Evaluation of CD46 re-targeted adenoviral vectors for clinical ovarian cancer intraperitoneal therapy [PDF]
, 2016 Ovarian cancer accounts for >140 000 deaths globally each year. Typically, disease is asymptomatic until an advanced, incurable stage. Although response to cytotoxic chemotherapy is frequently observed, resistance to conventional platinum-based therapies
A Hemminki +40 more
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Tumor Restrictions to Oncolytic Virus
Biomedicines, 2014 Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models.
Markus Vähä-Koskela, Ari Hinkkanen
doaj +1 more source
Oscillation thresholds via the novel MBR method with application to oncolytic virotherapy
Nonlinear Analysis, 2022 Oncolytic virotherapy is a therapy for the treatment of malignant tumours. In some undesirable cases, the injection of viral particles can lead to stationary oscillations, thus preventing the full destruction of the tumour mass.
Bruno Buonomo +2 more
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Cytolytic replication of echoviruses in colon cancer cell lines [PDF]
, 2011 Background Colorectal cancer is one of the most common cancers in the world, killing nearly 50% of patients afflicted. Though progress is being made within surgery and other complementary treatments, there is still need for new and more effective ...
Stina Israelsson +3 more
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Viruses, 2015 Oncolytic virotherapy for cancer is an innovative therapeutic option where the ability of a virus to promote cell lysis is harnessed and reprogrammed to selectively destroy cancer cells.
Janice Kim +3 more
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Adenovirus-Mediated Sensitization to the Cytotoxic Drugs Docetaxel and Mitoxantrone Is Dependent on Regulatory Domains in the E1ACR1 Gene-Region [PDF]
, 2012 Oncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies.
Daniel Öberg +7 more
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Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model [PDF]
, 2016 Background: Gene-based virotherapy mediated by oncolytic viruses is currently experiencing a renaissance in cancer therapy. However, relatively little attention has been given to the potentiality of dual gene virotherapy strategy as a novel therapeutic ...
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Frontiers in NeurologyHigh-grade gliomas (HGG) such as glioblastoma are the most aggressive primary malignancies of the central nervous system. The median overall survival of glioblastoma is <15 months despite treatment with surgery, radiotherapy, and chemotherapy ...
Zhihong Qian +4 more
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Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis
, 2018 Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that may be further combined with the existing therapeutic modalities to enhance their effects.
Eladdadi, Amina +4 more
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The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity [PDF]
, 2014 The oncolytic adenovirus Delta24-RGD represents a new promising therapeutic agent for patients with a malignant glioma and is currently under investigation in clinical phase I/II trials.
Debets, J.E.M.A. (Reno) +7 more
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