Results 41 to 50 of about 384,141 (378)
CancerMine: a literature-mined resource for drivers, oncogenes and tumor suppressors in cancer
Nature Methods, 2018 Tumors from individuals with cancer are frequently genetically profiled for information about the driving forces behind the disease. We present the CancerMine resource, a text-mined and routinely updated database of drivers, oncogenes and tumor ...
Jake Lever +4 more
semanticscholar +1 more source
Molecular Mechanisms Underlying Hepatocellular Carcinoma
Viruses, 2009 Hepatocarcinogenesis is a complex process that remains still partly understood. That might be explained by the multiplicity of etiologic factors, the genetic/epigenetic heterogeneity of tumors bulks and the ignorance of the liver cell types that give ...
Christian Trepo, Philippe Merle
doaj +1 more source
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. [PDF]
, 2020 The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is ...
Coon, Joshua +5 more
core
International Journal of Molecular Sciences, 2018 Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 ...
N. S. Yeo-Teh, Yoshiaki Ito, S. Jha
semanticscholar +1 more source
The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus
Dental Research Journal, 2023 Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with heterogeneous molecular pathogenesis. Oral lichen planus (OLP) is demonstrated potentially can transfer to OSCC malignant lesions.
Ensieh Sagheb Sadeghi +3 more
doaj +1 more source
Protein transduction: A novel tool for tissue regeneration [PDF]
, 2002 Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W. +4 more
core +1 more source
Nature Communications, 2018 Epigenetic modifications such as aberrant DNA methylation reshape the gene expression repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) mouse model (Alb-R26Met) to explore the impact of DNA methylation on ...
María Arechederra +8 more
semanticscholar +1 more source
Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies [PDF]
, 2019 In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies.
Berx, Geert +16 more
core +2 more sources
Change in Polycythemia Vera Treatment: Ropeginterferon Alfa-2b in Light of Current Trials
Turkish Journal of Hematology, 2023 Ropeginterferon alfa-2b (RopegIFN) enables effective cytoreduction in polycythemia vera (PV). Recent analyses suggest that long-term RopegIFN therapy fulfills treatment goals important to patients with PV including good quality of life, the slowing of ...
Heinz Gisslinger
doaj +1 more source
Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment
Frontiers in Cell and Developmental Biology, 2018 Historically, the link between chronic inflammation and cancer has long been speculated. Only more recently, pre-clinical and epidemiologic data as well as clinical evidence all point to the role of the tumor microenvironment as inextricably connected to
Elizabeth A. Comen +4 more
doaj +1 more source