Results 191 to 200 of about 80,296 (266)

Chondroid Soft Tissue Tumors With FOS::PABPN1 Fusion: A New Entity? About Two Cases

Genes, Chromosomes and Cancer, Volume 65, Issue 8, August 2026.
ABSTRACT Soft tissue tumors with chondroid matrix represent a heterogeneous group with persistent diagnostic challenges. Advances in molecular diagnostics have identified recurrent gene fusions in several chondroid neoplasms, predominantly involving FN1. Here, we report two cases of chondroid tumors harboring a novel FOS::PABPN1 fusion.
Jinane Kharmoum, Alexendra Meurgey, Daniel pissaloux, Sanae Chaib, Nicolas Macagno, Mariame Chraibi, Franck Tirode, Marie Karanian   +7 more
wiley   +1 more source

AI-Guided Discovery of Oncogenic Signaling Crosstalk in Tumor Progression and Drug Resistance. [PDF]

Oncol Res
Sutanto E, Sutanto R, Velichkovikj S, Hadzi-Petrushev N, Mladenov M, Avtanski D, Stojchevski R.   +6 more
europepmc   +1 more source

ELAVL1 Promotes Proliferation and Inhibits Apoptosis of the Marek's Disease Virus (MDV)-Transformed Cell Line MSB1 via the COX-2/PGE2 Pathway. [PDF]

Animals (Basel)
He L, Zhan DM, Peng H, Gao MR, Chen J, Jia YY, Liao CS, Chen SB, Ding K, Yu ZH.   +9 more
europepmc   +1 more source

Targeted Interventions in HAM/TSP: Emerging Therapies and Future Directions – A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.
Meygol Mirzaei Rezaei, Mahdi Khosravi Nia, Kasra Allaei Rouzbahani, Maryam Kazemi, Negar Asghari Hosori, Mehdi Norouzi, Farzaneh Sotoudegan, Narges Eslami, Negar Ariamand, Vahid Shahnavaz, Arash Letafati, Sayed‑Hamidreza Mozhgani   +11 more
wiley   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Salivary miR-34a Exhibits State-Dependent Dysregulation Across Normal Oral Mucosa, Premalignant Lesions and Oral Squamous Cell Carcinoma. [PDF]

Genes (Basel)
Gintoni I, Vassiliou S, Kardara Bellou M, Balakas A, Lefantzis N, Papakosta V, Chrousos GP, Yapijakis C.   +7 more
europepmc   +1 more source

USP1 Promotes Malignant Progression of Cervical Cancer Cells by Deubiquitinating and Stabilizing ATG13 to Enhance Autophagic Activity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
USP1, overexpressed in cervical cancer and linked to advanced pathological grade, promotes cervical cancer progression by deubiquitinating and stabilizing ATG13 to enhance autophagy, and USP1 inhibitor ML323 can reverse this oncogenic effect, making USP1 a promising therapeutic target for cervical cancer.
Chunyan Liu, Zhitong Liu, Changyan Dong, Xiaona Jiang, Xiao Chen   +4 more
wiley   +1 more source

The role of gut microbiota and its metabolites in preventing oncogenesis. [PDF]

Front Cell Dev Biol
Li Z, Yan J, Zeng Z, Zhao L.
europepmc   +1 more source

Elucidating the Mechanisms of Trichloroethylene‐Induced Kidney Cancer: Network Toxicology, Molecular Docking, and In Vitro Validation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
An integrated network toxicology, molecular docking, and in vitro validation approach was applied to identify TP53, ACTB, and CASP3 as key targets mediating trichloroethylene‐driven kidney carcinogenesis via aberrant signaling regulation. ABSTRACT Trichloroethylene (TCE), a pervasive environmental contaminant, is epidemiologically linked to kidney, but
Weijie Ma, Hui Cai
wiley   +1 more source