Results 91 to 100 of about 28,421 (276)

Combination therapy with reovirus and anti-PD-1 blockade controls tumor growth through innate and adaptive immune responses. [PDF]

, 2016
Oncolytic reovirus can be delivered both systemically and intratumorally, in both pre-clinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and anti-tumor activity is directly ...
Coffey, M, Diaz, RM, Harrington, K, Ilett, E, Kottke, T, Melcher, A, Pandha, H, Parrish, C, Rajani, K, Shim, KG, Thompson, J, Vile, R, Zaidi, S   +12 more
core   +1 more source

Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Nature Communications
The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatment failures ...
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, A. H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, D. van der Horst, Christoph F Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna S. Twayana, Rasmus N Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E Kiib, Florian E H Kromm, Hauke J. Weiss, Daniele Di Carlo, M. Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, T. Tong, A. Ozsvar, W. Hou, Vivien R. Schack, C. K. Holm, Yunan Zheng, Melanie Ruzek, Joanna M Kalucka, L. de la Vega, W. Elgaher, A. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, L. O'Neill, D. Roy, Markus M. Rinschen, Nadine van Montfoort, J. Diallo, H. Farin, Tommy Alain, D. Olagnier   +49 more
semanticscholar   +1 more source

Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs [PDF]

, 2017
BACKGROUND: Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation.
Arafat WO, Arafat WO, Datta R, Deb P, Fiveash JB, Hsu H, Kanzawa T, Kawakami Y, Kufe D, Nandi S, Nenoi M, Nieder C, Pinsker M, Rosenfeld ME, Sonabend AM, Tsai‐Morris CH, Weichselbaum RR   +16 more
core   +2 more sources

Combination of Oncolytic Virotherapy with Different Antitumor Approaches against Glioblastoma

International Journal of Molecular Sciences
Glioblastoma is one of the most malignant and aggressive tumors of the central nervous system. Despite the standard therapy consisting of maximal surgical resection and chemo- and radiotherapy, the median survival of patients with this diagnosis is about
A. Ageenko, N. Vasileva, Vladimir Richter, E. Kuligina   +3 more
semanticscholar   +1 more source

Glioblastoma microenvironment and its reprogramming by oncolytic virotherapy

Frontiers in Cellular Neuroscience, 2022
Glioblastoma (GBM), a highly aggressive form of brain tumor, responds poorly to current conventional therapies, including surgery, radiation therapy, and systemic chemotherapy.
Zhongbing Qi, X. Long, Jiyan Liu, Pi-Yun Cheng   +3 more
semanticscholar   +1 more source

Principles and Practice Guidelines of Microbiota Medicine: Statements From the CHINAGUT Conference

Microbiota Medicine Research, EarlyView.
The 2025 CHINAGUT Conference convened a panel of 48 clinicians from 39 hospitals in 5 countries to develop 15 key statements, aimed at providing clinicians, educators, and healthcare administrators with a comprehensive framework to advance education, clinical practice, research, and public popularization in microbiota medicine.
Faming Zhang, Zheshun Pi, Sunny Hei Wong, Vineet Ahuja, Serena Porcari, Dai Ishikawa, Hailong Cao, Linlin Chen, Ning Chen, Xiong Chen, Bota Cui, Xiao Ding, Xingxiang He, Jia Hu, Jiang Jin, Ji Li, Weiwei Liao, Jingmei Liu, Ling Liu, Yanyan Liu, Yaping Liu, Yu Liu, Chen Lu, Gaochen Lu, Muhan Lv, Xiangjun Meng, Yongzhan Nie, Qian Ren, Lixuan Sang, Xin Sun, Yang Sun, Hongliang Tian, Baohong Wang, Honggang Wang, Liangjing Wang, Xin Wang, Weihong Wang, Zheyu Wang, Yanling Wei, Quan Wen, Lihao Wu, Xia Wu, Lijing Xiong, Guoliang Ye, Bo Yi, You Yu, Yue Zeng, Huihong Zhai, Ting Zhang, Zulun Zhang, Li Zhou, Li Zhu, Kaichun Wu   +52 more
wiley   +1 more source

A genetically modified adenoviral vector with a phage display-derived peptide incorporated into fiber fibritin chimera prolongs survival in experimental glioma [PDF]

, 2015
The dismal clinical context of advanced-grade glioma demands the development of novel therapeutic strategies with direct patient impact. Adenovirus-mediated virotherapy represents a potentially effective approach for glioma therapy.
Ahmed, Atique U, Balyasnikova, Irina V, Chang, Alan L, Curiel, David T, Han, Yu, Kane, J. Robert, Kanojia, Deepak, Kim, Julius W, Lesniak, Maciej S, Miska, Jason, Morshed, Ramin A, Young, Jacob S, Zhang, Lingjiao   +12 more
core   +2 more sources

The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient

Cancer Gene Therapy
Colorectal cancer (CRC) is known to be resistant to immunotherapy. In our phase-I clinical trial, one patient achieved a 313-day prolonged response during the combined treatment of oncolytic virotherapy and immunotherapy.
Hangyu Zhang, Yiqing Ren, Feiyu Wang, Xiaoxuan Tu, Z. Tong, Lulu Liu, Yi Zheng, Peng Zhao, Jinlin Cheng, Jianwen Li, Weijia Fang, Xia Liu   +11 more
semanticscholar   +1 more source

A Three-Dimensional Organoid Model of Primary Breast Cancer to Investigate the Effects of Oncolytic Virotherapy

Frontiers in Molecular Biosciences, 2022
Background: Although several oncolytic viruses have already been tested in early-stage clinical studies of breast cancer, there is still an urgent need to develop patient-derived experimental systems that mimic the response of breast cancer to oncolytic ...
M. E. Carter, A. Hartkopf, Anna-Margaretha Wagner, L. Volmer, S. Brucker, S. Berchtold, U. Lauer, A. Koch   +7 more
semanticscholar   +1 more source

Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Shriya Makam, Hana M. Dobrovolny
wiley   +1 more source