Results 41 to 50 of about 250,918 (350)
EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer
Molecular Cancer, 2017 Background Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types.
Jiqin Zhang +13 more
doaj +1 more source
Change in Polycythemia Vera Treatment: Ropeginterferon Alfa-2b in Light of Current Trials
Turkish Journal of Hematology, 2023 Ropeginterferon alfa-2b (RopegIFN) enables effective cytoreduction in polycythemia vera (PV). Recent analyses suggest that long-term RopegIFN therapy fulfills treatment goals important to patients with PV including good quality of life, the slowing of ...
Heinz Gisslinger
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Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene Expression
Veterinary Sciences, 2015 Breast cancer represents the second most frequent neoplasm in humans and sexually intact female dogs after lung and skin cancers, respectively. Many similar features in human and dog cancers including, spontaneous development, clinical presentation ...
Farruk M. Lutful Kabir +2 more
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Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. [PDF]
, 2020 The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is ...
Coon, Joshua +5 more
core
Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis
Frontiers in Oncology, 2018 Metabolic reprogramming confers cancer cells the ability to grow and survive under nutrient-depleted or stressful microenvironments. The amplification of oncogenes, the loss of tumor suppressors, as well as context- and lineage-specific determinants can ...
Simon-Pierre Gravel
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Biomedicines, 2021 Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease caused in 10% of cases by inherited mutations considered “familial”. An ever-increasing amount of evidence is showing a fundamental role for RNA metabolism in ALS pathogenesis,
Federica Rey +8 more
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RNF4-Dependent Oncogene Activation by Protein Stabilization
Cell Reports, 2016 Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β ...
Jane J. Thomas +13 more
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Cells, 2021 Ever since the ubiquitin proteasome system was characterized, efforts have been made to manipulate its function to abrogate the progression of cancer. As a result, the anti-cancer drugs bortezomib, carfilzomib, and ixazomib targeting the 26S proteasome ...
Andres J. Rubio +6 more
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Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies [PDF]
, 2019 In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies.
Berx, Geert +16 more
core +2 more sources
Molecular Cancer, 2003 Background Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor suppressor genes via mechanisms involving the glucocorticoid receptor.
Badr Mostafa Z, Youssef Jihan A
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