Results 1 to 10 of about 577,954 (290)

Retraction Note: High nuclear expression of HIF1α, synergizing with inactivation of LIMD1 and VHL, portray worst prognosis among the bladder cancer patients: association with arsenic prevalence [PDF]

Journal of Cancer Research and Clinical Oncology
Mukta Basu, Amvrin Chatterjee, Balarko Chakraborty, Essha Chatterjee, Sabnam Ghosh, Sudip Samadder, Dilip Kumar Pal, Anup Roy, Jayanta Chakrabarti, Amlan Ghosh, Chinmay Kumar Panda   +10 more
doaj   +2 more sources

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

Scientific Reports, 2023
P110α is a member of the phosphoinositide 3-kinase (PI3K) enzyme family that functions downstream of RAS. RAS proteins contribute to the activation of p110α by interacting directly with its RAS binding domain (RBD), resulting in the promotion of many ...
Mohamed Ismail, Stephen R. Martin, Roger George, Francesca Houghton, Geoff Kelly, Raphaël A. G. Chaleil, Panayiotis Anastasiou, Xinyue Wang, Nicola O’Reilly, Stefania Federico, Dhira Joshi, Hemavathi Nagaraj, Rachel Cooley, Ning Sze Hui, Miriam Molina-Arcas, David C. Hancock, Ali Tavassoli, Julian Downward   +17 more
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β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells

Communications Biology, 2021
Woei-Yaw Chee et al. explore the molecular mechanisms of β-catenin involvement in cholesterol metabolism suppressing cellular senescence in naked mole-rat cells.
Woei-Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada   +9 more
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Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

Nature Communications, 2021
The tumour microenvironment (TME) may change in response to cancer treatments such as KRAS G12C inhibition, with potential implications for combination therapies. Here, the authors provide an antibody panel and workflow for analysing the TME with imaging
Febe van Maldegem, Karishma Valand, Megan Cole, Harshil Patel, Mihaela Angelova, Sareena Rana, Emma Colliver, Katey Enfield, Nourdine Bah, Gavin Kelly, Victoria Siu Kwan Tsang, Edurne Mugarza, Christopher Moore, Philip Hobson, Dina Levi, Miriam Molina-Arcas, Charles Swanton, Julian Downward   +17 more
doaj   +1 more source

Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer

EMBO Molecular Medicine, 2020
Triple‐negative breast cancer (TNBC) has poorer prognosis compared to other types of breast cancers due to the lack of effective therapies and markers for patient stratification.
Davide Zecchin, Christopher Moore, Fanourios Michailidis, Stuart Horswell, Sareena Rana, Michael Howell, Julian Downward   +6 more
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Exploiting RIG-I-like receptor pathway for cancer immunotherapy

Journal of Hematology & Oncology, 2023
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or bacterial infection and induce host innate immune responses.
Yangfu Jiang, Hongying Zhang, Jiao Wang, Jinzhu Chen, Zeyu Guo, Yongliang Liu, Hui Hua   +6 more
doaj   +1 more source

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

Nature Communications, 2022
Mutations in RAS oncogenes and related pathways are frequent in lung cancers. Here, the authors derive a RAS gene expression signature and a machine learning classifier to predict drug response and clinical outcomes in lung adenocarcinoma and other solid
Philip East, Gavin P. Kelly, Dhruva Biswas, Michela Marani, David C. Hancock, Todd Creasy, Kris Sachsenmeier, Charles Swanton, TRACERx consortium, Julian Downward, Sophie de Carné Trécesson   +10 more
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Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data

Cancer Biology & Medicine, 2022
This review will describe the global patterns and trends of colorectal cancer survival, using data from the population-based studies or cancer registration. We performed a systematic search of China National Knowledge Infrastructure (CNKI), Wanfang Data,
Yufei Jiang, Huiyun Yuan, Zhuoying Li, Xiaowei Ji, Qiuming Shen, Jiayi Tuo, Jinghao Bi, Honglan Li, Yongbing Xiang   +8 more
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SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion

Experimental Hematology & Oncology, 2021
Background Hepatocellular carcinoma (HCC) is one of the common cancers that are very aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer metastasis by multiple mechanisms such as epithelial-mesenchymal transition and ...
Shu Yang, Hongying Zhang, Hua Yang, Jin Zhang, Jiao Wang, Ting Luo, Yangfu Jiang, Hui Hua   +7 more
doaj   +1 more source

Targeting Akt in cancer for precision therapy

Journal of Hematology & Oncology, 2021
Biomarkers-guided precision therapeutics has revolutionized the clinical development and administration of molecular-targeted anticancer agents. Tailored precision cancer therapy exhibits better response rate compared to unselective treatment.
Hui Hua, Hongying Zhang, Jingzhu Chen, Jiao Wang, Jieya Liu, Yangfu Jiang   +5 more
doaj   +1 more source