Results 221 to 230 of about 458,798 (262)

Serum Oncogene Proteins in Foundry Workers

Occupational Medicine, 1990
A new technique for detecting oncogene activation based on immunoblotting for oncogene proteins in serum has been applied to screen a cohort of foundry workers with well-defined workplace exposures to polycyclic aromatic hydrocarbon carcinogens. Three of the 18 individuals screened were found to have abnormal expression of the proteins of the ras and ...
P W, Brandt-Rauf, S, Smith, F P, Perera, H L, Niman, W, Yohannan, K, Hemminki, R M, Santella   +6 more
openaire   +2 more sources

Oncogenic protein tyrosine kinases

Cellular and Molecular Life Sciences, 2004
Platelet-derived growth factor receptors (PDGFRs) and their ligands, platelet-derived growth factors (PDGFs) play critical roles in mesenchymal cell migration and proliferation. In embryogenesis the PDGFR/PDGF system is essential for the correct development of the kidney, cardiovascular system, brain, lung and connective tissue.
Jones, A.V., Cross, N.C.P.
  +5 more sources

Oncogenic mechanisms of Evi-1 protein

Cancer Chemotherapy and Pharmacology, 2001
Although Evi-1 is thought to promote growth or block differentiation in some cell types, its biological functions have not been elucidated. To explore the mechanisms underlying Evi-1-induced oncogenesis, we investigated whether Evi-1 affects the signaling of transforming growth factor beta (TGF-beta), which inhibits proliferation of a wide range of ...
H, Hirai, K, Izutsu, M, Kurokawa, K, Mitani   +3 more
openaire   +2 more sources

The ras Oncogene Protein

1989
To date, over 40 discrete genes (oncogenes and proto-oncogenes) have been shown capable of inducing cellular transformation and tumor development (Bishop 1987). Only a few of these oncogenes have actually been shown to have a significant role in human cancer.
M. S. Marshall, M. D. Schaber, U. S. Vogel, W. S. Hill, A. S. Ng, E. M. Scolnick, R. A. F. Dixon, I. S. Sigal, J. B. Gibbs   +8 more
openaire   +1 more source

G protein oncogenes in pituitary tumors

Trends in Endocrinology & Metabolism, 1992
G proteins are involved in the transduction of external signals from cell surface receptors to intracellular effectors. Somatic mutations activating the a-subunit of G(s) (the stimulatory regulatory protein of adenylyl cyclase) by inhibiting its intrinsic GTPase activity have been first identified in human GH-secreting adenomas and subsequently found ...
A, Spada, L, Vallar, G, Faglia
openaire   +2 more sources

Targeting Oncogenic RAS Protein

New England Journal of Medicine, 2022
Dan L, Longo, Neal, Rosen
openaire   +2 more sources

The Oncogenic Role of Human Papillomavirus Proteins

Critical Reviews™ in Oncogenesis, 1996
Each human papillomavirus (HPV) type is genotypically distinct and infects epithelial cells at unique anatomic sites. Among the HPV types described, a subgroup is associated with genital disease and a subset of these is found in 90% of genital cancers. Although in benign infections the viral genome is present as an episome, in cancers it is integrated.
openaire   +2 more sources

Oncogenic Potential and Normal Function of the Proto-Oncogenes Encoding Protein-Tyrosine Kinases

1990
A number of protein-tyrosine kinases, including the cellular counterpart of the src gene product of Rous sarcoma virus, have been identified in mammalian cells and are suggested to be important in growth and/or differentiation of cells. Approximately half of the protein-tyrosine kinases are integral membrane proteins and are, in many cases, receptors ...
T, Yamamoto, T, Akiyama, K, Semba, Y, Yamanashi, K, Inoue, Y, Yamada, J, Sukegawa, K, Toyoshima   +7 more
openaire   +2 more sources

G Protein Oncogenes

1991
This review will describe experiments aimed at answering two questions raised by the recent convergence of research on signal-transducing G proteins and oncogenes: What roles do individual G proteins play in normal regulation of cell proliferation? How do dominantly acting G protein oncogenes contribute to tumorigenesis, in experimental systems and in ...
openaire   +1 more source

Potential oncogenic hazards posed by oncogene encoded proteins.

Developments in biological standardization, 1988
The theoretical risk from oncogene encoded proteins is limited to growth factors, which may be secreted by cells in which biologically derived products might be manufactured. Because these peptides do not replicate, their effect is finite. In addition, their effects are reversible. Growth factors do not ordinarily appear to be oncogenic.
openaire   +1 more source