Results 231 to 240 of about 237,469 (282)

Database of recurrent mutations, an unbiased web resource to browse recurrent mutations in cancers. [PDF]

iScience
Chakroborty D, Vaparanta K, Ghimire B, Paatero I, Kurppa KJ, Elenius K.   +5 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Translating Gastric Cancer Genomics into Targeted Therapy: Mechanistic Insights from Animal Models and Patient-Derived Systems. [PDF]

Cells
Shyu RY, Wang LK, Tsai FM.
europepmc   +1 more source

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

Canadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang, Steven Chen, Raymond Balise, Jiming Jiang, Nagi Ayad, J. Sunil Rao   +5 more
wiley   +1 more source

ELViS: an R package for estimating copy number levels of viral genomic segments at base-resolution. [PDF]

Bioinformatics
Lee JY, Holt JR, Zhao X, Hoadley KA, Hayes DN, Choi HY.   +5 more
europepmc   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Genetic and epigenetic contribution to tamoxifen resistance in breast cancer, concepts to drive therapeutic strategies. [PDF]

Discov Oncol
Jahangiri R.
europepmc   +1 more source

Dysregulation of mRNA splicing in urothelial carcinoma: Clinical, diagnostic and therapeutic implications. [PDF]

Bladder Cancer
Columbres RCA, Apolo AB, Rouf Banday A.
europepmc   +1 more source

Modification‐Response Integrated Modules Driven Cyclization‐Dependent Prodrug Self‐Assembly for Reshaping Pro‐Apoptotic Tumor Redox Homeostasis

Exploration, EarlyView.
1. The concept of modification‐response integrated modules was proposed for the first time. 2. Simple, efficient, and feasible drug delivery platforms were developed for systematic regulation of tumor redox microenvironment and reshaping of pro‐apoptotic tumor redox homeostasis.
Yixin Sun, Shiyi Zuo, Wenfeng Zang, Lingxiao Li, Xianbao Shi, Mingzhong Li, Zhonggui He, Bingjun Sun, Jin Sun   +8 more
wiley   +1 more source