Results 11 to 20 of about 571,490 (260)
Targeting Akt in cancer for precision therapy
Journal of Hematology & Oncology, 2021 Biomarkers-guided precision therapeutics has revolutionized the clinical development and administration of molecular-targeted anticancer agents. Tailored precision cancer therapy exhibits better response rate compared to unselective treatment.
Hui Hua +5 more
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Journal of Hematology & Oncology, 2020 Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in ...
Hui Hua +4 more
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Mechanisms for estrogen receptor expression in human cancer
Experimental Hematology & Oncology, 2018 Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis.
Hui Hua +3 more
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Molecular Oncology, 2011 To understand the importance of frequent deletions at chromosome 11q24.1‐24.2 region in breast carcinoma, alterations (deletion/methylation) of the candidate genes LOH11CR2A, ROBO3, ROBO4, HEPACAM, PIG8 and CHEK1 located in this region were analyzed in ...
Satyabrata Sinha +8 more
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Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies
BMC Cancer, 2020 Background Epidemiological studies on the association between coffee intake and cancer risk have yielded inconsistent results. To summarize and appraise the quality of the current evidence, we conducted an umbrella review of existing findings from meta ...
Long-Gang Zhao +7 more
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Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy
Journal of Hematology & Oncology, 2022 Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion.
Yangfu Jiang +5 more
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BioMed Research International, 2014 No abstract available.
Rita de Cassia Stocco +3 more
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RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
Nature Communications, 2016 Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blocking
Esther Castellano +6 more
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Proto‐oncogenes and oncogenes in epidermal neoplasia [PDF]
Experimental Dermatology, 1995 Abstract This review briefly will focus on the role of selected proto‐onco‐genes and their activated forms during the regulation of cell proliferation, cell death and tumor formation in the epidermis. In addition, the multiple and complex functions of these proteins in normal as well as transformed cells will be discussed.
M M, Simon, G, Sliutz, T A, Luger
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The ANXA2/S100A10 Complex—Regulation of the Oncogenic Plasminogen Receptor
Biomolecules, 2021 The generation of the serine protease plasmin is initiated by the binding of its zymogenic precursor, plasminogen, to cell surface receptors.
Alamelu G. Bharadwaj +2 more
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