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Annals of Hepatology, 2008 Current oncolytic virotherapy strategies are based in the accumulated understanding of the common molecular mechanisms displayed during cell transformation and viral infection, like cell cycle and apoptosis deregulations.
Daniel Cervantes-García; +3 more
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Syncytia Formation in Oncolytic Virotherapy [PDF]
Molecular Therapy: Oncolytics, 2019 Oncolytic virotherapy uses replication-competent virus as a means of treating cancer. Whereas this field has shown great promise as a viable treatment method, the limited spread of these viruses throughout the tumor microenvironment remains a major ...
Chase Burton, Eric Bartee
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Vesicular Stomatitis Virus-Based Oncolytic Virotherapy: Recent Progress and Emerging Trends [PDF]
Current OncologyOncolytic virotherapy has emerged as a promising and innovative approach to cancer treatment, leveraging viruses that selectively replicate in tumor cells and cause their destruction (oncolysis), while simultaneously stimulating anti-tumor immune ...
Cassandra Catacalos-Goad +2 more
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Comparative safety and efficacy of oncolytic virotherapy for the treatment of individuals with malignancies: a systematic review, meta-analysis, and Bayesian network meta-analysisResearch in context [PDF]
EClinicalMedicineSummary: Background: Oncolytic virotherapy (OV) is an innovative immunotherapy strategy. A comprehensive understanding of oncolytic viruses is essential for advancing research and clinical practice.
Poyee Lau +4 more
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The 16th international oncolytic virotherapy conference: from in vitro to clinical studies, novel approaches in cancer therapy meeting report [PDF]
Frontiers in ImmunologyThe 16th International Oncolytic Virotherapy Conference, which was held in the vibrant city of Rotterdam, Netherlands, on 27-30th November 2024, featured a variety of novel strategies for improving oncolytic virus therapy.
Elena Ekrami +4 more
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The combination therapy of oncolytic virotherapy. [PDF]
Front PharmacolIntroduction: Compared to other cancer immunotherapies, oncolytic viruses possess several advantages, including high killing efficiency, excellent targeting capabilities, minimal adverse reactions, and multiple pathways for tumor destruction. However, the efficacy of oncolytic viruses as a monotherapy often falls short of expectations.
Wang Y, Zhu M, Chi H, Liu Y, Yu G.
europepmc +4 more sources
Nature Biotechnology, 2012 Oncolytic virotherapy is an emerging treatment modality that uses replication-competent viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a single-shot virotherapy cure, identification of drugs that accelerate intratumoral virus propagation, strategies to maximize the immunotherapeutic action of oncolytic viruses ...
Russell, Stephen J +2 more
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Current strategies in engaging oncolytic viruses with antitumor immunity
Molecular Therapy: Oncolytics, 2021 Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni +2 more
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Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
Journal of Hematology & Oncology, 2021 Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far ...
Johannes P. W. Heidbuechel +1 more
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Lung cancer and oncolytic virotherapy——enemy's enemy
Translational Oncology, 2023 Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li +3 more
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