Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer. [PDF]
PLoS ONE, 2015 TMPRSS2-ERG junction oncogene is present in more than 50% of patients with prostate cancer and its expression is frequently associated with poor prognosis.
Giorgia Urbinati +6 more
doaj +2 more sources
p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]
Haematologica, 2012 Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian +5 more
doaj +4 more sources
Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance
Nature CommunicationsDrug resistance remains a challenge for targeted therapy of cancers driven by EML4-ALK and related fusion oncogenes. EML4-ALK forms cytoplasmic protein condensates, which result from networks of interactions between oncogene and adapter protein multimers.
David Gonzalez-Martinez +10 more
doaj +2 more sources
MOLECULAR RELAPSE OF ACUTE PROMYELOCYTIC LEUKEMIA AFTER COMPLETE REMISSION: A CASE REPORT AND LITERATURE REVIEW [PDF]
精准医学杂志, 2023 Objective To investigate the molecular biological changes of relapsed acute promyelocytic leukemia (APL), and to provide guidance for the clinical diagnosis and treatment of relapsed APL.
CHEN Junru, WANG Yilin, WANG Lingzhen, JIANG Jian, SUN Yan, LU Yuan
doaj +1 more source
The RARγ Oncogene: An Achilles Heel for Some Cancers
International Journal of Molecular Sciences, 2021 Cancer “stem cells” (CSCs) sustain the hierarchies of dividing cells that characterize cancer. The main causes of cancer-related mortality are metastatic disease and relapse, both of which originate primarily from CSCs, so their eradication may provide a
Geoffrey Brown, K. Petrie
semanticscholar +1 more source
Genetic fusions favor tumorigenesis through degron loss in oncogenes
Nature Communications, 2021 Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in tumorigenesis and progression.
Jing Liu +7 more
doaj +1 more source
A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. [PDF]
, 2016 The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers.
Babicky, M +10 more
core +7 more sources
Adenoid cystic carcinoma: emerging role of translocations and gene fusions. [PDF]
, 2016 Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease.
Brait, Mariana +5 more
core +6 more sources
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
Nature Communications, 2020 The oncogene MLL is frequently translocated in leukemia, resulting in oncogenic fusion proteins. Here, the authors report a temporally controlled mouse model of MLL-ENL driven leukemia AND identify therapeutic targets associated with early MLL-ENL driven
Silvia Basilico +13 more
doaj +1 more source
The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1. [PDF]
PLoS ONE, 2009 This study demonstrates deregulation of polycomb activity by the synovial sarcoma-associated SYT-SSX2 oncogene, also known as SS18-SSX2. Synovial sarcoma is a soft tissue cancer associated with a recurrent t(X:18) translocation event that generates one ...
Roy Barco +2 more
doaj +1 more source