Results 61 to 70 of about 250,918 (350)

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. [PDF]

, 2017
Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types.
Balanis, Nikolas G, Beck, Lillie, Braas, Daniel, Cass, Ashley, Chan, Shawna, Christofk, Heather R, Delgado, Adrian, Friedman, Michael, Go, James, Graeber, Thomas G, Graham, Nicholas A, Hurtz, Christian, Larson, Steven M, Lomova, Anastasia, Mellinghoff, Ingo K, Minasyan, Aspram, Multani, Asha S, Müschen, Markus, Ng, Carina, Palaskas, Nicolaos, Port, Elisa, Qiao, Rong, Schultz, Nikolaus, Ten Hoeve, Johanna, Wu, Hong, Zhao, Sophie   +25 more
core   +3 more sources

Molecular Mechanisms Underlying Hepatocellular Carcinoma

Viruses, 2009
Hepatocarcinogenesis is a complex process that remains still partly understood. That might be explained by the multiplicity of etiologic factors, the genetic/epigenetic heterogeneity of tumors bulks and the ignorance of the liver cell types that give ...
Christian Trepo, Philippe Merle
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

TMEM Proteins in Cancer: A Review

Frontiers in Pharmacology, 2018
A transmembrane protein (TMEM) is a type of protein that spans biological membranes. Many of them extend through the lipid bilayer of the plasma membrane but others are located to the membrane of organelles.
Kathleen Schmit, Carine Michiels
doaj   +1 more source

The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review

Global Medical Genetics, 2023
Matrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial diseases ...
Datis Kalali
doaj   +1 more source

A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes [PDF]

, 2010
The influence of DNA cis-regulatory elements on a gene's expression has been intensively studied. However, little is known about expressions driven by trans-acting DNA hotspots. DNA hotspots harboring copy number aberrations are recognized to be important in cancer as they influence multiple genes on a global scale.
arxiv   +1 more source

MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors [PDF]

, 2012
BACKGROUND MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with pre-malignant pancreatic tumors.
A Cimmino, A Grimson, A Keller, A Lal, A Singh, Adam E. Frampton, AE Szafranska, AE Szafranska, AL Warshaw, AM Bellizzi, AM Krichevsky, AN Bartley, Andreas Keller, BM Bolstad, C Almoguera, C Galanis, C Mayr, C Stefano, D Bartsch, D Bonci, DS Klimstra, DV Sahani, F Takeshita, FA Sinicrope, G Garcea, GA Calin, Georgios Giamas, GK Smyth, GK Smyth, H Matthaei, H Wang, J Lu, J Meister, J Torrisani, J Yu, Jimmy Jacob, Jonathan Krell, JS Desgrosellier, JS Oh, Justin Stebbing, K Izeradjene, K Ohuchida, K Satoh, K Yoshizawa, KC Miranda, L Castellano, L Xia, Leandro Castellano, Long R. Jiao, Loredana Pellegrino, M Bloomston, M Crawford, M Dillhoff, M Fabbri, M Goggins, M Seux, M Tanaka, Marc Tjwa, MC du Rieu, N Abe, N Habbe, Nagy A. Habib, Nicole Tsim, O Basturk, OA Kent, Panagiotis Vlavianos, Patrizia Cohen, R Bhattacharya, R Feng, Raida Ahmad, RI Aqeilan, S Griffiths-Jones, S Griffiths-Jones, S Hamada, S Mukherjee, S Reddy, S Vorwerk, S Watanabe, S Yu, SD Selcuklu, SF Tavazoie, SM Johnson, SYG Friedlander, T Ishikawa, T Paranjape, WA Mardin, WG Zhao, WR Brugge, X Chen, X Li, Y Akao, Y Benjamini, Y Hochberg, YJ Chua   +93 more
core   +4 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Proto‐oncogenes and oncogenes in epidermal neoplasia [PDF]

Experimental Dermatology, 1995
Abstract This review briefly will focus on the role of selected proto‐onco‐genes and their activated forms during the regulation of cell proliferation, cell death and tumor formation in the epidermis. In addition, the multiple and complex functions of these proteins in normal as well as transformed cells will be discussed.
G. Sliutz, M. M. Simon, T. A. Luger
openaire   +3 more sources

Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment

Frontiers in Cell and Developmental Biology, 2018
Historically, the link between chronic inflammation and cancer has long been speculated. Only more recently, pre-clinical and epidemiologic data as well as clinical evidence all point to the role of the tumor microenvironment as inextricably connected to
Elizabeth A. Comen, Robert L. Bowman, Robert L. Bowman, Maria Kleppe, Maria Kleppe   +4 more
doaj   +1 more source