Results 21 to 30 of about 18,621 (199)

Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?

Molecular Therapy: Oncolytics, 2022
Oncolytic viruses are designed to specifically target cancer cells, sparing normal cells. Although numerous studies demonstrate the ability of oncolytic viruses to infect a wide range of non-tumor cells, the significance of this phenomenon for cancer ...
Victor A. Naumenko, Aleksei A. Stepanenko, Anastasiia V. Lipatova, Daniil A. Vishnevskiy, Vladimir P. Chekhonin   +4 more
doaj   +1 more source

Oncolytic virus delivery: from nano-pharmacodynamics to enhanced oncolytic effect [PDF]

, 2017
: With the advancement of a growing number of oncolytic viruses (OVs) to clinical development, drug delivery is becoming an important barrier to overcome for optimal therapeutic benefits.

core   +1 more source

Single-cell RNA sequencing reveals a strong connection between Gadd45g upregulation and oncolytic HSV infection in tumor tissue

Molecular Therapy: Oncolytics, 2021
The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang   +3 more
doaj   +1 more source

Oncolytic Viruses for Cancer Therapy: Barriers and Recent Advances

Molecular Therapy: Oncolytics, 2019
Oncolytic viruses (OVs) are powerful new therapeutic agents in cancer therapy. With the first OV (talimogene laherparepvec [T-vec]) obtaining US Food and Drug Administration approval, interest in OVs has been boosted greatly.
Meijun Zheng, Jianhan Huang, Aiping Tong, Hui Yang   +3 more
doaj   +1 more source

A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report

SAGE Open Medical Case Reports, 2020
Melanoma is an aggressive skin cancer form with a grave prognosis. Current results suggest that oncolytic virus treatment of melanoma has a high therapeutic potential. ECHO-7 (Rigvir) is the first oncolytic virus registered in Latvia.
Vladimirs Sorokins, Andra Tilgase, Evija Olmane, Sergejs Isajevs, Tatjana Zablocka, Agnija Rasa, Pēteris Alberts   +6 more
doaj   +1 more source

Oncolytic Virotherapy for High-Grade Glioma and Current Evidence and Factors to Consider for Incorporation into Clinical Practice

Pathogens, 2023
Brain tumor incidence is on the rise, and glioblastoma comprises the majority of primary tumors. Despite maximal safe resection and adjuvant chemoradiation, median survival for high-grade glioma remains poor.
Sauson Soldozy, Daniel G. Eichberg, Alexis A. Morell, Evan Luther, Victor M. Lu, Dominique M. O. Higgins, Nitesh V. Patel, Ashish H. Shah, Simon J. Hanft, Ricardo J. Komotar, Michael E. Ivan   +10 more
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Progress of oncolytic virotherapy for neuroblastoma

Frontiers in Pediatrics, 2022
As a neuroendocrine tumor derived from the neural crest, neuroblastoma (NB) is the most common extracranial solid tumor in children. The prognosis in patients with low- and intermediate-risk NB is favorable while that in high-risk patients is often detrimental.
Xiao-Tong Chen, Shu-Yang Dai, Yong Zhan, Ran Yang, De-Qian Chen, Yi Li, En-Qing Zhou, Rui Dong   +7 more
openaire   +3 more sources

Tropism and transduction of oncolytic adenovirus vectors in prostate cancer therapy

Frontiers in Bioscience-Landmark, 2021
Oncolytic adenovirus has been applied in cancer therapy because of several advantages such as cost-effective production, high transduction efficiency and low toxicity.
Chuang Wu, Fu-kun Wei, Zi-yang Xu, Ru-min Wen, Jia-cun Chen, Jun-qi Wang, Li-jun Mao   +6 more
doaj   +1 more source

Oncolytic virotherapy for pancreatic cancer [PDF]

Expert Reviews in Molecular Medicine, 2011
Within the past decade, many oncolytic viruses (OVs) have been studied as potential treatments for pancreatic cancer and some of these are currently under clinical trials. The applicability of certain OVs, such as adenoviruses, herpesviruses and reoviruses, for the treatment of pancreatic cancer has been intensively studied for several years, whereas ...
Sonia, Wennier, Shoudong, Li, Grant, McFadden   +2 more
openaire   +2 more sources

Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy

Molecular Cancer, 2020
As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for conditional-replication within carcinoma cells leading to cell death via
Bin Zhang, Ping Cheng
doaj   +1 more source