Results 1 to 10 of about 28,421 (276)

Syncytia Formation in Oncolytic Virotherapy [PDF]

Molecular Therapy: Oncolytics, 2019
Oncolytic virotherapy uses replication-competent virus as a means of treating cancer. Whereas this field has shown great promise as a viable treatment method, the limited spread of these viruses throughout the tumor microenvironment remains a major ...
Chase Burton, Eric Bartee
doaj   +5 more sources

The combination therapy of oncolytic virotherapy. [PDF]

Front Pharmacol
Introduction: Compared to other cancer immunotherapies, oncolytic viruses possess several advantages, including high killing efficiency, excellent targeting capabilities, minimal adverse reactions, and multiple pathways for tumor destruction.
Wang Y, Zhu M, Chi H, Liu Y, Yu G.
europepmc   +5 more sources

Strategies for Advanced Oncolytic Virotherapy: Current Technology Innovations and Clinical Approaches

Pharmaceutics, 2022
Oncolytic virotherapy is a type of nanomedicine with a dual antitumor mechanism. Viruses are engineered to selectively infect and lyse cancer cells directly, leading to the release of soluble antigens which induce systemic antitumor immunity ...
Qing Ji, Yuchen Wu, Andreas Albers, Meiyu Fang, Xu Qian   +4 more
doaj   +2 more sources

Oncolytic Virotherapy for High-Grade Glioma and Current Evidence and Factors to Consider for Incorporation into Clinical Practice

Pathogens, 2023
Brain tumor incidence is on the rise, and glioblastoma comprises the majority of primary tumors. Despite maximal safe resection and adjuvant chemoradiation, median survival for high-grade glioma remains poor.
Sauson Soldozy, Daniel G. Eichberg, Alexis A. Morell, Evan Luther, Victor M. Lu, Dominique M. O. Higgins, Nitesh V. Patel, Ashish H. Shah, Simon J. Hanft, Ricardo J. Komotar, Michael E. Ivan   +10 more
doaj   +2 more sources

Delivery and Biosafety of Oncolytic Virotherapy

Frontiers in Oncology, 2020
In recent years, oncolytic virotherapy has emerged as a promising anticancer therapy. Oncolytic viruses destroy cancer cells, without damaging normal tissues, through virus self-replication and antitumor immunity responses, showing great potential for ...
Lizhi Li, Lizhi Li, Shixin Liu, Shixin Liu, Duoduo Han, Duoduo Han, Bin Tang, Bin Tang, Jian Ma, Jian Ma, Jian Ma   +10 more
doaj   +2 more sources

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

Nature Communications
Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with cancer progression, yet their formation mechanism and role in oncolytic
Weiwei Dai, Ruotong Tian, Liubing Yu, Shasha Bian, Yuling Chen, Bowen Yin, Yuxuan Luan, Siqi Chen, Zhuoyang Fan, Rucheng Yan, Xin Pan, Yingyong Hou, Rong Li, Juxiang Chen, Minfeng Shu   +14 more
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Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma. [PDF]

Nat Commun
Oncolytic viruses (OVs) hold promise for cancer treatment. However, the antitumor efficacy is limited. Microbiota plays a pivotal role in cancer treatment and its impact on oncolytic virotherapy is unknown.
Zhang J, Yang J, Luo J, Wu W, Luo H, Wei W, Lyu H, Wang Y, Yi H, Zhang Y, Fan Z, Lyu H, Kanakaveti VP, Qin B, Yuan P, Yang R, Zhang H, Zuo T, Felsher DW, Lee MH, Li K.   +20 more
europepmc   +2 more sources

Vesicular Stomatitis Virus-Based Oncolytic Virotherapy: Recent Progress and Emerging Trends [PDF]

Current Oncology
Oncolytic virotherapy has emerged as a promising and innovative approach to cancer treatment, leveraging viruses that selectively replicate in tumor cells and cause their destruction (oncolysis), while simultaneously stimulating anti-tumor immune ...
Cassandra Catacalos-Goad, Charlotte Johnstone, Valery Z. Grdzelishvili   +2 more
doaj   +2 more sources

Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity [PDF]

Nature Communications, 2022
Immunotherapies directly enhancing anti-tumor CD8^+ T cell responses have yielded measurable but limited success, highlighting the need for alternatives.
J. Svensson-Arvelund, Sara Cuadrado-Castano, Gvantsa Pantsulaia, Kristy Kim, Mark Aleynick, L. Hammerich, R. Upadhyay, M. Yellin, H. Marsh, Daniel Oreper, S. Jhunjhunwala, C. Moussion, M. Merad, Brian D. Brown, A. García-Sastre, J. Brody   +15 more
semanticscholar   +2 more sources

Tumor dynamics model with treatments by oncolytic virotherapy and MEK inhibitors involving TNF-α inhibitors: Stability analysis and optimal control

Computational and Mathematical Biophysics
Oncolytic virotherapy is one of the cancer treatments that kills cancer cells but leaves normal cells. Furthermore, mitogen-activated protein kinase (MEK) inhibitors boost chimeric antigen receptor expression and increase oncolytic virus entry into tumor
Daengkongkho Salinthip, Viriyapong Ratchada   +1 more
doaj   +2 more sources