Results 21 to 30 of about 8,958 (210)
Viruses, 2015 Oncolytic virotherapy for cancer is an innovative therapeutic option where the ability of a virus to promote cell lysis is harnessed and reprogrammed to selectively destroy cancer cells.
Janice Kim +3 more
doaj +2 more sources
Frontiers in ImmunologyThe 16th International Oncolytic Virotherapy Conference, which was held in the vibrant city of Rotterdam, Netherlands, on 27-30th November 2024, featured a variety of novel strategies for improving oncolytic virus therapy.
Elena Ekrami +4 more
doaj +2 more sources
Nature Biotechnology, 2012 Oncolytic virotherapy is an emerging treatment modality that uses replication-competent viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a single-shot virotherapy cure, identification of drugs that accelerate intratumoral virus propagation, strategies to maximize the immunotherapeutic action of oncolytic viruses ...
Russell, Stephen J +2 more
openaire +3 more sources
Current strategies in engaging oncolytic viruses with antitumor immunity
Molecular Therapy: Oncolytics, 2021 Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni +2 more
doaj +1 more source
Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
Journal of Hematology & Oncology, 2021 Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far ...
Johannes P. W. Heidbuechel +1 more
doaj +1 more source
Lung cancer and oncolytic virotherapy——enemy's enemy
Translational Oncology, 2023 Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li +3 more
doaj +1 more source
Advances in oncolytic virotherapy
Communications Medicine, 2022 Recent years have seen rapid advances in the preclinical development and clinical evaluation of oncolytic (cancer-lysing) virus-based therapies, and these are emerging as treatment modality for some cancers. There are challenges to address, however, if we are to maximize the impact of these therapies in patients.
Stephen J. Russell +3 more
openaire +3 more sources
Personalizing Oncolytic Virotherapy
Human Gene Therapy, 2023 The use of oncolytic viruses has become an attractive tool in the clinics for the treatment of various tumor types. Such viruses are genetically modified to conditionally replicate in malignant cells while unharming healthy cells. This platform offers a highly specific tumor killing with exceptional safety profiles.
Firas Hamdan +2 more
openaire +4 more sources
Molecular Therapy: Oncolytics, 2022 Oncolytic virotherapies have shown excellent promise in a variety of cancers by promoting antitumor immunity. However, the effects of oncolytic virus-mediated type I interferon (IFN-I) production on antitumor immunity remain unclear.
Nader El-Sayes +6 more
doaj +1 more source
Cancer Cell International, 2022 Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity.
Sara Shayan +2 more
doaj +1 more source