Results 11 to 20 of about 825,198 (275)
Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. [PDF]
, 2015 The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental
Bosco MC +10 more
core +1 more source
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion
Experimental Hematology & Oncology, 2021 Background Hepatocellular carcinoma (HCC) is one of the common cancers that are very aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer metastasis by multiple mechanisms such as epithelial-mesenchymal transition and ...
Shu Yang +7 more
doaj +1 more source
Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]
, 1989 Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A. +5 more
core +2 more sources
BioMed Research International, 2014 No abstract available.
Rita de Cassia Stocco +3 more
openaire +4 more sources
Scandinavian Journal of Gastroenterology, 1985 The central problem in cancer therapy is the poor selectivity of current systemic agents against the common solid tumours. The demonstration that unique segments of DNA, constant in location and conserved in evolution are involved in growth control opens new avenues for basic and clinical research.
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Dietary fat intake and liver cancer risk: A prospective cohort study in Chinese women
Cancer Biology & Medicine, 2022 Objective: This study aimed to determine whether dietary fat intake increased liver cancer risk in Chinese women from a prospective population-based cohort.
Xiaowei Ji +8 more
doaj +1 more source
Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]
, 2015 BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir +7 more
core +2 more sources
Cancer Research, 2008 Abstract Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called “oncogene addiction,” provides a rationale for molecular targeted therapy.
I Bernard, Weinstein, Andrew, Joe
openaire +2 more sources
Targeting Akt in cancer for precision therapy
Journal of Hematology & Oncology, 2021 Biomarkers-guided precision therapeutics has revolutionized the clinical development and administration of molecular-targeted anticancer agents. Tailored precision cancer therapy exhibits better response rate compared to unselective treatment.
Hui Hua +5 more
doaj +1 more source
Journal of Hematology & Oncology, 2020 Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in ...
Hui Hua +4 more
doaj +1 more source