Results 221 to 230 of about 377,702 (260)
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Journal of Cellular Physiology, 2012
AbstractThe retinoblastoma (RB) family consists of three genes, RB1, RBL1, and RBL2, that code for the pRb, p107, and pRb2/p130 proteins, respectively. All these factors have pivotal roles in controlling fundamental cellular mechanisms such as cell cycle, differentiation and apoptosis.
Emanuele, Bellacchio, Marco G, Paggi
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AbstractThe retinoblastoma (RB) family consists of three genes, RB1, RBL1, and RBL2, that code for the pRb, p107, and pRb2/p130 proteins, respectively. All these factors have pivotal roles in controlling fundamental cellular mechanisms such as cell cycle, differentiation and apoptosis.
Emanuele, Bellacchio, Marco G, Paggi
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Journal of Molecular Biology, 2011
Hepatitis B X-interacting protein (HBXIP) is a ubiquitous protein that was originally identified as a binding partner of the hepatitis B viral protein HBx. HBXIP is also thought to serve as an anti-apoptotic cofactor of survivin, promoting the suppression of pro-caspase-9 activation. Here were port the crystal structure of the shortest isoform of HBXIP
I, Garcia-Saez +4 more
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Hepatitis B X-interacting protein (HBXIP) is a ubiquitous protein that was originally identified as a binding partner of the hepatitis B viral protein HBx. HBXIP is also thought to serve as an anti-apoptotic cofactor of survivin, promoting the suppression of pro-caspase-9 activation. Here were port the crystal structure of the shortest isoform of HBXIP
I, Garcia-Saez +4 more
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DNA and Cell Biology, 2004
The latent membrane protein-1 (LMP1) of Epstein-Barr Virus (EBV), saimiri transformation protein (STP) of Herpesvirus saimiri (HVS), and K1 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) are potent gammaherpesvirus oncogenes. To study the possible effects of double viral infection, we investigated the effects of oncogenic early proteins of ...
Barnabe Dossou, Assogba +2 more
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The latent membrane protein-1 (LMP1) of Epstein-Barr Virus (EBV), saimiri transformation protein (STP) of Herpesvirus saimiri (HVS), and K1 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) are potent gammaherpesvirus oncogenes. To study the possible effects of double viral infection, we investigated the effects of oncogenic early proteins of ...
Barnabe Dossou, Assogba +2 more
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Oncogenic γ-herpesviruses: comparison of viral proteins involved in tumorigenesis
Nature Reviews Microbiology, 2004Herpesviruses are present in most species throughout the animal kingdom and are classified into three subfamilies, α, β and γ, on the basis of their biological properties and genome sequences. A striking feature that is shared by many of the γ-herpesviruses is their ability to induce neoplastic disease in the host.
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Induction of an oncogenic fusion protein by a viral gene—a new chapter in an old story
Nature Medicine, 1999A combination of 19th century cytology and 20th century molecular biology has uncovered a previously unknown mechanism by which viruses may contribute to carcinogenesis ( pages 1076–1079 ).
David Kirn, Terry Hermiston
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Cell, 1990
The v-erbA oncogene is a retrovirus-transduced and altered copy of a cellular gene for a thyroid hormone receptor. In animal cells, the v-erbA protein fails to respond to hormone and acts as a dominant negative allele, inhibiting gene activation normally conferred by the wild-type thyroid hormone receptor.
M L, Privalsky, M, Sharif, K R, Yamamoto
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The v-erbA oncogene is a retrovirus-transduced and altered copy of a cellular gene for a thyroid hormone receptor. In animal cells, the v-erbA protein fails to respond to hormone and acts as a dominant negative allele, inhibiting gene activation normally conferred by the wild-type thyroid hormone receptor.
M L, Privalsky, M, Sharif, K R, Yamamoto
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Nature, 1998
The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Kaposi's sarcoma pathogenesis by ...
C, Bais +10 more
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The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Kaposi's sarcoma pathogenesis by ...
C, Bais +10 more
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Journal of Virology, 1984
Several nononcogenic cyt mutants of adenovirus type 12 induced the same E1A (55,000 [55K] and 25K) and E1B polypeptides (55K, 19K, and 17K) as did the wild-type virus, except that cyt 68 did not induce the E1B 19K protein. Tumorigenicity tests showed cells transformed by cyt 68 to be highly oncogenic in vivo.
I, Mak, H, Galet, S, Mak
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Several nononcogenic cyt mutants of adenovirus type 12 induced the same E1A (55,000 [55K] and 25K) and E1B polypeptides (55K, 19K, and 17K) as did the wild-type virus, except that cyt 68 did not induce the E1B 19K protein. Tumorigenicity tests showed cells transformed by cyt 68 to be highly oncogenic in vivo.
I, Mak, H, Galet, S, Mak
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Journal of Hepatology, 2012
Apicobasal polarity, which is essential for epithelial structure and function, is targeted by several tumour-related pathogens and is generally perturbed in the course of carcinogenesis. Hepatitis C virus (HCV) infection is associated with a strong risk of hepatocellular carcinoma, typically preceded by dysplastic alterations of cell morphology.
Akkari*, L. +8 more
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Apicobasal polarity, which is essential for epithelial structure and function, is targeted by several tumour-related pathogens and is generally perturbed in the course of carcinogenesis. Hepatitis C virus (HCV) infection is associated with a strong risk of hepatocellular carcinoma, typically preceded by dysplastic alterations of cell morphology.
Akkari*, L. +8 more
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1995
For more than 15 years human adenoviruses (Ad) have been a powerful tool for studying cellular processes such as regulation of gene expression, alternative splicing, polyadenylation, and replication. Especially the analysis of viral proteins encoded by early region 1A (E1A), which was shown to regulate transcription, has given many insights into how ...
D, Brockmann, H, Esche
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For more than 15 years human adenoviruses (Ad) have been a powerful tool for studying cellular processes such as regulation of gene expression, alternative splicing, polyadenylation, and replication. Especially the analysis of viral proteins encoded by early region 1A (E1A), which was shown to regulate transcription, has given many insights into how ...
D, Brockmann, H, Esche
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