Results 1 to 10 of about 696,036 (402)

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

Nature Genetics, 2020
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution1–3; however, its frequency and clinical impact are unclear.
Amit D Gujar, Eunhee Yi, Jens Luebeck
exaly   +2 more sources

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

Nature, 2018
Oncogene-induced DNA replication stress contributes critically to the genomic instability that is present in cancer. However, elucidating how oncogenes deregulate DNA replication has been impeded by difficulty in mapping replication initiation sites on ...
Thanos D Halazonetis
exaly   +2 more sources

Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer. [PDF]

, 2013
Pregnancy-associated breast cancers (PABCs) are tumors diagnosed during pregnancy or up to 5 years following parturition, and are usually high-grade, connective tissue-rich, and estrogen receptor (ER)/progesterone receptor-negative. Little is known about
Aina, OH, Cardiff, RD, Dong, J, Haricharan, S, Hein, SM, Li, Y, Rao, PH, Toneff, MJ   +7 more
core   +27 more sources

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences [PDF]

Nature, 1984
Julian Downward, Yosef Yarden, E. L. V. Mayes, Geoffrey Scrace, Nicholas F. Totty, Peter A. Stockwell, A. Ullrich, Joseph Schlessinger, Michael D. Waterfield   +8 more
openalex   +2 more sources

New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network

Frontiers in Molecular Biosciences, 2017
Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of ...
Yi Cui, Kecheng Zhou
exaly   +2 more sources

A microRNA polycistron as a potential human oncogene

Nature, 2005
David Mu, Carlos Cordon-cardo
exaly   +2 more sources

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution

Nature Reviews Cancer, 2019
Paul S Mischel, Roel Gw Verhaak, Vineet Bafna   +2 more
exaly   +2 more sources

Editorial Expression of Concern: Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma [PDF]

Molecular Cancer
Satyabrata Sinha, Ratnesh K. Singh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda   +5 more
doaj   +2 more sources

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

Scientific Reports, 2023
P110α is a member of the phosphoinositide 3-kinase (PI3K) enzyme family that functions downstream of RAS. RAS proteins contribute to the activation of p110α by interacting directly with its RAS binding domain (RBD), resulting in the promotion of many ...
Mohamed Ismail, Stephen R. Martin, Roger George, Francesca Houghton, Geoff Kelly, Raphaël A. G. Chaleil, Panayiotis Anastasiou, Xinyue Wang, Nicola O’Reilly, Stefania Federico, Dhira Joshi, Hemavathi Nagaraj, Rachel Cooley, Ning Sze Hui, Miriam Molina-Arcas, David C. Hancock, Ali Tavassoli, Julian Downward   +17 more
doaj   +1 more source

Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Non-small cell lung cancer (NSCLC) patients bearing targetable oncogene alterations typically derive limited benefit from immune checkpoint blockade (ICB), which has been attributed to low tumor mutation burden (TMB) and/or PD-L1 levels.
M. Negrão, F. Skoulidis, M. Montesion, K. Schulze, I. Bāra, V. Shen, Hao Xu, S. Hu, D. Sui, Y. Elamin, X. Le, M. Goldberg, K. Murugesan, Chang-Jiun Wu, Jianhua Zhang, David S. Barreto, J. Robichaux, A. Reuben, T. Cascone, C. Gay, K. Mitchell, L. Hong, W. Rinsurongkawong, J. Roth, S. Swisher, Jack J. Lee, A. Tsao, V. Papadimitrakopoulou, D. Gibbons, B. Glisson, G. Singal, V. Miller, B. Alexander, G. Frampton, L. Albacker, D. Shames, Jianjun Zhang, J. Heymach   +37 more
semanticscholar   +1 more source