Results 21 to 30 of about 696,036 (402)
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion
Experimental Hematology & Oncology, 2021 Background Hepatocellular carcinoma (HCC) is one of the common cancers that are very aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer metastasis by multiple mechanisms such as epithelial-mesenchymal transition and ...
Shu Yang +7 more
doaj +1 more source
Dietary fat intake and liver cancer risk: A prospective cohort study in Chinese women
Cancer Biology & Medicine, 2022 Objective: This study aimed to determine whether dietary fat intake increased liver cancer risk in Chinese women from a prospective population-based cohort.
Xiaowei Ji +8 more
doaj +1 more source
An Integrated Deep Learning and Dynamic Programming Method for Predicting Tumor Suppressor Genes, Oncogenes, and Fusion from PDB Structures [PDF]
Computers in Biology and Medicine, Volume 133, 2021, 104323, ISSN
0010-4825, 2021 Mutations in proto-oncogenes (ONGO) and the loss of regulatory function of tumor suppression genes (TSG) are the common underlying mechanism for uncontrolled tumor growth. While cancer is a heterogeneous complex of distinct diseases, finding the potentiality of the genes related functionality to ONGO or TSG through computational studies can help ...
arxiv +1 more source
Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. [PDF]
, 2015 The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental
Bosco MC +10 more
core +1 more source
Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]
, 1989 Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A. +5 more
core +2 more sources
The double dealing of cyclin D1 [PDF]
Cell Cycle, Taylor & Francis, 2010, pp.1-16, 2020 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
arxiv +1 more source
Targeting Akt in cancer for precision therapy
Journal of Hematology & Oncology, 2021 Biomarkers-guided precision therapeutics has revolutionized the clinical development and administration of molecular-targeted anticancer agents. Tailored precision cancer therapy exhibits better response rate compared to unselective treatment.
Hui Hua +5 more
doaj +1 more source
A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma. [PDF]
, 2011 MicroRNAs (miRNAs) are small ∼22nt single stranded RNAs that negatively regulate protein expression by binding to partially complementary sequences in the 3' untranslated region (3' UTRs) of target gene messenger RNAs (mRNA).
Ariyan, S +16 more
core +1 more source
Oncogenes and anti-oncogenes in tumorigenesis [PDF]
Reproduction Nutrition Développement, 1990 Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences.
openaire +4 more sources
Journal of Hematology & Oncology, 2020 Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in ...
Hui Hua +4 more
doaj +1 more source