Results 71 to 80 of about 8,958 (210)
Scientific Reports, 2021 Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem ...
Amanda W. K. AuYeung +8 more
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Current landscape and perspective of oncolytic viruses and their combination therapies
Translational Oncology, 2022 Oncolytic virotherapy has become an important strategy in cancer immunotherapy. Oncolytic virus (OV) can reshape the tumor microenvironment (TME) through its replication-mediated oncolysis and transgene-produced anticancer effect, inducing an antitumor ...
Yinghan Su, Changqing Su, Lunxiu Qin
doaj +1 more source
Cancer Science, EarlyView.OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan +8 more
wiley +1 more source
Oncolytic virotherapy - analysis, design, models [PDF]
The deliberate use of viruses as oncolytic (cancer killing) agents has become evident since initial observations tracing back to the early 20th century. However, clinical use of therapeutic viruses requires them to be safe and effective.
Bhatt, Darshak; id_orcid, Bhatt, Darshak
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Enhancing oncolytic virotherapy: Observations from a Voronoi Cell-Based model
, 2020 Oncolytic virotherapy is a promising cancer treatment using genetically modified viruses. Unfortunately, virus particles rapidly decay inside the body, significantly hindering their efficacy.
Kim, PS +3 more
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Implications of MicroRNAs in Oncolytic Virotherapy [PDF]
Frontiers in Oncology, 2017 MicroRNAs (miRNAs) are an abundant class of small non-coding RNA molecules (~22 nt) that can repress gene expression. Deregulation of certain miRNAs is widely recognized as a robust biomarker for many neoplasms, as well as an important player in tumorigenesis and the establishment of tumoral microenvironments.
Xavier Bofill-De Ros +5 more
openaire +3 more sources
The combination therapy of oncolytic virotherapy. [PDF]
Front PharmacolIntroduction: Compared to other cancer immunotherapies, oncolytic viruses possess several advantages, including high killing efficiency, excellent targeting capabilities, minimal adverse reactions, and multiple pathways for tumor destruction. However, the efficacy of oncolytic viruses as a monotherapy often falls short of expectations.
Wang Y, Zhu M, Chi H, Liu Y, Yu G.
europepmc +4 more sources
Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy
Aggregate, Volume 7, Issue 6, June 2026.Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao +5 more
wiley +1 more source
Fractional time-delay mathematical modeling of oncolytic virotherapy [PDF]
, 2021 An emerging treatment tool which uses replication-competent viruses to dissipate cancers without causing deficit to normal tissues, named as oncolytic virotherapy, is discussed in the article.
Ertürk, Vedat Suat +3 more
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Nature CommunicationsOncolytic virotherapy holds promise for cancer treatment, but the factors determining its oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with cancer progression, yet their formation mechanism and role in oncolytic
Weiwei Dai +14 more
doaj +1 more source