Results 41 to 50 of about 12,104 (196)

Oncolytic Virotherapy in Glioma Tumors [PDF]

International Journal of Molecular Sciences, 2020
Glioma tumors are one of the most devastating cancer types. Glioblastoma is the most advanced stage with the worst prognosis. Current therapies are still unable to provide an effective cure. Recent advances in oncolytic immunotherapy have generated great expectations in the cancer therapy field. The use of oncolytic viruses (OVs) in cancer treatment is
Sergio Rius-Rocabert, Noemí García-Romero, Antonia García, Angel Ayuso-Sacido, Estanislao Nistal-Villan   +4 more
openaire   +3 more sources

Sorting Out Pandora’s Box: Discerning the Dynamic Roles of Liver Microenvironment in Oncolytic Virus Therapy for Hepatocellular Carcinoma [PDF]

, 2014
Oncolytic viral therapies have recently found their way into clinical application for hepatocellular carcinoma (HCC), a disease with limited treatment options and poor prognosis. Adding to the many intrinsic challenges of in vivo oncolytic viral therapy,
Jennifer Altomonte, Oliver Ebert
core   +3 more sources

The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma [PDF]

, 2015
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and current treatments are ineffective in increasing patients' survival. Thus, the development of new therapeutic approaches for ATC is needed.
Ayyoub, Baeuerle, Bell, Bell, Bell, Benveniste, Bonecchi, Burgert, Chariot, Chieffi, Cobb, Coussens, Curti, Di Cristofano, Dupuy, Fagin, Fernando, Feuerer, Fidler, Fong, Fueyo, Ghosh, Giordano, Guo, Hallden, Hallden, Hanahan, Haugen, Haugen, Hickman, Horwitz, Horwitz, Iwasaki, Kairemo, Karin, Kirn, Kirn, Kracht, Leonardi, Maeda, Mameli, Mantovani, Mantovani, Mantovani, Matsuno, McCart, McKiernan, Melcher, Melillo, Nemunaitis, Okubo, Pinchera, Pollard, Portella, Portella, Portella, Portella, Portella, Portella, Portella, Rabkin, Remick, Ribatti, Rice, Schmittgen, Sheridan, Syed, Tanaka, Udelsman, Vilcek, Weinberg, Wilson   +71 more
core   +2 more sources

A Novel Molecular Therapy Using Bioengineered Adenovirus for Human Gastrointestinal Cancer [PDF]

, 2011
Replication-selective tumor-specific viruses constitute a novel approach for treatment of neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells after selective viral propagation within the tumor. Human telomerase is
Fujiwara, Toshiyoshi
core   +1 more source

Oncolytic polio virotherapy of cancer [PDF]

Cancer, 2014
Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
Michael C, Brown, Elena Y, Dobrikova, Mikhail I, Dobrikov, Ross W, Walton, Sarah L, Gemberling, Smita K, Nair, Annick, Desjardins, John H, Sampson, Henry S, Friedman, Allan H, Friedman, Douglas S, Tyler, Darell D, Bigner, Matthias, Gromeier   +12 more
openaire   +2 more sources

Oncolytic Virotherapy for Cancer: Clinical Experience [PDF]

Biomedicines, 2021
Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and virology have renewed the interest in using viruses as oncolytic agents.
Shyambabu Chaurasiya, Yuman Fong, Susanne G. Warner   +2 more
openaire   +3 more sources

Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages

Journal of Translational Medicine, 2023
Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host immune response are irreplaceable advantages of cancer immunotherapy.
Zhen Shen, Xiyu Liu, Guixiang Fan, Jintong Na, Qiaoqiao Liu, Faquan Lin, Zhikun Zhang, Liping Zhong   +7 more
doaj   +1 more source

Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma [PDF]

, 2010
A fully intact immune system would be expected to hinder the efficacy of oncolytic virotherapy by inhibiting viral replication. Simultaneously, however, it may also enhance antitumor therapy through initiation of proinflammatory, antiviral cytokine ...
Barber, G, Diaz, RM, Galivo, F, Kottke, T, Melcher, A, Thompson, J, Vile, R, Wongthida, P   +7 more
core   +1 more source

The Role of Neutrophils in Oncolytic Orf Virus-Mediated Cancer Immunotherapy

Cells, 2022
Neutrophils are innate leukocytes with diverse effector functions that allow them to respond to pathogens rapidly. Accumulating evidence has highlighted these cells’ complex roles in the host’s response to viral infections and tumor progression ...
Jessica A. Minott, Jacob P. van Vloten, Lily Chan, Yeganeh Mehrani, Byram W. Bridle, Khalil Karimi   +5 more
doaj   +1 more source

Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

, 2013
Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C, Martins, Marcelo L, Paiva, Leticia R, Silva, Hallan S   +3 more
core   +2 more sources