonathan I D Hamley, D. Blok, M. Walker, Philip Milton, A. Hopkins, L. Hamill, P. Downs, S. D. de Vlas, W. Stolk, M. Basáñez   +9 more
semanticscholar   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source

Investigation of publication trends and hot topics on onchocerciasis between 2000 and 2022

Journal of Zoonotic Diseases, 2023
This study aimed to use bibliometric tools to investigate onchocerciasis research conducted worldwide between 2000 and 2022. This bibliometric study was carried out using the Scopus database.
Sevil Alkan, Esra Gürbüz, Selahattin Aydemir   +2 more
doaj   +1 more source

The Interruption of Transmission of Human Onchocerciasis by an Annual Mass Drug Administration Program in Plateau and Nasarawa States, Nigeria

American Journal of Tropical Medicine and Hygiene, 2020
. Plateau and Nasarawa states in central Nigeria were endemic for onchocerciasis. The rural populations of these two states received annual ivermectin mass drug administration (MDA) for a period of 8–26 years (1992–2017).
F. Richards, A. Eigege, J. Umaru, Barminas Kahansim, Solomon E. Adelamo, Jonathan Kadimbo, J. Danboyi, H. Mafuyai, Y. Saka, Gregory S Noland, C. Anyaike, Michael A. Igbe, Lindsay J. Rakers, E. Griswold, T. Unnasch, B. E. Nwoke, E. Miri   +16 more
semanticscholar   +1 more source

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel, Philipp Wissel, Matthias Rischer, Felix Häberlein, Hilde Riethmüller‐Winzen, Hanns Häberlein   +5 more
wiley   +1 more source

The Galabat-Metema cross-border onchocerciasis focus: The first coordinated interruption of onchocerciasis transmission in Africa

PLoS Neglected Tropical Diseases, 2020
Background Onchocerciasis transmission across international borders is not uncommon, yet a coordinated cross border stops mass drug administration (MDA) decision has not been documented.
M. Katabarwa, Isam M. A. Zarroug, N. Negussu, Nabil Aziz, Z. Tadesse, Wigdan A Elmubark, Zainab Shumo, Kadu Meribo, Hashim Kamal, Aderajew Mohammed, Yewondwossen Bitew, Tewodros Seid, Firdaweke Bekele, A. Yilak, T. Endeshaw, Mohammed Hassen, Abate Tillahun, Fikresilasie Samuel, Henok Birhanu, Tadesse Asmare, D. Boakye, S. Feleke, T. Unnasch, R. Post, T. Higazi, E. Griswold, C. Mackenzie, F. Richards   +27 more
semanticscholar   +1 more source

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source