Results 21 to 30 of about 369,580 (326)

Detecting and targetting oncogenic fusion proteins in the genomic era [PDF]

Biology of the Cell, 2015
The advent of widespread cancer genome sequencing has accelerated our understanding of the molecular aberrations underlying malignant disease at an unprecedented rate. Coupling the large number of bioinformatic methods developed to locate genomic breakpoints with increased sequence read length and a deeper understanding of coding region function has ...
Monika A, Davare, Cristina E, Tognon
openaire   +2 more sources

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

Cell Reports, 2015
Transcription factor fusion proteins can transform cells by inducing global changes of the transcriptome, often creating a state of oncogene addiction.
Eleni M. Tomazou, Nathan C. Sheffield, Christian Schmidl, Michael Schuster, Andreas Schönegger, Paul Datlinger, Stefan Kubicek, Christoph Bock, Heinrich Kovar   +8 more
doaj   +1 more source

MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways

Scientific Reports, 2023
Gene fusions caused by cytogenetic aberrations play important roles in the initiation and progression of cancers. The recurrent MTAP-ANRIL fusion gene was reported to have a frequency of greater than 7% in melanoma in our previous study.
Zhuoying Lin, Yu Lei, Mingyao Wen, Qin He, Dean Tian, Huaping Xie   +5 more
doaj   +1 more source

FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium [PDF]

Oncogene, 2018
Structural rearrangements of the genome can drive lung tumorigenesis through the generation of fusion genes with oncogenic properties. Advanced genomic approaches have identified the presence of a genetic fusion between fibroblast growth factor receptor 3 (FGFR3) and transforming acidic coiled-coil 3 (TACC3) in non-small cell lung cancer (NSCLC ...
Sarah A. Best, Cassandra R. Harapas, Ariena Kersbergen, Vivek Rathi, Marie-Liesse Asselin-Labat, Kate D. Sutherland   +5 more
openaire   +3 more sources

FOP is a centriolar satellite protein involved in ciliogenesis. [PDF]

PLoS ONE, 2013
Centriolar satellites are proteinaceous granules that are often clustered around the centrosome. Although centriolar satellites have been implicated in protein trafficking in relation to the centrosome and cilium, the details of their function and ...
Joanna Y Lee, Tim Stearns
doaj   +1 more source

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

Frontiers in Oncology, 2023
Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment of de
Tamara Vital, Tamara Vital, Aminah Wali, Aminah Wali, Kyle V. Butler, Kyle V. Butler, Kyle V. Butler, Yan Xiong, Yan Xiong, Yan Xiong, Joseph P. Foster, Joseph P. Foster, Shelsa S. Marcel, Shelsa S. Marcel, Andrew W. McFadden, Valerie U. Nguyen, Benton M. Bailey, Kelsey N. Lamb, Lindsey I. James, Lindsey I. James, Stephen V. Frye, Stephen V. Frye, Amber L. Mosely, Amber L. Mosely, Jian Jin, Jian Jin, Jian Jin, Samantha G. Pattenden, Samantha G. Pattenden, Ian J. Davis, Ian J. Davis, Ian J. Davis   +31 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

c-Fos and Dusp1 confer non-oncogene addiction in BCR-ABL induced leukemia

Nature Medicine, 2017
Tyrosine-kinase inhibitor (TKI) therapy for human cancers is not curative, and relapse occurs owing to the continued presence of tumor cells, referred to as minimal residual disease (MRD).
M. Kesarwani, Zachary Kincaid, A. Gomaa, E. Huber, Sara L. Rohrabaugh, Z. Siddiqui, Muhammad F Bouso, T. Latif, Ming-zheng Xu, K. Komurov, J. Mulloy, J. Cancelas, H. Grimes, M. Azam   +13 more
semanticscholar   +1 more source

Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview

Revista Brasileira de Hematologia e Hemoterapia, 2015
Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative ...
Renata Mendes de Freitas, Carlos Magno da Costa Maranduba   +1 more
doaj   +1 more source

The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]

, 2018
PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core   +2 more sources