Results 61 to 70 of about 28,700 (244)

Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Cote d\u27Ivoire [PDF]

, 2019
BackgroundA single co-administered dose of ivermectin (IVM) plus diethylcarbamazine (DEC) plus albendazole (ALB), or triple-drug therapy, was recently found to be more effective for clearing microfilariae (Mf) than standard DEC plus ALB currently used ...
Bjerum, Catherine M, Chhonker, Yashpal S, Edi, Constant, King, Christopher L, Koudou, Benjamin G, Meite, Aboulaye, Murry, Daryl J, Ouattara, Allassane F, Penali, Louis K, Weil, Gary J   +9 more
core   +4 more sources

Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis

GMS Infectious Diseases, 2022
Filarial diseases like lymphatic filariasis and onchocerciasis belong to the Neglected Tropical Diseases and remain a public health problem in endemic countries.
Ehrens, Alexandra, Hoerauf, Achim, Hübner, Marc P.   +2 more
doaj   +1 more source

Burden of onchocerciasis-associated epilepsy: first estimates and research priorities

Infectious Diseases of Poverty, 2018
Background Since the 1990s, evidence has accumulated of an increased prevalence of epilepsy in onchocerciasis-endemic areas in Africa as compared to onchocerciasis-free areas.
Natalie V. S. Vinkeles Melchers, Sarah Mollenkopf, Robert Colebunders, Michael Edlinger, Luc E. Coffeng, Julia Irani, Trésor Zola, Joseph N. Siewe, Sake J. de Vlas, Andrea S. Winkler, Wilma A. Stolk   +10 more
doaj   +1 more source

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. [PDF]

, 2018
BACKGROUND: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection.
Abraham, David, Bennuru, Sasisekhar, Eberhard, Mark L., Hess Ligas, Jessica A., Lustigman, Sara, Nutman, Thomas B., Patton, John B., Torigian, April R.   +7 more
core   +3 more sources

Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes

Infectious Diseases of Poverty, 2018
Background Onchocerciasis is found predominantly in Africa where large scale vector control started in 1974. Registration and donation of ivermectin by Merck & Co in 1987 enabled mass treatment with ivermectin in all endemic countries in Africa and the ...
Yankum Dadzie, Uche V. Amazigo, Boakye A. Boatin, Azodoga Sékétéli   +3 more
doaj   +1 more source

An 18S ribosomal DNA barcode for the study of Isomermis lairdi, a parasite of the blackfly Simulium damnosum s.l.

, 2009
The mermithid parasite, Isomermis lairdi Mondet, Poinar & Bernadou (Nematoda: Mermithidae), is known to have a major impact on populations of Simulium damnosum s.l. Theobald (Diptera: Simuliidae) and on their efficiency as vectors of Onchocerca volvulus (
Blaxter, Borsboom, Colbo, Crosskey, Crosskey, Davies, Finney, Floyd, Foottit, Holterman, Kaiser, Molloy, Molloy, Mondet, Mondet, Mondet, Osei-Atweneboana, Platzer, Poinar, Poinar, Post, Rubstov, St-Onge, Van Emden, Vandergast, Walsh, Wilson   +26 more
core   +1 more source

An estimate of the prevalence of epilepsy in Sub-Saharan Africa:A systematic analysis [PDF]

, 2012
Epilepsy is a leading serious neurological condition worldwide and has particularly significant physical, economic and social consequences in Sub–Saharan Africa.
Adeloye, Davies, Chan, Kit Yee, George-Carey, Rhiannon, Grant, Elizabeth, Kolčić, Ivana, Paul, Abigail   +5 more
core   +2 more sources

What does the COVID-19 pandemic mean for the next decade of onchocerciasis control and elimination?

medRxiv, 2020
Background: Mass drug administration (MDA) of ivermectin for onchocerciasis has been disrupted by the SARS-CoV-2 (COVID-19) pandemic. Mathematical modelling can help predict how missed/delayed MDA will affect short-term epidemiological trends and ...
Jonathan I D Hamley, D. Blok, M. Walker, Philip Milton, A. Hopkins, L. Hamill, P. Downs, S. D. de Vlas, W. Stolk, M. Basáñez   +9 more
semanticscholar   +1 more source

Ivermectin for onchocercal eye disease (river blindness).

, 2012
BACKGROUND: It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are ...
Ejere, Henry OD, Evans, Jennifer R, Schwartz, Ellen, Wormald, Richard   +3 more
core   +1 more source

The application of predictive modelling for determining bio-environmental factors affecting the distribution of blackflies (Diptera: Simuliidae) in the Gilgel Gibe watershed in Southwest Ethiopia [PDF]

, 2014
Blackflies are important macroinvertebrate groups from a public health as well as ecological point of view. Determining the biological and environmental factors favouring or inhibiting the existence of blackflies could facilitate biomonitoring of rivers ...
A Ambelu, A Cheaib, A Guisan, A Guisan, A Palialexis, Arash Rashed, Argaw Ambelu, B Planque, E Dakou, EG Gibbins, Gert Everaert, IG Jowett, JL Reid, JR Quinlan, K Lock, M Giannoulaki, M Giannoulaki, MA Hall, Magaly Koch, MJ Taylor, MP Austin, N Kazanci, Peter Goethals, Pieter Boets, PLM Goethals, R Figueiró, R Figueiró, R Sadeghi, R Sadeghi, R Zarkami, R Zarkami, S Barry, S Katsanevakis, Seblework Mekonen, SN Wood, ST Mereta, T D’heygere, T Hastie, Taffere Addis, TH Hoang, W Lechthaler   +40 more
core   +8 more sources