Results 11 to 20 of about 657,003 (258)

Asparagine bioavailability regulates the translation of MYC oncogene

, 2022
Amino acid restriction has recently emerged as a compelling strategy to inhibit tumor growth. Recent work suggests that amino acids can regulate cellular signaling in addition to their role as biosynthetic substrates.
Chen, Chong, Misra, Jagannath, Liu, Yu, Zhang, Ji, Staschke, Kirk A., Zhou, Jiehao, Kapur, Reuben, Zhong, Minghua, Fan, Jing, Srivastava, Sankalp, Davé, Utpal, Zhang, Chi, Seim, Gretchen, Batra, Sandeep, Jiang, Jie, Zhou, Leonardo, Wek, Ronald C.   +16 more
core   +1 more source

Blocakde of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas [PDF]

, 2000
Smad4 functions as a transcription factor TGF-β signalling. We have investigated the role of Smad4 in the TGF-β1 cell responses of transformed PDV keratinocytes, wich contain a Ras oncogene, and of nontumorigenic MCA3D keratinocytes, by transfecting both
Frontelo, Pilar, Iglesias Badiola, Maite, Gamallo, Carlos, Quintanilla, Miguel   +3 more
core   +2 more sources

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy

Journal of Hematology & Oncology, 2020
Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in ...
Hui Hua, Qingbin Kong, Jie Yin, Jin Zhang, Yangfu Jiang   +4 more
doaj   +1 more source

Mechanisms for estrogen receptor expression in human cancer

Experimental Hematology & Oncology, 2018
Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis.
Hui Hua, Hongying Zhang, Qingbin Kong, Yangfu Jiang   +3 more
doaj   +1 more source

RETRACTED: Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1‐24.2 region in breast carcinoma: Clinical and prognostic implications

Molecular Oncology, 2011
To understand the importance of frequent deletions at chromosome 11q24.1‐24.2 region in breast carcinoma, alterations (deletion/methylation) of the candidate genes LOH11CR2A, ROBO3, ROBO4, HEPACAM, PIG8 and CHEK1 located in this region were analyzed in ...
Satyabrata Sinha, Ratnesh K. Singh, Nilanjana Bhattacharya, Nupur Mukherjee, Susmita Ghosh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda   +8 more
doaj   +1 more source

Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies

BMC Cancer, 2020
Background Epidemiological studies on the association between coffee intake and cancer risk have yielded inconsistent results. To summarize and appraise the quality of the current evidence, we conducted an umbrella review of existing findings from meta ...
Long-Gang Zhao, Zhuo-Ying Li, Guo-Shan Feng, Xiao-Wei Ji, Yu-Ting Tan, Hong-Lan Li, Marc J. Gunter, Yong-Bing Xiang   +7 more
doaj   +1 more source

Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Journal of Hematology & Oncology, 2022
Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion.
Yangfu Jiang, Hongying Zhang, Jiao Wang, Yongliang Liu, Ting Luo, Hui Hua   +5 more
doaj   +1 more source

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Nature Communications, 2016
Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blocking
Esther Castellano, Miriam Molina-Arcas, Agata Adelajda Krygowska, Philip East, Patricia Warne, Alastair Nicol, Julian Downward   +6 more
doaj   +1 more source

Oncogene inactivation-induced senescence facilitates tumor relapse. [PDF]

Nat Commun
Oncogene-directed therapies can induce profound tumor regression in oncogene-addicted cancers, but their long-term benefit is often limited by resistance and relapse.
Schmitt P, Hönig K, Norcia MT, Nogueira MF, Flore V, Vesperinas IS, Villoro-Agud M, Peng L, Safyürek Z, Tariq M, Milojkovic A, Anders K, Schröck E, Sauer S, Uyar B, Akalin A, Willimsky G, Haas S, Martínez-Reyes I, Blankenstein T.   +19 more
europepmc   +2 more sources

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Yuh-Hwa Wang (457429), Dillon, LW, Yuh-Hwa Wang, Christine E. Lehman (457427), Laura W Dillon, Dillon Laura W., Nikiforov Yuri E., Pierce Levi C. T., Wang, YH, Laura W. Dillon (457426), Lehman, Christine E., Christine E Lehman, Lehman, CE, Pierce, Levi C. T., Nikiforov, Yuri E., Pierce, LCT, Yuri E. Nikiforov (457428), Levi C T Pierce, Rybenkov, Valentin V, Wang, Yuh-Hwa, Wang Yuh-Hwa, Levi C. T. Pierce (454414), Lehman Christine E., Yuri E Nikiforov, Dillon, Laura W., Nikiforov, YE   +25 more
core   +2 more sources