Results 241 to 250 of about 2,503,880 (309)

Targeting the autophagic network: A new frontier in colorectal cancer chemotherapy response. [PDF]

Cytojournal
Kyrochristou I, Bali C, Mitsis M, Vlachos K, Lianos G.   +4 more
europepmc   +1 more source

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source

Modulation of DNA Damage by Epstein-Barr Virus (EBV). [PDF]

Viruses
DiMaulo-Milk E, Damania B.
europepmc   +1 more source

Catalysis and allostery in bacterial ATP phosphoribosyltransferases

The FEBS Journal, EarlyView.
ATP phosphoribosyltransferase (ATPPRT) catalyses the first reaction of L‐histidine biosynthesis. L‐Histidine allosterically inhibits ATPPRT to regulate this energy‐intensive pathway in histidine‐synthesising organisms, such as bacteria, archaea and plants.
Lillian G. Bates, Rafael G. da Silva
wiley   +1 more source

Serum-based BRAF V600E detection improves early diagnosis of papillary thyroid carcinoma: A prospective diagnostic accuracy study compared with ultrasound-guided cytology. [PDF]

Medicine (Baltimore)
Li Q, Lu Y, Li X, Jiang J, Wang X, Xu J, Zhang Q, Zhao L.   +7 more
europepmc   +1 more source

An Integrative Multi‐Omic Biomarker Panel Distinguishes Hepatocellular Carcinoma From Chronic Liver Disease in HBV‐Predominant Populations

Hepatology Research, EarlyView.
ABSTRACT Aim DNA methylation is a promising diagnostic biomarker for various cancers including hepatocellular carcinoma (HCC). We aimed to identify aberrant DNA methylation and protein alterations via integrated approaches and develop a highly predictive biomarker panel for blood‐based discrimination of HCC from non‐HCC chronic liver disease (CLD) in ...
Hao Zhuang, Xiaopei Hao, Tingting Zhang, Deqiang Li, Guanghao Li, Zhongyi Li, Yuanlin Xu, Shuaiya Ma, Xiangjun Qian, Bo Meng, Xianzhou Zhang, Tiantian Zheng, Feng Han, Hao Wang, Yongmei Li, Nanmu Yang   +15 more
wiley   +1 more source

Lipid reprogramming of stratified squamous epithelium by the high-risk HPV E6 and E6/E7 oncoproteins. [PDF]

Metabolomics
Spurgeon ME, Lange TE, Baty A, Li H, Lambert PF, Setchell KDR, Wells SI, Zhao X.   +7 more
europepmc   +1 more source

The Biological Basis of the Merlin CP‐GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma

International Journal of Dermatology, EarlyView.
Merlin CP‐GEP integrates mechanistic insights into a clinically actionable assay to predict SLN metastasis risk and inform personalized management of cutaneous melanoma. ABSTRACT The recent inclusion of the Merlin clinicopathologic–gene expression profile (CP‐GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents ...
Frank Z. Jing, Alexander Meves
wiley   +1 more source

Functional siRNA Screen Links Ras/MAPK and Wnt Pathway to EV Secretion in HCT-116 Colorectal Cancer Cells. [PDF]

Diseases
Pätzold SM, Gross JC.
europepmc   +1 more source

Unmasking the Influence of Viral Micro‐RNAs on Host Immunity

Immunology &Cell Biology, EarlyView.
Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton, Bernadette M. Saunders   +1 more
wiley   +1 more source