Results 21 to 30 of about 617,669 (345)

Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest [PDF]

, 2015
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown.
Adams, Peter D., Athineos, Dimitris, Berger, Shelley L., Blyth, Karen, Brock, Claire, Clark, William, Cole, John J., Dikovskaya, Dina, Hewitt, Rachael N., Karim, Saadia A., Leach, Joshua D. G., Marchesi, Francesco, Mason, Susan M., McGarry, Lynn, Morton, Jennifer P., Nixon, Colin, Sammons, Morgan A., Tait, Stephen W., van Tuyn, John, Wu, Hong, Zhu, Jiajun   +20 more
core   +2 more sources

Mechanisms for estrogen receptor expression in human cancer

Experimental Hematology & Oncology, 2018
Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis.
Hui Hua, Hongying Zhang, Qingbin Kong, Yangfu Jiang   +3 more
doaj   +1 more source

Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Journal of Hematology & Oncology, 2022
Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion.
Yangfu Jiang, Hongying Zhang, Jiao Wang, Yongliang Liu, Ting Luo, Hui Hua   +5 more
doaj   +1 more source

Targeting Splicing Factor SRSF6 for Cancer Therapy

Frontiers in Cell and Developmental Biology, 2021
Aberrant alternative splicing of pre-mRNA is an emerging cancer hallmark. Many cancer-associated genes undergo alternative splicing to produce multiple isoforms with diverse or even antagonistic functions.
Wenting She, Wenting She, Jun Shao, Rong Jia   +3 more
doaj   +1 more source

Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies

BMC Cancer, 2020
Background Epidemiological studies on the association between coffee intake and cancer risk have yielded inconsistent results. To summarize and appraise the quality of the current evidence, we conducted an umbrella review of existing findings from meta ...
Long-Gang Zhao, Zhuo-Ying Li, Guo-Shan Feng, Xiao-Wei Ji, Yu-Ting Tan, Hong-Lan Li, Marc J. Gunter, Yong-Bing Xiang   +7 more
doaj   +1 more source

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Nature Communications, 2016
Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blocking
Esther Castellano, Miriam Molina-Arcas, Agata Adelajda Krygowska, Philip East, Patricia Warne, Alastair Nicol, Julian Downward   +6 more
doaj   +1 more source

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]

, 2015
BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir, Lewis, Michael, Lu, Jie, Mortazavi, Fariborz, Pezeshkpour, Gholamhossein, Phan, Ryan, Tamanoi, Fuyuhiko, Trinidad, Kenny   +7 more
core   +2 more sources

RETRACTED: Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1‐24.2 region in breast carcinoma: Clinical and prognostic implications

Molecular Oncology, 2011
To understand the importance of frequent deletions at chromosome 11q24.1‐24.2 region in breast carcinoma, alterations (deletion/methylation) of the candidate genes LOH11CR2A, ROBO3, ROBO4, HEPACAM, PIG8 and CHEK1 located in this region were analyzed in ...
Satyabrata Sinha, Ratnesh K. Singh, Nilanjana Bhattacharya, Nupur Mukherjee, Susmita Ghosh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda   +8 more
doaj   +1 more source

Reviewing Oncogenes and Proto-Oncogenes

International Journal of Scientific Research in Science and Technology, 2021
This article is an examination of the Reviewing oncogenes and Proto-oncogenes The scientific development and subsequent “oncogenes and Proto-oncogenes” continues to influence the researchers all over the globe today. This article examines the research done and published by researchers and scientists.
Nehal Batra, Ishita Ghag, Karishma Babu, Tejaswini Divanji   +3 more
openaire   +2 more sources

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer [PDF]

, 2017
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative ...
Andersen, Jesper B., Arricibita, Andrea, Bailey, Peter, Biankin, Andrew, Bozec, Aline, Chang, David K., Chuang, Chen-Hua, Guembe, Laura, Guruceaga, Elisabet, Gwinn, Dana, Khatri, Purvesh, Lecanda, Fernando, Martinez-Canarias, Susana, Mazur, Pawel K., Perurena, Naiara, Ponz-Sarvise, Mariano, Sage, Julien, Sayles, Leanne C., Sweet-Cordero, E. Alejandro, Valencia, Karmele, Vallejo, Adrian, Vicent, Silve, Zandueta, Carolina   +22 more
core   +3 more sources