Results 31 to 40 of about 7,402 (232)
Pathogens, 2023 Brain tumor incidence is on the rise, and glioblastoma comprises the majority of primary tumors. Despite maximal safe resection and adjuvant chemoradiation, median survival for high-grade glioma remains poor.
Sauson Soldozy +10 more
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Personalizing Oncolytic Virotherapy?
Molecular Therapy, 2007 raditionally, cancer therapies have been based on the empiric discovery of drugs and/or biological agents that act selectively against tumor cells. Recently, however, a generation of rationally discov-ered drugs and agents has been developed that shows encouraging benefi t in treating cancers.
E. Antonio Chiocca, Balveen Kaur
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Current strategies in engaging oncolytic viruses with antitumor immunity
Molecular Therapy: Oncolytics, 2021 Oncolytic virotherapy has produced promising yet limited results in preclinical and clinical studies. Besides direct oncolytic activity, a significant therapeutic mechanism of oncolytic virotherapy is the induction of tumor-specific immunity ...
Drew Ashton Boagni +2 more
doaj
Oncolytic Virotherapy for Hematological Malignancies [PDF]
Advances in Virology, 2012 Hematological malignancies such as leukemias, lymphomas, multiple myeloma (MM), and the myelodysplastic syndromes (MDSs) primarily affect adults and are difficult to treat. For high-risk disease, hematopoietic stem cell transplant (HCT) can be used. However, in the setting of autologous HCT, relapse due to contamination of the autograft with cancer ...
Swarna Bais +4 more
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Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy
Molecular Cancer, 2020 As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for conditional-replication within carcinoma cells leading to cell death via
Bin Zhang, Ping Cheng
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Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages
Journal of Translational Medicine, 2023 Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host immune response are irreplaceable advantages of cancer immunotherapy.
Zhen Shen +7 more
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Oncolytic virotherapy for pancreatic cancer [PDF]
Expert Reviews in Molecular Medicine, 2011 Within the past decade, many oncolytic viruses (OVs) have been studied as potential treatments for pancreatic cancer and some of these are currently under clinical trials. The applicability of certain OVs, such as adenoviruses, herpesviruses and reoviruses, for the treatment of pancreatic cancer has been intensively studied for several years, whereas ...
Grant McFadden +2 more
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Mesenchymal stem cells as carrier cells to enable effective intratumoral delivery of oncolytic virus for oncolytic virotherapy: a systematic review [PDF]
arXiv, 2022 Oncolytic viruses, which may be naturally occurring or genetically engineered, are a type of virus that infects and destroy cancer cells preferentially. Owing to their selectivity, they outperform conventional chemotherapy and radiotherapy, which both have a tendency to impact non-target cells and cause unwanted adverse side effects.
arxiv
Oncolytic Virotherapy: From Bench to Bedside [PDF]
Frontiers in Cell and Developmental Biology, 2021 Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years. They mainly function by direct oncolysis, inducing an anticancer immune response and expressing exogenous effector ...
Ludi Yang +9 more
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Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols [PDF]
Bulletin of Mathematical Biology 80: 1615-1629 (2018), 2019 Oncolytic virotherapy is an experimental cancer treatment that uses genetically engineered viruses to target and kill cancer cells. One major limitation of this treatment is that virus particles are rapidly cleared by the immune system, preventing them from arriving at the tumour site.
arxiv +1 more source