Results 31 to 40 of about 18,621 (199)
Personalizing Oncolytic Virotherapy?
Molecular Therapy, 2007 raditionally, cancer therapies have been based on the empiric discovery of drugs and/or biological agents that act selectively against tumor cells. Recently, however, a generation of rationally discov-ered drugs and agents has been developed that shows encouraging benefi t in treating cancers.
Kaur, Balveen, Chiocca, E Antonio
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Oncolytic polio virotherapy of cancer [PDF]
Cancer, 2014 Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
Michael C, Brown +12 more
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Implications of MicroRNAs in Oncolytic Virotherapy [PDF]
Frontiers in Oncology, 2017 MicroRNAs (miRNAs) are an abundant class of small non-coding RNA molecules (~22 nt) that can repress gene expression. Deregulation of certain miRNAs is widely recognized as a robust biomarker for many neoplasms, as well as an important player in tumorigenesis and the establishment of tumoral microenvironments.
Xavier Bofill-De Ros +5 more
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Development of a WNT-selective oncolytic adenovirus for imaging the therapy of colorectal cancers. [PDF]
, 2008 PhDIntroduction: The concept of oncolytic adenoviruses has been validated in preclinical studies but clinical trials have demonstrated that the virus spread remains limited and the virus fails to infect all cancer cells in a tumour.
Peerlinck, Inge D. L.
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Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages
Journal of Translational Medicine, 2023 Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host immune response are irreplaceable advantages of cancer immunotherapy.
Zhen Shen +7 more
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Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances [PDF]
, 2016 Oncolytic viruses are multifunctional anticancer agents with huge clinical potential, and have recently passed the randomized Phase III clinical trial hurdle.
Relph, KL +4 more
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The role of autophagy in neoplastic cell response to oncolytic viruses [PDF]
, 2009 Oncolytic conditionally replicating adenoviruses (CRAds) are viral mutants able to selectively replicate in tumour cells. CRAds are considered a promising platform for cancer therapy. dl922-947, bearing a mutation in E1A gene and AdΔΔ, carrying mutations
Botta, Ginevra
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Tumor Restrictions to Oncolytic Virus
Biomedicines, 2014 Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models.
Markus Vähä-Koskela, Ari Hinkkanen
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The Role of Neutrophils in Oncolytic Orf Virus-Mediated Cancer Immunotherapy
Cells, 2022 Neutrophils are innate leukocytes with diverse effector functions that allow them to respond to pathogens rapidly. Accumulating evidence has highlighted these cells’ complex roles in the host’s response to viral infections and tumor progression ...
Jessica A. Minott +5 more
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Viruses, 2015 Oncolytic virotherapy for cancer is an innovative therapeutic option where the ability of a virus to promote cell lysis is harnessed and reprogrammed to selectively destroy cancer cells.
Janice Kim +3 more
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