Results 61 to 70 of about 12,104 (196)

Oncolytic virotherapy – Forging its place in the immunomodulatory paradigm for Multiple Myeloma

Cancer Treatment and Research Communications, 2021
The treatment focus for multiple myeloma (MM) has recently pivoted towards immune modulating strategies, with T-cell redirection therapies currently at the forefront of drug development.
Joselle Cook, MD, Aldo A. Acosta-Medina, MD, Kah Whye Peng, PhD, Martha Lacy, MD, Stephen Russell, MD, PhD   +4 more
doaj   +1 more source

HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy [PDF]

, 2014
Several clinical trials have shown that oncolytic herpes simplex virus type 1 (oHSV-1) can be safely administered to patients. However, virus replication in tumor tissue has generally not been monitored in these oHSV clinical trials, and the data suggest
Decklever, T D, Li, H, Nace, R A, Nakashima, H, Russell, S J   +4 more
core   +1 more source

Oncolytic Virotherapy for Hematological Malignancies [PDF]

Advances in Virology, 2012
Hematological malignancies such as leukemias, lymphomas, multiple myeloma (MM), and the myelodysplastic syndromes (MDSs) primarily affect adults and are difficult to treat. For high-risk disease, hematopoietic stem cell transplant (HCT) can be used. However, in the setting of autologous HCT, relapse due to contamination of the autograft with cancer ...
Swarna Bais, Eric Bartee, Masmudur M. Rahman, Grant McFadden, Christopher R. Cogle   +4 more
openaire   +3 more sources

Intravenous Injections of a Rationally Selected Oncolytic Herpes Virus as a Potent Virotherapy for Hepatocellular Carcinoma

Molecular Therapy: Oncolytics, 2019
As a clinical setting in which novel treatment options are urgently needed, hepatocellular carcinoma (HCC) exhibits intriguing opportunities for oncolytic virotherapy.
Yong Luo, Chaolong Lin, Wenfeng Ren, Fei Ju, Zilong Xu, Huiling Liu, Zeng Yu, Jun Chen, Jun Zhang, Pingguo Liu, Chenghao Huang, Ningshao Xia   +11 more
doaj   +1 more source

Reprogramming the tumor microenvironment leverages CD8+ T cell responses to a shared tumor/self antigen in ovarian cancer

Molecular Therapy: Oncolytics, 2023
Tumor antigen-driven responses to weakly immunogenic self-antigens and neoantigens directly affect treatment efficacy following immunotherapy. Using orthotopically grown SV40 T antigen+ ovarian carcinoma in antigen-naive wild-type or TgMISIIR-TAg-Low ...
Anna Mistarz, Marta Winkler, Sebastiano Battaglia, Song Liu, Alan Hutson, Hanna Rokita, Andrea Gambotto, Kunle O. Odunsi, Prashant K. Singh, A.J. Robert McGray, Jianmin Wang, Danuta Kozbor   +11 more
doaj   +1 more source

Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice [PDF]

, 2008
BACKGROUND: The NV1020 oncolytic herpes simplex virus type-1 has shown significant promise for the treatment of many different types of tumors in experimental animal models and human trials. Previously, we described the construction and use of the NV1020-
Israyelyan, Anna, Chouljenko, Vladimir N, Baghian, Abolghasem, David, Andrew T, Kearney, Michael T, Kousoulas, Konstantin G   +5 more
core   +2 more sources

Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core  

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion [PDF]

, 2017
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumours with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms ...
Bartolini, Caretti, Cockle, Cockle, Demuth, Dumontet, Etienne-Manneville, Etienne-Manneville, Etienne-Manneville, Fangusaro, Ganguly, Grimes, Hargrave, Harrow, Jones, Kaufman, Khatua, Kirschner, Liao, Louis, Louis, Luo, Lyman, Naghavi, Papanastassiou, Peris, Prestwich, Radtke, Rampling, Reed, Russell, Schroeder, Schulze, Sun, Taylor, Tran, Turnbull, Waterman-Storer, Wollmann   +38 more
core   +3 more sources

Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis

Scientific Reports, 2021
Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem ...
Amanda W. K. AuYeung, Robert C. Mould, Ashley A. Stegelmeier, Jacob P. van Vloten, Khalil Karimi, J. Paul Woods, James J. Petrik, Geoffrey A. Wood, Byram W. Bridle   +8 more
doaj   +1 more source

The essential role of mitochondrial dynamics in antiviral immunity. [PDF]

, 2018
Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun, Kim, Seong-Jun, Siddiqui, Aleem, Syed, Gulam H   +3 more
core   +2 more sources