Results 91 to 100 of about 12,104 (196)

Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization.

PLoS Computational Biology, 2019
Oncolytic virotherapies, including the modified herpes simplex virus talimogene laherparepvec (T-VEC), have shown great promise as potent instigators of anti-tumour immune effects.
Tyler Cassidy, Morgan Craig
doaj   +1 more source

Oncolytic viruses as anticancer vaccines

Frontiers in Oncology, 2014
Oncolytic virotherapy has shown impressive results in preclinical studies and first promising therapeutic outcomes in clinical trials as well. Since viruses are known for a long time as excellent vaccination agents, oncolytic viruses are now designed as ...
Norman eWoller, Engin eGürlevik, Cristina-Ileana eUreche, Anja eSchumacher, Florian eKühnel   +4 more
doaj   +1 more source

Orthotopic hepatocellular carcinoma: molecular imaging-monitored intratumoral hyperthermia-enhanced direct oncolytic virotherapy

International Journal of Hyperthermia, 2019
Objective: To validate the feasibility of molecular imaging-monitored intratumoral radiofrequency hyperthermia (RFH) enhanced direct oncolytic virotherapy for hepatocellular carcinoma (HCC).
Jingjing Song, Feng Zhang, Jiansong Ji, Minjiang Chen, Qiang Li, Qiaoyou Weng, Shannon Gu, Matthew J. Kogut, Xiaoming Yang   +8 more
doaj   +1 more source

Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?

Viruses, 2015
The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal ...
Samantha Turnbull, Emma J. West, Karen J. Scott, Elizabeth Appleton, Alan Melcher, Christy Ralph   +5 more
doaj   +1 more source

Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy

Journal of Biomedical Science, 2019
Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies.
Mohsen Keshavarz, Farid Solaymani-Mohammadi, Seyed Mohammad Miri, Amir Ghaemi   +3 more
doaj   +1 more source

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells [PDF]

, 2013
Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular ...
Aki Yoshida, Aogi, Clayman, Emmrich, Futoshi Uno, Hiroshi Tazawa, Itoshima, Joe Hasei, Shuhei Osaki, Shunsuke Kagawa, Teppei Onishi, Ternovoi, Toshifumi Ozaki, Toshiyoshi Fujiwara, Toshiyuki Kunisada, Tsuyoshi Sasaki, Umehara, van Beusechem, Yasuaki Yamakawa, Yasuo Urata, Yuuri Hashimoto, Zeng   +21 more
core   +1 more source

Editorial: Oncolytic virotherapy

Frontiers in Molecular Biosciences, 2023
Ahmed Majeed Al-Shammari, Pier Paolo Piccaluga, Pier Paolo Piccaluga   +2 more
openaire   +3 more sources

Current perspectives of virotherapy as a cancer treatment strategy

Инфекция и иммунитет
Analysis of scientific literature presented in the main databases (PubMed, CyberLeninka, Google Scholar, Scopus) evidence that after cardiovascular diseases malignant tumors hold the second place among the most common causes of mortality in both ...
Lyubov D. Vlasova
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Enhanced susceptibility of cancer cells to oncolytic rhabdo-virotherapy by expression of Nodamura virus protein B2 as a suppressor of RNA interference

Journal for ImmunoTherapy of Cancer, 2018
Antiviral responses are barriers that must be overcome for efficacy of oncolytic virotherapy. In mammalian cells, antiviral responses involve the interferon pathway, a protein-signaling cascade that alerts the immune system and limits virus propagation ...
Donald Bastin, Amelia S. Aitken, Adrian Pelin, Larissa A. Pikor, Mathieu J. F. Crupi, Michael S. Huh, Marie-Claude Bourgeois-Daigneault, John C. Bell, Carolina S. Ilkow   +8 more
doaj   +1 more source

A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model

Molecular Therapy: Oncolytics, 2017
Oncolytic virotherapy is a treatment approach with increasing clinical relevance, as indicated by the marked survival benefit seen in animal models and its current exploration in human patients with cancer.
Julius W. Kim, Jason Miska, Jacob S. Young, Aida Rashidi, J. Robert Kane, Wojciech K. Panek, Deepak Kanojia, Yu Han, Irina V. Balyasnikova, Maciej S. Lesniak   +9 more
doaj   +1 more source